Pei-Chun Fan1, Jason Chih-Hsiang Chang1, Chia-Ni Lin2, Cheng-Chia Lee1, Yi-Ting Chen3, Pao-Hsien Chu4, George Kou5, Yueh-An Lu5, Chih-Wei Yang5, Yung-Chang Chen6. 1. Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Medical Center, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan. 2. Graduate Institute, Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan. 3. Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Medical Center, Taiwan; Department of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan. 4. Department of Cardiology, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan. 5. Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Medical Center, Taiwan. 6. Division of Nephrology, Department of Medicine, Keelung Chang Gung Memorial Hospital, Taiwan. Electronic address: cyc2356@adm.cgmh.org.tw.
Abstract
BACKGROUND/ PURPOSE: Indoxyl sulfate (IS) is a protein-binding molecule that exhibits cardiovascular (CV) toxicity. This study determined whether the serum IS level can be used to predict the risk of major adverse CV events (MACEs) in patients with chronic kidney disease (CKD). METHODS: We studied 147 patients with CKD stage 1-5 over a 3-year follow-up period. IS was measured through mass spectrometry. Patients' demographics were collected and analyzed to predict outcomes by using multivariable Cox regression. RESULTS: Forty-seven (32.0%) patients had MACEs. IS remained significantly associated with MACEs after multivariable regression analysis. The area under the receiver operating characteristic curve for IS levels was 0.708 (95% confidence interval: 0.618-0.798). CONCLUSION: IS may have a critical role in the prediction of CV disease in patients with CKD. Further large-scale investigations are warranted and suggested.
BACKGROUND/ PURPOSE:Indoxyl sulfate (IS) is a protein-binding molecule that exhibits cardiovascular (CV) toxicity. This study determined whether the serum IS level can be used to predict the risk of major adverse CV events (MACEs) in patients with chronic kidney disease (CKD). METHODS: We studied 147 patients with CKD stage 1-5 over a 3-year follow-up period. IS was measured through mass spectrometry. Patients' demographics were collected and analyzed to predict outcomes by using multivariable Cox regression. RESULTS: Forty-seven (32.0%) patients had MACEs. IS remained significantly associated with MACEs after multivariable regression analysis. The area under the receiver operating characteristic curve for IS levels was 0.708 (95% confidence interval: 0.618-0.798). CONCLUSION:IS may have a critical role in the prediction of CV disease in patients with CKD. Further large-scale investigations are warranted and suggested.
Authors: Raul Sanchez-Gimenez; Wahiba Ahmed-Khodja; Yesica Molina; Oscar M Peiró; Gil Bonet; Anna Carrasquer; George A Fragkiadakis; Mònica Bulló; Alfredo Bardaji; Christopher Papandreou Journal: Nutrients Date: 2022-06-27 Impact factor: 6.706