| Literature DB >> 30928277 |
Eric Wei Chiang Chan1, Chu Yong Soon2, Joash Ban Lee Tan3, Siu Kuin Wong3, Yew Woh Hui4.
Abstract
Ursolic acid (UA) is a pentacyclic triterpene of the ursane type. As a common chemical constituent among species of the family Lamiaceae, UA possesses a broad spectrum of pharmacological properties. This overview focuses on the anticancer properties of UA against breast cancer (BC) and colorectal cancer (CRC) that are most common among women and men, respectively. In vitro studies have shown that UA inhibited the growth of BC and CRC cell lines through various molecular targets and signaling pathways. There are several in vivo studies on the cytotoxic activity of UA against BC and CRC. UA also inhibits the growth of other types of cancer. Studies on structural modifications of UA have shown that the -OH groups at C3 and at C28 are critical factors influencing the cytotoxic activity of UA and its derivatives. Some needs for future research are suggested. Sources of information were from ScienceDirect, Google Scholar and PubMed.Entities:
Keywords: Cytotoxic; Molecular targets; Signaling pathways; Ursolic acid
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Year: 2019 PMID： 30928277 DOI： 10.1016/j.joim.2019.03.003
Source DB: PubMed Journal: J Integr Med