Kenny Li1, Christen D Barras2, Ronil V Chandra3, Hong K Kok4, Julian T Maingard5, Nicole S Carter6, Jeremy H Russell7, Leon Lai8, Mark Brooks9, Hamed Asadi10. 1. School of Medicine, Faculty of Health, Deakin University, Geelong, Victoria, Australia. Electronic address: kenny.li@live.com.au. 2. University of Adelaide, North Terrace Campus, Adelaide, South Australia, Australia; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia. 3. Interventional Neuroradiology Service, Monash Health, Clayton, Victoria, Australia. 4. Interventional Radiology Service, Northern Health, Epping, Victoria, Australia. 5. School of Medicine, Faculty of Health, Deakin University, Geelong, Victoria, Australia; Interventional Radiology Service, Department of Radiology, Austin Hospital, Heidelberg, Victoria, Australia; Interventional Neuroradiology Service, Department of Radiology, Austin Hospital, Heidelberg, Victoria, Australia. 6. Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia. 7. Department of Neurosurgery, Austin Health, Heidelberg, Victoria, Australia. 8. Department of Neurosurgery, Monash Health, Clayton, Victoria, Australia. 9. Interventional Radiology Service, Department of Radiology, Austin Hospital, Heidelberg, Victoria, Australia; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia. 10. School of Medicine, Faculty of Health, Deakin University, Geelong, Victoria, Australia; Interventional Radiology Service, Department of Radiology, Austin Hospital, Heidelberg, Victoria, Australia; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.
Abstract
BACKGROUND: Despite decades of research, cerebral vasospasm (CV) continues to account for high morbidity and mortality in patients who survive their initial aneurysmal subarachnoid hemorrhage. OBJECTIVE: To define the scope of the problem and review key treatment strategies that have shaped the way CV is managed in the contemporary era. METHODS: A literature search was performed of CV management after aneurysmal subarachnoid hemorrhage. RESULTS: Recent advances in neuroimaging have led to improved detection of vasospasm, but established treatment guidelines including hemodynamic augmentation and interventional procedures remain highly variable among neurosurgical centers. Experimental research in subarachnoid hemorrhage continues to identify novel targets for therapy. CONCLUSIONS: Proactive and preventive strategies such as oral nimodipine and endovascular rescue therapies can reduce the morbidity and mortality associated with CV.
BACKGROUND: Despite decades of research, cerebral vasospasm (CV) continues to account for high morbidity and mortality in patients who survive their initial aneurysmal subarachnoid hemorrhage. OBJECTIVE: To define the scope of the problem and review key treatment strategies that have shaped the way CV is managed in the contemporary era. METHODS: A literature search was performed of CV management after aneurysmal subarachnoid hemorrhage. RESULTS: Recent advances in neuroimaging have led to improved detection of vasospasm, but established treatment guidelines including hemodynamic augmentation and interventional procedures remain highly variable among neurosurgical centers. Experimental research in subarachnoid hemorrhage continues to identify novel targets for therapy. CONCLUSIONS: Proactive and preventive strategies such as oral nimodipine and endovascular rescue therapies can reduce the morbidity and mortality associated with CV.
Authors: Robert S Eisinger; Zachary A Sorrentino; Brandon Lucke-Wold; Sonya Zhou; Brooke Barlow; Brian Hoh; Carolina B Maciel; Katharina M Busl Journal: Brain Inj Date: 2022-03-30 Impact factor: 2.167
Authors: T E Darsaut; C Derksen; B Farzin; M B Keough; R Fahed; W Boisseau; L Letourneau-Guillon; A-C Januel; A Weill; D Roy; T N Nguyen; S Finitsis; J-C Gentric; D Volders; A Carlson; M M Chow; C O'Kelly; J L Rempel; R A Ashforth; M Chagnon; J Zehr; J M Findlay; G Gevry; J Raymond Journal: AJNR Am J Neuroradiol Date: 2021-01-28 Impact factor: 3.825
Authors: Chunyan Li; Timothy G White; Kevin A Shah; Wayne Chaung; Keren Powell; Ping Wang; Henry H Woo; Raj K Narayan Journal: Neurosurgery Date: 2021-05-13 Impact factor: 4.654