Literature DB >> 3093317

Effect of enprostil, a synthetic prostaglandin E2 on 24 hour intragastric acidity, nocturnal acid and pepsin secretion.

M Deakin, J Ramage, A Paul, S P Gray, J Billings, J G Williams.   

Abstract

We have studied the effect of a prostaglandin E2 analogue (enprostil), on intragastric acidity, gastric acid and pepsin outputs during a 24 hour period in nine patients with duodenal ulcer in remission. Enprostil 35 micrograms bd dose inhibited 24 hour intragastric acidity by 38% and a 70 micrograms nocturnal dose by 33%. Decrease in nocturnal pepsin secretion was both volume and concentration related.

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Year:  1986        PMID： 3093317      PMCID： PMC1433785          DOI： 10.1136/gut.27.9.1054

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  12 in total

1.  The effect of secretin, glucagon, and duodenal acidification on pepsin secretion in man.

Authors:  A M Brooks; J Isenberg; M I Grossman
Journal:  Gastroenterology       Date:  1969-08       Impact factor: 22.682

2.  Smoking, gastric secretion, and inhibition by H2 receptor antagonists.

Authors:  M Deakin; J Ramage; S P Gray; J Billings; D Colin-Jones; J G Williams
Journal:  Lancet       Date:  1985-05-04       Impact factor: 79.321

3.  Single nocturnal dose of an H2 receptor antagonist for the treatment of duodenal ulcer.

Authors:  T Gledhill; O M Howard; M Buck; A Paul; R H Hunt
Journal:  Gut       Date:  1983-10       Impact factor: 23.059

4.  pH stability and activity curves of pepsin with special reference to their clinical importance.

Authors:  D W Piper; B H Fenton
Journal:  Gut       Date:  1965-10       Impact factor: 23.059

5.  24-hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer during oral administration of cimetidine and atropine.

Authors:  R E Pounder; R H Hunt; S H Vincent; G J Milton-Thompson; J J Misiewicz
Journal:  Gut       Date:  1977-02       Impact factor: 23.059

6.  Ranitidine 150 mg twice daily vs 300 mg nightly in treatment of duodenal ulcers.

Authors:  A Ireland; D G Colin-Jones; P Gear; P L Golding; J K Ramage; J G Williams; R J Leicester; C L Smith; G Ross; J Bamforth
Journal:  Lancet       Date:  1984-08-04       Impact factor: 79.321

7.  Gastric bicarbonate secretion in humans. Effect of pentagastrin, bethanechol, and 11,16,16-trimethyl prostaglandin E2.

Authors:  M Feldman
Journal:  J Clin Invest       Date:  1983-07       Impact factor: 14.808

8.  Cobalamin-specific R binder in pernicious anemia gastric juice: production by digestive enzyme action on saliva R binder.

Authors:  B C Herzlich; V Herbert
Journal:  Am J Gastroenterol       Date:  1985-11       Impact factor: 10.864

9.  Kinetic assay of human pepsin with albumin-bromphenol blue as substrate.

Authors:  S P Gray; J A Billings
Journal:  Clin Chem       Date:  1983-03       Impact factor: 8.327

10.  The effects of impromidine and pentagastrin on gastric output of histamine, acid and pepsin in man.

Authors:  N R Peden; E J Boyd; H Callachan; D M Shepherd; K G Wormsley
Journal:  Hepatogastroenterology       Date:  1982-02
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  1 in total

Review 1.  Enprostil. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of peptic ulcer disease.

Authors:  K L Goa; J P Monk
Journal:  Drugs       Date:  1987-11       Impact factor: 9.546
  1 in total

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