Literature DB >> 32910329

Advances in the Genetics and Genomics of Heart Failure.

Nosheen Reza1, Anjali Tiku Owens2.   

Abstract

PURPOSE OF REVIEW: The purpose of this review is to provide an update on the recent advances in the genetics and genomics of dilated cardiomyopathy and heart failure. RECENT
FINDINGS: Over the last decade, the approach to the discovery of the genetic contribution to heart failure has evolved from investigation of rare variants implicated in Mendelian cardiomyopathies through linkage studies and candidate gene studies to the exploration of the contribution of common variants through large-scale genome-wide association and genome-first studies. The combination and integration of multiple of case-control heart failure cohorts, refinement of the heart failure phenotype, and utilization of large biobanks linked to electronic health records have advanced the understanding of the heritability of heart failure.

Entities:  

Keywords:  Dilated cardiomyopathy; Genetics; Genomics; Heart failure; Pharmacogenomics

Mesh：

Year:  2020        PMID： 32910329      PMCID： PMC7713504          DOI： 10.1007/s11886-020-01385-z

Source DB:  PubMed          Journal:  Curr Cardiol Rep        ISSN： 1523-3782            Impact factor:   2.931


  49 in total

1.  Disparities in Cardiovascular Mortality Related to Heart Failure in the United States.

Authors:  Peter Glynn; Donald M Lloyd-Jones; Matthew J Feinstein; Mercedes Carnethon; Sadiya S Khan
Journal:  J Am Coll Cardiol       Date:  2019-05-14       Impact factor: 24.094

2.  Heart Failure in the Era of Precision Medicine: A Scientific Statement From the American Heart Association.

Authors:  Sharon Cresci; Naveen L Pereira; Ferhaan Ahmad; Mirnela Byku; Lisa de Las Fuentes; David E Lanfear; Carolyn M Reilly; Anjali T Owens; Matthew J Wolf
Journal:  Circ Genom Precis Med       Date:  2019-09-12

3.  Genome-wide association study of cardiac structure and systolic function in African Americans: the Candidate Gene Association Resource (CARe) study.

Authors:  Ervin R Fox; Solomon K Musani; Maja Barbalic; Honghuang Lin; Bing Yu; Kofo O Ogunyankin; Nicholas L Smith; Abdullah Kutlar; Nicole L Glazer; Wendy S Post; Dina N Paltoo; Daniel L Dries; Deborah N Farlow; Christine W Duarte; Sharon L Kardia; Kristin J Meyers; Yan V Sun; Donna K Arnett; Amit A Patki; Jin Sha; Xiangqui Cui; Tandaw E Samdarshi; Alan D Penman; Kirsten Bibbins-Domingo; Petra Bůžková; Emelia J Benjamin; David A Bluemke; Alanna C Morrison; Gerardo Heiss; J Jeffrey Carr; Russell P Tracy; Thomas H Mosley; Herman A Taylor; Bruce M Psaty; Susan R Heckbert; Thomas P Cappola; Ramachandran S Vasan
Journal:  Circ Cardiovasc Genet       Date:  2012-12-28

4.  A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy.

Authors:  Eric Villard; Claire Perret; Françoise Gary; Carole Proust; Gilles Dilanian; Christian Hengstenberg; Volker Ruppert; Eloisa Arbustini; Thomas Wichter; Marine Germain; Olivier Dubourg; Luigi Tavazzi; Marie-Claude Aumont; Pascal DeGroote; Laurent Fauchier; Jean-Noël Trochu; Pierre Gibelin; Jean-François Aupetit; Klaus Stark; Jeanette Erdmann; Roland Hetzer; Angharad M Roberts; Paul J R Barton; Vera Regitz-Zagrosek; Uzma Aslam; Laëtitia Duboscq-Bidot; Matthias Meyborg; Bernhard Maisch; Hugo Madeira; Anders Waldenström; Enrique Galve; John G Cleland; Richard Dorent; Gerard Roizes; Tanja Zeller; Stefan Blankenberg; Alison H Goodall; Stuart Cook; David A Tregouet; Laurence Tiret; Richard Isnard; Michel Komajda; Philippe Charron; François Cambien
Journal:  Eur Heart J       Date:  2011-04-01       Impact factor: 29.983

5.  Effect of bucindolol on heart failure outcomes and heart rate response in patients with reduced ejection fraction heart failure and atrial fibrillation.

Authors:  David P Kao; Gordon Davis; Ryan Aleong; Christopher M O'Connor; Mona Fiuzat; Peter E Carson; Inder S Anand; Jonathan F Plehn; Stephen S Gottlieb; Marc A Silver; JoAnn Lindenfeld; Alan B Miller; Michel White; Guinevere A Murphy; Will Sauer; Michael R Bristow
Journal:  Eur J Heart Fail       Date:  2012-12-07       Impact factor: 15.534

Review 6.  Pharmacogenomics in heart failure: where are we now and how can we reach clinical application?

Authors:  Akinyemi Oni-Orisan; David E Lanfear
Journal:  Cardiol Rev       Date:  2014 Sep-Oct       Impact factor: 2.644

7.  Demonstrating the pharmacogenetic effects of angiotensin-converting enzyme inhibitors on long-term prognosis of diastolic heart failure.

Authors:  C-K Wu; J-L Luo; C-T Tsai; Y-T Huang; C-L Cheng; J-K Lee; L-Y Lin; J-W Lin; J-J Hwang; F-T Chiang
Journal:  Pharmacogenomics J       Date:  2009-09-15       Impact factor: 3.550

8.  A genome-first approach to aggregating rare genetic variants in LMNA for association with electronic health record phenotypes.

Authors:  Joseph Park; Michael G Levin; Christopher M Haggerty; Dustin N Hartzel; Renae Judy; Rachel L Kember; Nosheen Reza; Marylyn D Ritchie; Anjali T Owens; Scott M Damrauer; Daniel J Rader
Journal:  Genet Med       Date:  2019-08-06       Impact factor: 8.822

9.  Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure.

Authors:  J Gustav Smith; Janine F Felix; Alanna C Morrison; Andreas Kalogeropoulos; Stella Trompet; Jemma B Wilk; Olof Gidlöf; Xinchen Wang; Michael Morley; Michael Mendelson; Roby Joehanes; Symen Ligthart; Xiaoyin Shan; Joshua C Bis; Ying A Wang; Marketa Sjögren; Julius Ngwa; Jeffrey Brandimarto; David J Stott; David Aguilar; Kenneth M Rice; Howard D Sesso; Serkalem Demissie; Brendan M Buckley; Kent D Taylor; Ian Ford; Chen Yao; Chunyu Liu; Nona Sotoodehnia; Pim van der Harst; Bruno H Ch Stricker; Stephen B Kritchevsky; Yongmei Liu; J Michael Gaziano; Albert Hofman; Christine S Moravec; André G Uitterlinden; Manolis Kellis; Joyce B van Meurs; Kenneth B Margulies; Abbas Dehghan; Daniel Levy; Björn Olde; Bruce M Psaty; L Adrienne Cupples; J Wouter Jukema; Luc Djousse; Oscar H Franco; Eric Boerwinkle; Laurie A Boyer; Christopher Newton-Cheh; Javed Butler; Ramachandran S Vasan; Thomas P Cappola; Nicholas L Smith
Journal:  PLoS Genet       Date:  2016-05-05       Impact factor: 5.917

10.  The UK Biobank resource with deep phenotyping and genomic data.

Authors:  Clare Bycroft; Colin Freeman; Desislava Petkova; Gavin Band; Lloyd T Elliott; Kevin Sharp; Allan Motyer; Damjan Vukcevic; Olivier Delaneau; Jared O'Connell; Adrian Cortes; Samantha Welsh; Alan Young; Mark Effingham; Gil McVean; Stephen Leslie; Naomi Allen; Peter Donnelly; Jonathan Marchini
Journal:  Nature       Date:  2018-10-10       Impact factor: 49.962
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