PURPOSE: To evaluate the effects on visual function and choroidal neovascularization (CNV) progression in a case of subretinal CNV due to Candida endophthalmitis treated with a combination of photodynamic therapy (PDT) and drugs. METHODS: A 28-year-old one-eyed woman with CNV in the right eye came to our observation. The CNV developed as a consequence of Candida endophthalmitis. The CNV was treated with six PDT treatments with verteporfin in association with systemic steroid therapy with prednisone (100 mg/day to reduce) and fluconazole (800 mg/day to reduce). Visual acuity (VA) was assessed in pre-PDT conditions and after six PDT treatments (24 months of follow-up). RESULTS: Pre-PDT VA was 20/125; after 24 months of follow-up, six PDT re-treatments, and pharmacologic therapy, VA was stabilized at 20/100. CONCLUSIONS: In our case, associated PDT and drug therapies were safe and useful to maintain VA and to arrest CNV progression in the foveal region after 2 years of follow-up.
PURPOSE: To evaluate the effects on visual function and choroidal neovascularization (CNV) progression in a case of subretinal CNV due to Candida endophthalmitis treated with a combination of photodynamic therapy (PDT) and drugs. METHODS: A 28-year-old one-eyed woman with CNV in the right eye came to our observation. The CNV developed as a consequence of Candida endophthalmitis. The CNV was treated with six PDT treatments with verteporfin in association with systemic steroid therapy with prednisone (100 mg/day to reduce) and fluconazole (800 mg/day to reduce). Visual acuity (VA) was assessed in pre-PDT conditions and after six PDT treatments (24 months of follow-up). RESULTS: Pre-PDT VA was 20/125; after 24 months of follow-up, six PDT re-treatments, and pharmacologic therapy, VA was stabilized at 20/100. CONCLUSIONS: In our case, associated PDT and drug therapies were safe and useful to maintain VA and to arrest CNV progression in the foveal region after 2 years of follow-up.
Authors: Georgios Makragiannis; Kaveh Vahdani; Ester Carreño; Richard W J Lee; Andrew D Dick; Adam H Ross Journal: Int Ophthalmol Date: 2017-03-30 Impact factor: 2.031
Authors: Tianhong Dai; Beth B Fuchs; Jeffrey J Coleman; Renato A Prates; Christos Astrakas; Tyler G St Denis; Martha S Ribeiro; Eleftherios Mylonakis; Michael R Hamblin; George P Tegos Journal: Front Microbiol Date: 2012-04-10 Impact factor: 5.640
Authors: Gregg T Kokame; Nicolas A Yannuzzi; Jessica G Shantha; Maya Yamane; Nidhi Relhan; Jeffrey Gross; Edwin H Ryan; Harry W Flynn Journal: Retin Cases Brief Rep Date: 2021-09-01