Literature DB >> 30915442

Sex differences in cytokine production following West Nile virus infection: Implications for symptom manifestation.

Kevin W Hoffman1,2, Jakleen J Lee1,2, Gregory A Foster3, David Krysztof3, Susan L Stramer3, Jean K Lim1.   

Abstract

West Nile virus (WNV) infection outcomes vary among individuals, with most infections resulting in asymptomatic or mild flu-like symptoms. We previously reported an association between early cytokine production and symptom outcome following WNV infection in US blood donors. In this meta-analysis, we found that WNV-infected females reported more symptoms than WNV-infected males, despite similar initial viremia and type I interferon responses. As the infection progressed, males exhibited a protracted cytokine response-marked by sustained CCL2 (MCP-1), CCL11 (eotaxin-1), CXCL10 (IP-10) and IL-15-that was absent in females. Our results suggest that sex differences may be a factor in sustaining WNV immunity. © FEMS 2019.

Entities:  

Keywords:  blood bank; blood donations; clinical outcome; cytokines; sex differences; susceptibility

Mesh：

Substances：

Year:  2019        PMID： 30915442      PMCID： PMC6465207          DOI： 10.1093/femspd/ftz016

Source DB:  PubMed          Journal:  Pathog Dis        ISSN： 2049-632X            Impact factor:   3.166


  18 in total

1.  Interleukin-15 (IL-15) induces IL-8 and monocyte chemotactic protein 1 production in human monocytes.

Authors:  R Badolato; A N Ponzi; M Millesimo; L D Notarangelo; T Musso
Journal:  Blood       Date:  1997-10-01       Impact factor: 22.113

2.  Induction of IL-15 messenger RNA and protein in human blood-derived dendritic cells: a role for IL-15 in attraction of T cells.

Authors:  H Jonuleit; K Wiedemann; G Müller; J Degwert; U Hoppe; J Knop; A H Enk
Journal:  J Immunol       Date:  1997-03-15       Impact factor: 5.422

3.  Human pDCs display sex-specific differences in type I interferon subtypes and interferon α/β receptor expression.

Authors:  Susanne M Ziegler; Claudia Beisel; Kathrin Sutter; Morgane Griesbeck; Heike Hildebrandt; Sven H Hagen; Ulf Dittmer; Marcus Altfeld
Journal:  Eur J Immunol       Date:  2017-01-03       Impact factor: 5.532

4.  Chemokine receptor Ccr2 is critical for monocyte accumulation and survival in West Nile virus encephalitis.

Authors:  Jean K Lim; Christopher J Obara; Aymeric Rivollier; Alexander G Pletnev; Brian L Kelsall; Philip M Murphy
Journal:  J Immunol       Date:  2010-12-03       Impact factor: 5.422

Review 5.  Sex Drives Dimorphic Immune Responses to Viral Infections.

Authors:  Soumitra Ghosh; Robyn S Klein
Journal:  J Immunol       Date:  2017-03-01       Impact factor: 5.422

6.  Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis.

Authors:  Robyn S Klein; Eugene Lin; Bo Zhang; Andrew D Luster; Judy Tollett; Melanie A Samuel; Michael Engle; Michael S Diamond
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

Review 7.  The continuing spread of West Nile virus in the western hemisphere.

Authors:  Duane J Gubler
Journal:  Clin Infect Dis       Date:  2007-09-14       Impact factor: 9.079

8.  Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection.

Authors:  William G Glass; Jean K Lim; Rushina Cholera; Alexander G Pletnev; Ji-Liang Gao; Philip M Murphy
Journal:  J Exp Med       Date:  2005-10-17       Impact factor: 14.307

9.  Chemoattraction of human blood T lymphocytes by interleukin-15.

Authors:  P C Wilkinson; F Y Liew
Journal:  J Exp Med       Date:  1995-03-01       Impact factor: 14.307

10.  West Nile Virus and Other Nationally Notifiable Arboviral Diseases - United States, 2017.

Authors:  Emily J Curren; Jennifer Lehman; Jonathan Kolsin; William L Walker; Stacey W Martin; J Erin Staples; Susan L Hills; Carolyn V Gould; Ingrid B Rabe; Marc Fischer; Nicole P Lindsey
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2018-10-19       Impact factor: 17.586
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  3 in total

1.  Serum Cytokines Predict Neurological Damage in Genetically Diverse Mouse Models.

Authors:  Aracely A Pérez Gómez; Moumita Karmakar; Raymond J Carroll; Koedi S Lawley; Katia Amstalden; Colin R Young; David W Threadgill; C Jane Welsh; Candice Brinkmeyer-Langford
Journal:  Cells       Date:  2022-06-28       Impact factor: 7.666

2.  Disruption of type I interferon signaling causes sexually dimorphic dysregulation of anti-viral cytokines.

Authors:  Maedeh Darzianiazizi; Katrina E Allison; Raveendra R Kulkarni; Shayan Sharif; Khalil Karimi; Byram W Bridle
Journal:  Cytokine X       Date:  2021-06-06

3.  Severe West Nile Virus Neuroinvasive Disease: Clinical Characteristics, Short- and Long-Term Outcomes.

Authors:  Marija Santini; Sara Haberle; Snježana Židovec-Lepej; Vladimir Savić; Marija Kusulja; Neven Papić; Klaudija Višković; Ivana Župetić; Giovanni Savini; Ljubo Barbić; Irena Tabain; Marko Kutleša; Vladimir Krajinović; Tanja Potočnik-Hunjadi; Elizabeta Dvorski; Tamara Butigan; Gordana Kolaric-Sviben; Vladimir Stevanović; Lana Gorenec; Ivana Grgić; Filip Glavač; Armin Mehmedović; Eddy Listeš; Tatjana Vilibić-Čavlek
Journal:  Pathogens       Date:  2022-01-02
  3 in total

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