Yi Tang1, Yi Xing2, Zude Zhu3, Yong He4, Fang Li5, Jianwei Yang2, Qing Liu6, Fangyu Li2, Stefan J Teipel7, Guoguang Zhao8, Jianping Jia9. 1. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China; Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China; Key Laboratory of Neurodegenerative Diseases, Ministry of Education of the People's Republic of China, Beijing, China. Electronic address: tangyi@xwhosp.org. 2. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China; Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China; Key Laboratory of Neurodegenerative Diseases, Ministry of Education of the People's Republic of China, Beijing, China. 3. Collaborative Innovation Center for Language Ability, Jiangsu Normal University, Xuzhou, China. 4. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing, China; Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing, China; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China. 5. Department of Geriatric, Fu Xing Hospital, Capital Medical University, Beijing, China. 6. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China; Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China. 7. Department of Psychosomatic Medicine, University Medicine Rostock, Rostock, Germany; DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany. 8. Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address: ggzhao@vip.sina.com. 9. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China; Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China; Key Laboratory of Neurodegenerative Diseases, Ministry of Education of the People's Republic of China, Beijing, China; Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China; Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China; National Clinical Research Center for Geriatric Disorders, Beijing, China; Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. Electronic address: jiajp@vip.126.com.
Abstract
INTRODUCTION: Evidence for the efficacy of cognitive training in patients with subcortical vascular cognitive impairment no dementia is still lacking. METHODS: A randomized, active controlled design using multidomain, adaptive, computerized cognitive training for 30 minutes, 5 days/week for 7 weeks. Assessments included global cognitive function and executive function (primary outcomes) and brain functional connectivity and structural changes (secondary outcomes). RESULTS:Sixty patients were randomized across three medical centers in Beijing. At the end of the intervention, the cognitive training group showed significant improvement in Montreal Cognitive Assessment relative to the active control group (P = .013) and significantly increased functional connectivity between the left dorsolateral prefrontal cortex and medial prefrontal cortex, which was significantly correlated with Montreal Cognitive Assessment change (P = .017). DISCUSSION: Computerized cognitive training significantly improved global cognitive function, which was supported by the improved brain plasticity. Incorporation of biomarkers should be implemented in cognitive training trials.
RCT Entities:
INTRODUCTION: Evidence for the efficacy of cognitive training in patients with subcortical vascular cognitive impairment no dementia is still lacking. METHODS: A randomized, active controlled design using multidomain, adaptive, computerized cognitive training for 30 minutes, 5 days/week for 7 weeks. Assessments included global cognitive function and executive function (primary outcomes) and brain functional connectivity and structural changes (secondary outcomes). RESULTS: Sixty patients were randomized across three medical centers in Beijing. At the end of the intervention, the cognitive training group showed significant improvement in Montreal Cognitive Assessment relative to the active control group (P = .013) and significantly increased functional connectivity between the left dorsolateral prefrontal cortex and medial prefrontal cortex, which was significantly correlated with Montreal Cognitive Assessment change (P = .017). DISCUSSION: Computerized cognitive training significantly improved global cognitive function, which was supported by the improved brain plasticity. Incorporation of biomarkers should be implemented in cognitive training trials.