| Literature DB >> 6146821 |
A Ireland, D G Colin-Jones, P Gear, P L Golding, J K Ramage, J G Williams, R J Leicester, C L Smith, G Ross, J Bamforth.
Abstract
102 patients with endoscopically proven duodenal ulcers were randomly allocated to treatment with ranitidine either 150 mg twice a day or 300 mg every evening for 4 weeks in a prospective double-blind study. The two groups were similar. 48/57 (84%) healed on ranitidine 150 mg twice daily and 43/45 (96%) healed on 300 mg every evening (p = 0.9)--that is, ranitidine 300 mg as a single night time dose is as effective as 150 mg twice daily. The results also indicate the importance of overnight gastric acidity in the pathogenesis of duodenal ulcers.Entities:
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Year: 1984 PMID： 6146821 DOI： 10.1016/s0140-6736(84)90312-x
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321