Pavindran Arumugam Gounder1,2, David Matthew Hille1, Ying Jo Khoo1, Ravinder Singh Phagura1, Fred Kuanfu Chen1,3,4. 1. Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, Western Australia, Australia. 2. Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. 3. Ophthalmology Department, Royal Perth Hospital, Perth, Washington, Australia; and. 4. Ocular Tissue Engineering Laboratory, Lions Eye Institute, Perth, Western Australia.
Abstract
PURPOSE: To review the clinical features, microbiology spectrum, management, and outcomes of patients with endogenous endophthalmitis in Western Australia over a 16-year period. METHODS: This is a retrospective chart review of all patients with endogenous endophthalmitis who presented to all tertiary ophthalmology departments between 2000 and 2015 in Western Australia. RESULTS: Sixty-six eyes of 57 patients with endogenous endophthalmitis were identified, and follow-up data were available for a mean of 554 days. The average frequency was 1.6 per 1,000,000 population per year. Diabetes mellitus (33%) and intravenous drug use (30%) were the most common risk factors. Concurrent systemic infections included urinary tract infection (28%), pneumonia (23%), and endocarditis (21%). Among culture-positive cases (93%), 57% were bacterial and 43% were fungal. Visual acuity improved in 33 (50%) and declined in 15 eyes (22.7%). Baseline visual acuity and the presence of Gram-negative or filamentous fungi were the only predictors of final visual acuity (P = 0.023 and P = 0.001). CONCLUSION: The population frequency of endogenous endophthalmitis has not changed over 16 years despite the changing profile of pathogen and risk factors. Similar to previous studies in Asian and Western countries, visual and anatomical prognosis depends on initial visual acuity and isolated pathogen. Gram-negative and filamentous fungi culture predicted a worse visual outcome.
PURPOSE: To review the clinical features, microbiology spectrum, management, and outcomes of patients with endogenous endophthalmitis in Western Australia over a 16-year period. METHODS: This is a retrospective chart review of all patients with endogenous endophthalmitis who presented to all tertiary ophthalmology departments between 2000 and 2015 in Western Australia. RESULTS: Sixty-six eyes of 57 patients with endogenous endophthalmitis were identified, and follow-up data were available for a mean of 554 days. The average frequency was 1.6 per 1,000,000 population per year. Diabetes mellitus (33%) and intravenous drug use (30%) were the most common risk factors. Concurrent systemic infections included urinary tract infection (28%), pneumonia (23%), and endocarditis (21%). Among culture-positive cases (93%), 57% were bacterial and 43% were fungal. Visual acuity improved in 33 (50%) and declined in 15 eyes (22.7%). Baseline visual acuity and the presence of Gram-negative or filamentous fungi were the only predictors of final visual acuity (P = 0.023 and P = 0.001). CONCLUSION: The population frequency of endogenous endophthalmitis has not changed over 16 years despite the changing profile of pathogen and risk factors. Similar to previous studies in Asian and Western countries, visual and anatomical prognosis depends on initial visual acuity and isolated pathogen. Gram-negative and filamentous fungi culture predicted a worse visual outcome.
Authors: Ambar N Lugo Merly; Lorena A Montalvo Toledo; Guillermo A Requejo; Alexander Meléndez; Samuel Álvarez; Andrés López; Radames Ríos; Victor M Villegas; Armando L Oliver Journal: J Clin Med Date: 2022-06-01 Impact factor: 4.964
Authors: Seyed Ali Tabatabaei; Mohammad Soleimani; Reza Mirshahi; Bahram Bohrani; Mehdi Aminizade Journal: Int Ophthalmol Date: 2020-08-02 Impact factor: 2.031