Literature DB >> 30938983

Extradomain-B Fibronectin-Targeted Dextran-Based Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Probe for Detecting Pancreatic Cancer.

Zheng Han1,2, Shuixing Zhang1,3, Kenji Fujiwara4, Jia Zhang1, Yuguo Li1,2, Jing Liu1,5, Peter C M van Zijl1,2, Zheng-Rong Lu6, Lei Zheng4, Guanshu Liu1,2.   

Abstract

A dextran-peptide conjugate was developed for magnetic resonance (MR) molecular imaging of pancreatic ductal adenocarcinoma (PDAC) through its overexpressed microenvironment biomarker, extradomain-B fibronectin (EDB-FN). This new agent consists of diamagnetic and biocompatible dextran and a targeting peptide. Dextrans can be directly detected by chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) without the need for radionuclide or metallic labeling. In addition, large molecular weight dextran, dextran 10 (MW ∼ 10 kDa), provides an approximately 50 times higher sensitivity per molecule than a single glucose unit. The potential of this highly biocompatible diamagnetic probe is demonstrated in a murine syngeneic allograft PDAC tumor model. The biocompatibility and sensitivity of this new agent clearly show potential for a path to clinical translation.

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Year:  2019        PMID： 30938983      PMCID： PMC6896991          DOI： 10.1021/acs.bioconjchem.9b00161

Source DB:  PubMed          Journal:  Bioconjug Chem        ISSN： 1043-1802            Impact factor:   4.774


  50 in total

1.  Imaging the DNA Alkylator Melphalan by CEST MRI: An Advanced Approach to Theranostics.

Authors:  Ethel J Ngen; Amnon Bar-Shir; Anna Jablonska; Guanshu Liu; Xiaolei Song; Roxana Ansari; Jeff W M Bulte; Miroslaw Janowski; Monica Pearl; Piotr Walczak; Assaf A Gilad
Journal:  Mol Pharm       Date:  2016-07-26       Impact factor: 4.939

Review 2.  Rational chemical design of the next generation of molecular imaging probes based on physics and biology: mixing modalities, colors and signals.

Authors:  Hisataka Kobayashi; Michelle R Longmire; Mikako Ogawa; Peter L Choyke
Journal:  Chem Soc Rev       Date:  2011-05-23       Impact factor: 54.564

3.  In vivo multicolor molecular MR imaging using diamagnetic chemical exchange saturation transfer liposomes.

Authors:  Guanshu Liu; Matthew Moake; Yah-el Har-el; Chris M Long; Kannie W Y Chan; Amanda Cardona; Muksit Jamil; Piotr Walczak; Assaf A Gilad; George Sgouros; Peter C M van Zijl; Jeff W M Bulte; Michael T McMahon
Journal:  Magn Reson Med       Date:  2011-08-23       Impact factor: 4.668

4.  Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers.

Authors:  Matthew R Dreher; Wenge Liu; Charles R Michelich; Mark W Dewhirst; Fan Yuan; Ashutosh Chilkoti
Journal:  J Natl Cancer Inst       Date:  2006-03-01       Impact factor: 13.506

5.  Dextran-peptide hybrid for efficient gene delivery.

Authors:  Qiong Tang; Bin Cao; Xia Lei; Bingbing Sun; Yanqiao Zhang; Gang Cheng
Journal:  Langmuir       Date:  2014-05-01       Impact factor: 3.882

6.  The targeted immunocytokine L19-IL2 efficiently inhibits the growth of orthotopic pancreatic cancer.

Authors:  Karola Wagner; Petra Schulz; Arne Scholz; Bertram Wiedenmann; Andreas Menrad
Journal:  Clin Cancer Res       Date:  2008-08-01       Impact factor: 12.531

7.  MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST).

Authors:  Peter C M van Zijl; Craig K Jones; Jimin Ren; Craig R Malloy; A Dean Sherry
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-05       Impact factor: 11.205

8.  Acidic extracellular microenvironment and cancer.

Authors:  Yasumasa Kato; Shigeyuki Ozawa; Chihiro Miyamoto; Yojiro Maehata; Atsuko Suzuki; Toyonobu Maeda; Yuh Baba
Journal:  Cancer Cell Int       Date:  2013-09-03       Impact factor: 5.722

9.  MRI of breast tumor initiating cells using the extra domain-B of fibronectin targeting nanoparticles.

Authors:  Yujin Sun; Hoe Suk Kim; Jinho Park; Mulan Li; Lianji Tian; YoonSeok Choi; Byung Ihn Choi; Sangyong Jon; Woo Kyung Moon
Journal:  Theranostics       Date:  2014-06-10       Impact factor: 11.556

Review 10.  Systemic Chemotherapy in Advanced Pancreatic Cancer.

Authors:  Hee Seung Lee; Seung Woo Park
Journal:  Gut Liver       Date:  2016-05-23       Impact factor: 4.519
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  8 in total

Review 1.  Theranostic small interfering RNA nanoparticles in cancer precision nanomedicine.

Authors:  Zhihang Chen; Balaji Krishnamachary; Jesus Pachecho-Torres; Marie-France Penet; Zaver M Bhujwalla
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2019-10-23

2.  Dynamic contrast-enhanced CEST MRI using a low molecular weight dextran.

Authors:  Zheng Han; Chuheng Chen; Xiang Xu; Renyuan Bai; Verena Staedtke; Jianpan Huang; Kannie W Y Chan; Jiadi Xu; David O Kamson; Zhibo Wen; Linda Knutsson; Peter C M van Zijl; Guanshu Liu
Journal:  NMR Biomed       Date:  2021-11-15       Impact factor: 4.044

Review 3.  Repurposing Clinical Agents for Chemical Exchange Saturation Transfer Magnetic Resonance Imaging: Current Status and Future Perspectives.

Authors:  Zelong Chen; Zheng Han; Guanshu Liu
Journal:  Pharmaceuticals (Basel)       Date:  2020-12-24

Review 4.  A Brief History and Future Prospects of CEST MRI in Clinical Non-Brain Tumor Imaging.

Authors:  Tianxin Gao; Chuyue Zou; Yifan Li; Zhenqi Jiang; Xiaoying Tang; Xiaolei Song
Journal:  Int J Mol Sci       Date:  2021-10-26       Impact factor: 5.923

Review 5.  Immune Cell Modulation of the Extracellular Matrix Contributes to the Pathogenesis of Pancreatic Cancer.

Authors:  Ramiz S Ahmad; Timothy D Eubank; Slawomir Lukomski; Brian A Boone
Journal:  Biomolecules       Date:  2021-06-17

6.  Overexpression of Extradomain-B Fibronectin is Associated with Invasion of Breast Cancer Cells.

Authors:  Amita Vaidya; Helen Wang; Victoria Qian; Hannah Gilmore; Zheng-Rong Lu
Journal:  Cells       Date:  2020-08-03       Impact factor: 6.600

7.  Magnetic Resonance Molecular Imaging of Extradomain B Fibronectin Improves Imaging of Pancreatic Cancer Tumor Xenografts.

Authors:  Peter Qiao; Nadia R Ayat; Amita Vaidya; Songqi Gao; Wenyu Sun; Samuel Chou; Zheng Han; Hannah Gilmore; Jordan M Winter; Zheng-Rong Lu
Journal:  Front Oncol       Date:  2020-10-30       Impact factor: 6.244

8.  Noninvasive assessment and therapeutic monitoring of drug-resistant colorectal cancer by MR molecular imaging of extradomain-B fibronectin.

Authors:  Amita Vaidya; Nadia Ayat; Megan Buford; Helen Wang; Aman Shankardass; Yiqing Zhao; Hannah Gilmore; Zhenghe Wang; Zheng-Rong Lu
Journal:  Theranostics       Date:  2020-09-08       Impact factor: 11.556
  8 in total

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