Gregg T Kokame1,2,3,4,5, Nicolas A Yannuzzi6, Jessica G Shantha2,3,4,7, Maya Yamane8, Nidhi Relhan6, Jeffrey Gross9, Edwin H Ryan10, Harry W Flynn6. 1. Division of Ophthalmology, Department of Surgery, University of Hawaii School of Medicine, Honolulu, Hawaii. 2. The Retina Center at Pali Momi, Aiea, Hawaii. 3. Retina Consultants of Hawaii, Aiea, Hawaii. 4. Hawaii Macula and Retina Institute, Aiea, Hawaii. 5. John A. Burns School of Medicine, University of Hawaii School of Medicine, Honolulu, Hawaii. 6. Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. 7. Department of Ophthalmology, University of California San Francisco, Francis I. Proctor Foundation, San Francisco, California. 8. Columbia University College of Physicians and Surgeons, New York, New York. 9. Carolina Retina Center, Columbia, South Carolina; and. 10. VitreoRetinal Surgery, Minneapolis, Minnesota.
Abstract
PURPOSE: To report patients who demonstrated an alteration in the clinical and optical coherence tomography features of neovascular age-related macular degeneration after resolution of endophthalmitis. METHODS: Retrospective case series of the subsequent changes in the macula and need for anti-vascular endothelial growth factor therapy in patients with neovascular age-related macular degeneration who developed endophthalmitis after intravitreal injection. RESULTS: The study included seven eyes of seven patients with follow-up ranging between 3 months and 11 years. The vitreous cultures (n = 7) before intravitreal antibiotic injection were the following: culture-negative (4) and coagulase-negative Staphylococcus (3). Initial treatment included vitreous tap and injection (4) and pars plana vitrectomy (3). In 5/7 eyes, the optical coherence tomography showed resolution of subretinal fluid and serous pigment epithelial detachment, and there was no additional anti-vascular endothelial growth factor treatment administered. CONCLUSION: After successful treatment of endophthalmitis in patients with neovascular age-related macular degeneration, there was relative involution of the maculopathy and reduced anti-vascular endothelial growth factor treatment burden in this series.
PURPOSE: To report patients who demonstrated an alteration in the clinical and optical coherence tomography features of neovascular age-related macular degeneration after resolution of endophthalmitis. METHODS: Retrospective case series of the subsequent changes in the macula and need for anti-vascular endothelial growth factor therapy in patients with neovascular age-related macular degeneration who developed endophthalmitis after intravitreal injection. RESULTS: The study included seven eyes of seven patients with follow-up ranging between 3 months and 11 years. The vitreous cultures (n = 7) before intravitreal antibiotic injection were the following: culture-negative (4) and coagulase-negative Staphylococcus (3). Initial treatment included vitreous tap and injection (4) and pars plana vitrectomy (3). In 5/7 eyes, the optical coherence tomography showed resolution of subretinal fluid and serous pigment epithelial detachment, and there was no additional anti-vascular endothelial growth factor treatment administered. CONCLUSION: After successful treatment of endophthalmitis in patients with neovascular age-related macular degeneration, there was relative involution of the maculopathy and reduced anti-vascular endothelial growth factor treatment burden in this series.
Authors: Andrew A Moshfeghi; Philip J Rosenfeld; Harry W Flynn; Stephen G Schwartz; Janet L Davis; Timothy G Murray; William E Smiddy; Audina M Berrocal; Sander R Dubovy; Wen-Hsiang Lee; Thomas A Albini; Geeta A Lalwani; Jaclyn L Kovach; Carmen A Puliafito Journal: Retina Date: 2011-04 Impact factor: 4.256
Authors: Ninel Z Gregori; Harry W Flynn; Stephen G Schwartz; Philip J Rosenfeld; Kamyar Vaziri; Andrew A Moshfeghi; Jorge A Fortun; Jaclyn L Kovach; Sander R Dubovy; Thomas A Albini; Janet L Davis; Audina M Berrocal; William E Smiddy Journal: Ophthalmic Surg Lasers Imaging Retina Date: 2015-06 Impact factor: 1.300
Authors: Daniel F Martin; Maureen G Maguire; Gui-shuang Ying; Juan E Grunwald; Stuart L Fine; Glenn J Jaffe Journal: N Engl J Med Date: 2011-04-28 Impact factor: 91.245
Authors: Steven J Yoon; David Y Rhee; Jeffrey L Marx; Gregory R Blaha; Adam H Rogers; Caroline R Baumal; Elias Reichel; Jay S Duker Journal: Am J Ophthalmol Date: 2009-03-09 Impact factor: 5.258
Authors: Matthias Hammon; Martin Herrmann; Oliver Bleiziffer; Galyna Pryymachuk; Laura Andreoli; Luis E Munoz; Kerstin U Amann; Michele Mondini; Marisa Gariglio; Paolo Airó; Vera S Schellerer; Antonis K Hatzopoulos; Raymund E Horch; Ulrich Kneser; Michael Stürzl; Elisabeth Naschberger Journal: J Cell Mol Med Date: 2011-07 Impact factor: 5.310