Literature DB >> 30906622

The metabolic modulator PGC-1α in cancer.

Frederic Bost1, Lisa Kaminski1.   

Abstract

The peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is a central modulator of cell metabolism. It regulates mitochondrial biogenesis and oxidative metabolism. Modifications and adaptations in cellular metabolism are hallmarks of cancer cells, thus, it is not surprising that PGC-1α plays a role in cancer. Several recent articles have shown that PGC-1α expression is altered in tumors and metastasis in relation to modifications in cellular metabolism. The potential uses of PGC-1α as a therapeutic target and a biomarker of the advanced form of cancer will be summarized in this review.

Entities:  

Keywords:  PGC1 alpha; breast cancer; melanoma; metabolism; mitochondria; pancreatic cancer; prostate cancer

Year:  2019        PMID： 30906622      PMCID： PMC6405967     

Source DB:  PubMed          Journal:  Am J Cancer Res        ISSN： 2156-6976            Impact factor:   6.166


  49 in total

Review 1.  The Mitochondrion as an Emerging Therapeutic Target in Cancer.

Authors:  Katherine G Roth; Isa Mambetsariev; Prakash Kulkarni; Ravi Salgia
Journal:  Trends Mol Med       Date:  2019-07-18       Impact factor: 11.951

Review 2.  Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?

Authors:  Alexis Diaz-Vegas; Pablo Sanchez-Aguilera; James R Krycer; Pablo E Morales; Matías Monsalves-Alvarez; Mariana Cifuentes; Beverly A Rothermel; Sergio Lavandero
Journal:  Endocr Rev       Date:  2020-06-01       Impact factor: 19.871

3.  PGC1α Inhibits Polyamine Synthesis to Suppress Prostate Cancer Aggressiveness.

Authors:  Lisa Kaminski; Stéphanie Torrino; Maeva Dufies; Zied Djabari; Romain Haider; François-René Roustan; Emilie Jaune; Kathiane Laurent; Nicolas Nottet; Jean-François Michiels; Maeva Gesson; Stéphane Rocchi; Nathalie M Mazure; Matthieu Durand; Jean-François Tanti; Damien Ambrosetti; Stephan Clavel; Issam Ben-Sahra; Frédéric Bost
Journal:  Cancer Res       Date:  2019-05-07       Impact factor: 12.701

Review 4.  Targeting PGC1α to wrestle cancer: a compelling therapeutic opportunity.

Authors:  Xiangyu Sun; Xiaoyan Liu; Keda Yu; Shouping Xu; Pengfei Qiu; Zhidong Lv; Xinwen Zhang; Yingying Xu
Journal:  J Cancer Res Clin Oncol       Date:  2022-01-15       Impact factor: 4.553

5.  Construction of a ceRNA network in hepatocellular carcinoma and comprehensive analysis of immune infiltration patterns.

Authors:  Zhifan Zuo; Tingsong Chen; Yue Zhang; Lei Han; Bo Liu; Bin Yang; Tao Han; Zhendong Zheng
Journal:  Am J Transl Res       Date:  2021-12-15       Impact factor: 4.060

6.  Pulmonary arterial hypertension induces the release of circulating extracellular vesicles with oxidative content and alters redox and mitochondrial homeostasis in the brains of rats.

Authors:  Giana Blume Corssac; Jéssica Poletto Bonetto; Cristina Campos-Carraro; Laura Reck Cechinel; Alexsandra Zimmer; Belisa Parmeggiani; Mateus Grings; Virgínia Mendes Carregal; André Ricardo Massensini; Ionara Siqueira; Guilhian Leipnitz; Adriane Belló-Klein
Journal:  Hypertens Res       Date:  2021-04-19       Impact factor: 3.872

Review 7.  Metabolic Strategies for Inhibiting Cancer Development.

Authors:  Philippe Icard; Mauro Loi; Zherui Wu; Antonin Ginguay; Hubert Lincet; Edouard Robin; Antoine Coquerel; Diana Berzan; Ludovic Fournel; Marco Alifano
Journal:  Adv Nutr       Date:  2021-07-30       Impact factor: 8.701

8.  Ginsenoside-Rg2 exerts anti-cancer effects through ROS-mediated AMPK activation associated mitochondrial damage and oxidation in MCF-7 cells.

Authors:  Hyesu Jeon; Yujin Jin; Chang-Seon Myung; Kyung-Sun Heo
Journal:  Arch Pharm Res       Date:  2021-07-24       Impact factor: 4.946

Review 9.  AdipoRon and Other Adiponectin Receptor Agonists as Potential Candidates in Cancer Treatments.

Authors:  Ersilia Nigro; Aurora Daniele; Alessia Salzillo; Angela Ragone; Silvio Naviglio; Luigi Sapio
Journal:  Int J Mol Sci       Date:  2021-05-25       Impact factor: 5.923

10.  PGC1α-Mediated Metabolic Reprogramming Drives the Stemness of Pancreatic Precursor Lesions.

Authors:  Rama Krishna Nimmakayala; Sanchita Rauth; Ramakanth Chirravuri Venkata; Saravanakumar Marimuthu; Palanisamy Nallasamy; Raghupathy Vengoji; Subodh M Lele; Satyanarayana Rachagani; Kavita Mallya; Mokenge P Malafa; Moorthy P Ponnusamy; Surinder K Batra
Journal:  Clin Cancer Res       Date:  2021-10-01       Impact factor: 12.531
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