Rahul Lakhotia1, Anita Aggarwal2, Mary E Link3, Griffin P Rodgers4, Matthew M Hsieh5. 1. Hematology Branch, NHLBI, NIH, United States of America. Electronic address: Rahul.lakhotia@nih.gov. 2. Department of Hematology and Oncology, Veterans Administration Hospital, Washington DC, United States of America. Electronic address: anita.aggarwal@va.gov. 3. Molecular and Clinical Hematology Branch, NHLBI, NIH, United States of America. Electronic address: mary.link@nih.gov. 4. Molecular and Clinical Hematology Branch, NHLBI, NIH, United States of America. Electronic address: Gr5n@nih.gov. 5. Molecular and Clinical Hematology Branch, NHLBI, NIH, United States of America. Electronic address: matthewhs@mail.nih.gov.
Abstract
BACKGROUND: Benign ethnic neutropenia (BEN), defined by neutrophil count <1.5 k/μL in the absence of other causes, is an asymptomatic condition more commonly observed in individuals of African ancestry. However, the natural history of this condition has been less well described. METHODS: Individuals with BEN were retrospectively identified by chart review or referral to hematology clinics. They were then invited to enroll in a prospective natural history study. Retrospective and prospective clinical and laboratory data were combined for descriptive analyses. FINDINGS: 46 participants, younger and older adults from 2 institutions, had BEN. Hypertension was reported in 30%, musculoskeletal disorders in 15%, and upper respiratory infection in 33% of these adults. Their leukopenia resulted from isolated neutropenia, ranging from 1000 and 1500 cells/μL. The severity of infections was mild and the frequency was similar to other healthy individuals in the ambulatory clinic. INTERPRETATION: In this group of BEN participants, their leukopenia was stable over time, and they had low rates of infections or common medical disorders, confirming the benign nature of this condition. The presence of BEN in children, younger adults, and older adults suggest a hereditary pattern for BEN. Published by Elsevier Inc.
BACKGROUND:Benign ethnic neutropenia (BEN), defined by neutrophil count <1.5 k/μL in the absence of other causes, is an asymptomatic condition more commonly observed in individuals of African ancestry. However, the natural history of this condition has been less well described. METHODS: Individuals with BEN were retrospectively identified by chart review or referral to hematology clinics. They were then invited to enroll in a prospective natural history study. Retrospective and prospective clinical and laboratory data were combined for descriptive analyses. FINDINGS: 46 participants, younger and older adults from 2 institutions, had BEN. Hypertension was reported in 30%, musculoskeletal disorders in 15%, and upper respiratory infection in 33% of these adults. Their leukopenia resulted from isolated neutropenia, ranging from 1000 and 1500 cells/μL. The severity of infections was mild and the frequency was similar to other healthy individuals in the ambulatory clinic. INTERPRETATION: In this group of BEN participants, their leukopenia was stable over time, and they had low rates of infections or common medical disorders, confirming the benign nature of this condition. The presence of BEN in children, younger adults, and older adults suggest a hereditary pattern for BEN. Published by Elsevier Inc.
Authors: C L Dinardo; M N Kerbauy; T C Santos; W M Lima; M R Dezan; V B Oliveira; A Mendrone-Júnior; V Rocha; E D R P Velloso Journal: Int J Lab Hematol Date: 2017-07-10 Impact factor: 2.877
Authors: Jin Li; Joseph T Glessner; Haitao Zhang; Cuiping Hou; Zhi Wei; Jonathan P Bradfield; Frank D Mentch; Yiran Guo; Cecilia Kim; Qianghua Xia; Rosetta M Chiavacci; Kelly A Thomas; Haijun Qiu; Struan F A Grant; Susan L Furth; Hakon Hakonarson; Patrick M A Sleiman Journal: Hum Mol Genet Date: 2012-12-20 Impact factor: 6.150
Authors: Matthew M Hsieh; James E Everhart; Danita D Byrd-Holt; John F Tisdale; Griffin P Rodgers Journal: Ann Intern Med Date: 2007-04-03 Impact factor: 25.391
Authors: David Reich; Michael A Nalls; W H Linda Kao; Ermeg L Akylbekova; Arti Tandon; Nick Patterson; James Mullikin; Wen-Chi Hsueh; Ching-Yu Cheng; Josef Coresh; Eric Boerwinkle; Man Li; Alicja Waliszewska; Julie Neubauer; Rongling Li; Tennille S Leak; Lynette Ekunwe; Joe C Files; Cheryl L Hardy; Joseph M Zmuda; Herman A Taylor; Elad Ziv; Tamara B Harris; James G Wilson Journal: PLoS Genet Date: 2009-01-30 Impact factor: 5.917
Authors: Johan Duchene; Igor Novitzky-Basso; Aude Thiriot; Maria Casanova-Acebes; Mariaelvy Bianchini; S Leah Etheridge; Elin Hub; Katrin Nitz; Katharina Artinger; Kathrin Eller; Jorge Caamaño; Thomas Rülicke; Paul Moss; Remco T A Megens; Ulrich H von Andrian; Andres Hidalgo; Christian Weber; Antal Rot Journal: Nat Immunol Date: 2017-05-29 Impact factor: 25.606
Authors: Bashira A Charles; Matthew M Hsieh; Adebowale A Adeyemo; Daniel Shriner; Edward Ramos; Kyung Chin; Kshitij Srivastava; Neil A Zakai; Mary Cushman; Leslie A McClure; Virginia Howard; Willy A Flegel; Charles N Rotimi; Griffin P Rodgers Journal: PLoS One Date: 2018-03-29 Impact factor: 3.240
Authors: Alyson L Dickson; Laura L Daniel; Elise Jackson; Jacy Zanussi; Wenjian Yang; W Dale Plummer; William D Dupont; Wei-Qi Wei; Puran Nepal; Adriana M Hung; Nancy J Cox; Sara L Van Driest; QiPing Feng; Jun J Yang; C Michael Stein; Jonathan D Mosley; Cecilia P Chung Journal: Ann Intern Med Date: 2022-06-21 Impact factor: 51.598
Authors: Scott C Borinstein; David Agamasu; Jonathan S Schildcrout; Lisa Bastarache; Minoo Bagheri; Lea K Davis; Dan M Roden; C Michael Stein; Sara L Van Driest; Jonathan D Mosley Journal: J Cell Mol Med Date: 2022-06-01 Impact factor: 5.295
Authors: Teri A Manolio; Carol J Bult; Rex L Chisholm; Patricia A Deverka; Geoffrey S Ginsburg; Madison Goldrich; Gail P Jarvik; George A Mensah; Erin M Ramos; Mary V Relling; Dan M Roden; Robb Rowley; Marc S Williams; Eric D Green Journal: Am J Hum Genet Date: 2021-12-02 Impact factor: 11.043
Authors: Husain Y Alkhaldy; Zuhier A Awan; Ahmed A Abouzaid; Hossameldin M Elbahaie; Saeed M Al Amoudi; Mohamed Andarawi; Shehata F Shehata Journal: Int J Gen Med Date: 2020-12-03
Authors: Phumla Sinxadi; Cristina Donini; Hilary Johnstone; Grant Langdon; Lubbe Wiesner; Elizabeth Allen; Stephan Duparc; Stephan Chalon; James S McCarthy; Ulrike Lorch; Kelly Chibale; Jörg Möhrle; Karen I Barnes Journal: Antimicrob Agents Chemother Date: 2020-03-24 Impact factor: 5.191
Authors: Naomi Alpert; Joseph L Rapp; John Mascarenhas; Eileen Scigliano; Douglas Tremblay; Bridget K Marcellino; Emanuela Taioli Journal: Front Oncol Date: 2020-11-20 Impact factor: 6.244