Iain B McInnes1,2, Lluís Puig3,4, Alice B Gottlieb3,4, Christopher T Ritchlin3,4, Michael Song3,4, Yin You3,4, Shelly Kafka3,4, G James Morgan3,4, Proton Rahman3,4, Arthur Kavanaugh. 1. From the University of Glasgow, Institute of Infection Immunity and Inflammation, Glasgow Biomedical Research Centre, Glasgow, Scotland; Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York; University of Rochester, Medical Center, Rochester, New York; Janssen Research & Development LLC, Spring House, Pennsylvania; Janssen Scientific Affairs LLC, Horsham, Pennsylvania, USA; Memorial University, St. John's, Newfoundland and Labrador, Canada; University of California-San Diego, San Diego, California, USA. Iain.McInnes@glasgow.ac.uk. 2. I.B. McInnes, MD, PhD, University of Glasgow, Institute of Infection Immunity and Inflammation, Glasgow Biomedical Research Centre; L. Puig, MD, PhD, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona; A.B. Gottlieb, MD, PhD, Department of Dermatology, Icahn School of Medicine at Mount Sinai; C.T. Ritchlin, MD, MPH, University of Rochester, Medical Center; M. Song, MD, Janssen Research & Development LLC; Y. You, MS, Janssen Research & Development LLC; S. Kafka, MD, Janssen Scientific Affairs LLC; G.J. Morgan, MD, Janssen Scientific Affairs LLC; P. Rahman, MD, Memorial University; A. Kavanaugh, MD, University of California-San Diego. Iain.McInnes@glasgow.ac.uk. 3. From the University of Glasgow, Institute of Infection Immunity and Inflammation, Glasgow Biomedical Research Centre, Glasgow, Scotland; Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York; University of Rochester, Medical Center, Rochester, New York; Janssen Research & Development LLC, Spring House, Pennsylvania; Janssen Scientific Affairs LLC, Horsham, Pennsylvania, USA; Memorial University, St. John's, Newfoundland and Labrador, Canada; University of California-San Diego, San Diego, California, USA. 4. I.B. McInnes, MD, PhD, University of Glasgow, Institute of Infection Immunity and Inflammation, Glasgow Biomedical Research Centre; L. Puig, MD, PhD, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona; A.B. Gottlieb, MD, PhD, Department of Dermatology, Icahn School of Medicine at Mount Sinai; C.T. Ritchlin, MD, MPH, University of Rochester, Medical Center; M. Song, MD, Janssen Research & Development LLC; Y. You, MS, Janssen Research & Development LLC; S. Kafka, MD, Janssen Scientific Affairs LLC; G.J. Morgan, MD, Janssen Scientific Affairs LLC; P. Rahman, MD, Memorial University; A. Kavanaugh, MD, University of California-San Diego.
Abstract
OBJECTIVE:Evaluate enthesitis, physical function, and health-related quality of life (HRQOL) among patients with psoriatic arthritis (PsA) who are naive to anti-tumor necrosis factor agents. METHODS: In PSUMMIT 1 and 2, patients with PsA were randomized to placebo or ustekinumab 45 mg or 90 mg. Enthesitis was assessed at weeks 0 and 24 (Maastricht Ankylosing Spondylitis Enthesitis Score). Assessments included Health Assessment Questionnaire-Disability Index (HAQ-DI), Medical Outcomes Study Short Form-36 (SF-36) physical component summary/mental component summary (PCS/MCS), and American College of Rheumatology 20 (ACR20). RESULTS: At Week 24, 21 had worsened enthesitis, 158 had improved enthesitis, and 412 had unchanged enthesitis. Improved enthesitis was associated with improvements in HAQ-DI and SF-36 MCS. Results were similar for ACR20 responders and nonresponders. CONCLUSION: Improvement in enthesitis at Week 24 was associated with improvements in physical function/HRQOL regardless of ACR20 response.
RCT Entities:
OBJECTIVE: Evaluate enthesitis, physical function, and health-related quality of life (HRQOL) among patients with psoriatic arthritis (PsA) who are naive to anti-tumornecrosis factor agents. METHODS: In PSUMMIT 1 and 2, patients with PsA were randomized to placebo or ustekinumab 45 mg or 90 mg. Enthesitis was assessed at weeks 0 and 24 (Maastricht Ankylosing Spondylitis Enthesitis Score). Assessments included Health Assessment Questionnaire-Disability Index (HAQ-DI), Medical Outcomes Study Short Form-36 (SF-36) physical component summary/mental component summary (PCS/MCS), and American College of Rheumatology 20 (ACR20). RESULTS: At Week 24, 21 had worsened enthesitis, 158 had improved enthesitis, and 412 had unchanged enthesitis. Improved enthesitis was associated with improvements in HAQ-DI and SF-36 MCS. Results were similar for ACR20 responders and nonresponders. CONCLUSION: Improvement in enthesitis at Week 24 was associated with improvements in physical function/HRQOL regardless of ACR20 response.
Entities:
Keywords:
ENTHESITIS; HEALTH-RELATED QUALITY OF LIFE; PSORIATIC ARTHRITIS; USTEKINUMAB
Authors: Iain B McInnes; Soumya D Chakravarty; Isabel Apaolaza; Shelly Kafka; Elizabeth C Hsia; Yin You; Arthur Kavanaugh Journal: RMD Open Date: 2019-08-18