Literature DB >> 3090009

Comparison of the effect of phenoxymethylpenicillin, cloxacillin, and flucloxacillin on Staphylococcus aureus phagocytosed by human monocytes.

P J van den Broek, L F Buys, H Mattie, R van Furth.   

Abstract

The antibacterial effect of phenoxymethylpenicillin, cloxacillin, and flucloxacillin on pre-opsonized Staphylococcus aureus ingested by human monocytes and on preopsonized S. aureus in suspension was compared. The antibiotics were 1.7-3 times more effective against intracellular S. aureus than against S. aureus in suspension. No influence of acid stability or lipid solubility of the drugs on the antibacterial effect against intracellular S. aureus was demonstrated.

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Year:  1986        PMID： 3090009     DOI： 10.1093/jac/17.6.767

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  3 in total

Review 1.  Activity of antibiotics against microorganisms ingested by mononuclear phagocytes.

Authors:  P J van den Broek
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1991-02       Impact factor: 3.267

2.  Uptake of cefepime by phagocytosing polymorphonuclear neutrophils and subsequent intracellular killing.

Authors:  H Pruul; P J McDonald
Journal:  Antimicrob Agents Chemother       Date:  1996-08       Impact factor: 5.191

3.  Pharmacodynamic evaluation of the intracellular activities of antibiotics against Staphylococcus aureus in a model of THP-1 macrophages.

Authors:  Maritza Barcia-Macay; Cristina Seral; Marie-Paule Mingeot-Leclercq; Paul M Tulkens; Françoise Van Bambeke
Journal:  Antimicrob Agents Chemother       Date:  2006-03       Impact factor: 5.191
  3 in total

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