Literature DB >> 1864273

Activity of antibiotics against microorganisms ingested by mononuclear phagocytes.

P J van den Broek1.   

Abstract

The data available on the activity of antibiotics against microorganisms ingested by mononuclear phagocytes are reviewed. The antibacterial activity of penicillins against Staphylococcus aureus is enhanced by human monocytes. This enhancement is possibly brought about by a peptidoglycan-degrading enzyme that is produced and secreted by monocytes. Aminoglycosides affect bacteria ingested by mononuclear phagocytes, but their intracellular activity is limited as compared with that of non-phagocytosed bacteria. Clindamycin, erythromycin, ciprofloxacin and rifampicin are effective against intracellular bacteria. The first three of these antibiotics do not show enhanced activity against phagocytosed bacteria, contrary to what might be expected from their high cell-associated concentrations.

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Year:  1991        PMID： 1864273     DOI： 10.1007/bf01964422

Source DB:  PubMed          Journal:  Eur J Clin Microbiol Infect Dis        ISSN： 0934-9723            Impact factor:   3.267


  39 in total

1.  The bactericidal action of isoniazid, streptomycin and terramycin on extracellular and intracellular tubercle bacilli.

Authors:  G B MACKANESS; N SMITH
Journal:  Am Rev Tuberc       Date:  1953-03

2.  Killing of macrophage-ingested mycobacteria by rifampicin, pyrazinamide, and pyrazinoic acid alone and in combination.

Authors:  N A Carlone; G Acocella; A M Cuffini; M Forno-Pizzoglio
Journal:  Am Rev Respir Dis       Date:  1985-12

3.  Intracellular killing of Listeria monocytogenes by activated macrophages (Mackaness system) is due to antibiotic.

Authors:  P Cole; J Brostoff
Journal:  Nature       Date:  1975-08-07       Impact factor: 49.962

4.  Antibiotic susceptibility of Legionella pneumophia Philadelphia-1 in cultured guinea-pig peritoneal macrophages.

Authors:  S Yoshida; Y Mizuguchi
Journal:  J Gen Microbiol       Date:  1984-04

5.  Effect of rifabutin on the phagocytosis and intracellular growth of Mycobacterium intracellulare in mouse resident and activated peritoneal and alveolar macrophages.

Authors:  V K Perumal; P R Gangadharam; M D Iseman
Journal:  Am Rev Respir Dis       Date:  1987-08

6.  Effect of ciprofloxacin on intracellular organisms: in-vitro and in-vivo studies.

Authors:  C S Easmon; J P Crane; A Blowers
Journal:  J Antimicrob Chemother       Date:  1986-11       Impact factor: 5.790

7.  Multiplication of Mycobacterium tuberculosis Within Normal and "Immune" Mouse Macrophages Cultivated With and Without Streptomycin.

Authors:  R J Patterson; G P Youmans
Journal:  Infect Immun       Date:  1970-01       Impact factor: 3.441

8.  In vitro interactions between rabbit alveolar macrophages and Pasteurella tularensis.

Authors:  J E Nutter; Q N Myrvik
Journal:  J Bacteriol       Date:  1966-09       Impact factor: 3.490

9.  Interaction between human monocytes and penicillin G in relation to the antibacterial effect on Staphylococcus aureus.

Authors:  P J van den Broek; L F Buys; M T van den Barselaar; P C Leijh; R van Furth
Journal:  J Infect Dis       Date:  1985-09       Impact factor: 5.226

10.  In vitro synthesis and secretion of lysozyme by mononuclear phagocytes.

Authors:  S Gordon; J Todd; Z A Cohn
Journal:  J Exp Med       Date:  1974-05-01       Impact factor: 14.307
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  11 in total

Review 1.  Interference of antibacterial agents with phagocyte functions: immunomodulation or "immuno-fairy tales"?

Authors:  M T Labro
Journal:  Clin Microbiol Rev       Date:  2000-10       Impact factor: 26.132

2.  Phagocytes, antibiotics and intracellular parasites: are the experimental data clinically relevant?

Authors:  J C Pechère
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1991-02       Impact factor: 3.267

3.  Generation of a Stable Plasmid for In Vitro and In Vivo Studies of Staphylococcus Species.

Authors:  Christina N Krute; Kelsey L Krausz; Mary A Markiewicz; Jason A Joyner; Srijana Pokhrel; Pamela R Hall; Jeffrey L Bose
Journal:  Appl Environ Microbiol       Date:  2016-09-16       Impact factor: 4.792

4.  Cationic antimicrobial peptide LL-37 is effective against both extra- and intracellular Staphylococcus aureus.

Authors:  Jabeen Noore; Adly Noore; Bingyun Li
Journal:  Antimicrob Agents Chemother       Date:  2012-12-28       Impact factor: 5.191

5.  In Vitro Anti-inflammatory and Immunomodulatory Effects of Ciprofloxacin or Azithromycin in Staphylococcus aureus-Stimulated Murine Macrophages are Beneficial in the Presence of Cytochalasin D.

Authors:  Somrita Dey; Arnab Majhi; Sayantika Mahanti; Ipsita Dey; Biswadev Bishayi
Journal:  Inflammation       Date:  2015       Impact factor: 4.092

6.  Enhanced antibacterial effect of ceftriaxone sodium-loaded chitosan nanoparticles against intracellular Salmonella typhimurium.

Authors:  Noha M Zaki; Mohamed M Hafez
Journal:  AAPS PharmSciTech       Date:  2012-02-23       Impact factor: 3.246

7.  Uptake of cefepime by phagocytosing polymorphonuclear neutrophils and subsequent intracellular killing.

Authors:  H Pruul; P J McDonald
Journal:  Antimicrob Agents Chemother       Date:  1996-08       Impact factor: 5.191

8.  Expression of lysostaphin in HeLa cells protects from host cell killing by intracellular Staphylococcus aureus.

Authors:  Marcus Klein; Martin Krönke; Oleg Krut
Journal:  Med Microbiol Immunol       Date:  2006-02-16       Impact factor: 3.402

9.  Pharmacodynamic evaluation of the intracellular activities of antibiotics against Staphylococcus aureus in a model of THP-1 macrophages.

Authors:  Maritza Barcia-Macay; Cristina Seral; Marie-Paule Mingeot-Leclercq; Paul M Tulkens; Françoise Van Bambeke
Journal:  Antimicrob Agents Chemother       Date:  2006-03       Impact factor: 5.191

10.  Quantitative analysis of gentamicin, azithromycin, telithromycin, ciprofloxacin, moxifloxacin, and oritavancin (LY333328) activities against intracellular Staphylococcus aureus in mouse J774 macrophages.

Authors:  Cristina Seral; Françoise Van Bambeke; Paul M Tulkens
Journal:  Antimicrob Agents Chemother       Date:  2003-07       Impact factor: 5.191
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