Free-Breathing & Ungated Cardiac MRI Using Iterative SToRM (i-SToRM).

We introduce a local manifold regularization approach to recover dynamic MRI data from highly undersampled measurements. The proposed scheme relies on the manifold structure of local image patches at the same spatial location in a free-breathing cardiac MRI dataset; this approach is a generalization of the SmooThness Regularization on Manifolds (SToRM) scheme that exploits the global manifold structure of images in the dataset. Since the manifold structure of the patches varies depending on the spatial location and is often considerably simpler than the global one, this approach significantly reduces the data demand, facilitating the recovery from shorter scans. Since the navigator-based estimation of manifold structure pursued in SToRM is not feasible in this setting, a reformulation of SToRM is introduced. Specifically, the regularization term of the cost function involves the sum of robust distances between images sub-patches in the dataset. The optimization algorithm alternates between updating the images and estimating the manifold structure of the image patches. The utility of the proposed scheme is demonstrated in the context of in-vivo prospective free-breathing cardiac CINE MRI imaging with multichannel acquisitions and simulated phantoms. The new framework facilitates a reduction in scan time, as compared to the SToRM strategy.