Literature DB >> 3089902

Altered cellular response to UV irradiation in a patient affected by premature ageing.

M Stefanini, G Orecchia, G Rabbiosi, F Nuzzo.   

Abstract

An abnormal response to UV-irradiation was found in a patient affected by precocious senescence. A decreased level of unscheduled DNA synthesis (UDS) was present in 60% of Go lymphocytes and in fibroblasts after the fifth culture passage. Hypersensitivity of lymphocytes to UV-light was indicated also by a decreased rate of DNA synthesis after mitogen stimulation. The results of this study indicate that the defect which determines the premature ageing influences the capacity to repair UV-induced DNA damage.

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Year:  1986        PMID： 3089902     DOI： 10.1007/bf00401225

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  17 in total

Review 1.  Xeroderma pigmentosum: biochemical and genetic characteristics.

Authors:  J E Cleaver; D Bootsma
Journal:  Annu Rev Genet       Date:  1975       Impact factor: 16.830

2.  Normal level of unscheduled DNA synthesis in Werner's syndrome fibroblasts in culture.

Authors:  T Higashikawa; Y Fujiwara
Journal:  Exp Cell Res       Date:  1978-05       Impact factor: 3.905

Review 3.  Repair deficient human disorders and cancer.

Authors:  R B Setlow
Journal:  Nature       Date:  1978-02-23       Impact factor: 49.962

4.  DNA repair in skin of lupus erythematosus following in vivo exposure to ultraviolet radiation.

Authors:  S M D'Ambrosio; E Bisaccia; J W Whetstone; D A Scarborough; E Lowney
Journal:  J Invest Dermatol       Date:  1983-11       Impact factor: 8.551

5.  Abnormal responses to mid-ultraviolet light of cultured fibroblasts from patients with disorders featuring sunlight sensitivity.

Authors:  P J Smith; M C Paterson
Journal:  Cancer Res       Date:  1981-02       Impact factor: 12.701

6.  Differences in the levels of UV repair and in clinical symptoms in two sibs affected by xeroderma pigmentosum.

Authors:  M Stefanini; W Keijzer; L Dalprà; R Elli; M N Porro; B Nicoletti; F Nuzzo
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

7.  Age-related changes in human thymus.

Authors:  J Singh; A K Singh
Journal:  Clin Exp Immunol       Date:  1979-09       Impact factor: 4.330

8.  A new human photosensitive subject with a defect in the recovery of DNA synthesis after ultraviolet-light irradiation.

Authors:  Y Fujiwara; M Ichihashi; Y Kano; K Goto; K Shimizu
Journal:  J Invest Dermatol       Date:  1981-09       Impact factor: 8.551

9.  Multiple hypersensitivity to mutagens in a cell strain (46BR) derived from a patient with immuno-deficiencies.

Authors:  I A Teo; C F Arlett; S A Harcourt; A Priestley; B C Broughton
Journal:  Mutat Res       Date:  1983-02       Impact factor: 2.433

10.  Decreased UV-induced DNA repair synthesis in peripheral leukocytes from patients with the nevoid basal cell carcinoma syndrome.

Authors:  U Ringborg; B Lambert; J Landergen; R Lewensohn
Journal:  J Invest Dermatol       Date:  1981-04       Impact factor: 8.551
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  3 in total

1.  Slowly progressing nucleotide excision repair in trichothiodystrophy group A patient fibroblasts.

Authors:  Arjan F Theil; Julie Nonnekens; Nils Wijgers; Wim Vermeulen; Giuseppina Giglia-Mari
Journal:  Mol Cell Biol       Date:  2011-07-05       Impact factor: 4.272

2.  Xeroderma pigmentosum (complementation group D) mutation is present in patients affected by trichothiodystrophy with photosensitivity.

Authors:  M Stefanini; P Lagomarsini; C F Arlett; S Marinoni; C Borrone; F Crovato; G Trevisan; G Cordone; F Nuzzo
Journal:  Hum Genet       Date:  1986-10       Impact factor: 4.132

3.  GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy.

Authors:  Christiane Kuschal; Elena Botta; Donata Orioli; John J Digiovanna; Sara Seneca; Kathelijn Keymolen; Deborah Tamura; Elizabeth Heller; Sikandar G Khan; Giuseppina Caligiuri; Manuela Lanzafame; Tiziana Nardo; Roberta Ricotti; Fiorenzo A Peverali; Robert Stephens; Yongmei Zhao; Alan R Lehmann; Laura Baranello; David Levens; Kenneth H Kraemer; Miria Stefanini
Journal:  Am J Hum Genet       Date:  2016-03-17       Impact factor: 11.025
  3 in total

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