Leah H Rubin1,2, Gayle Springer2, Eileen M Martin3, Eric C Seaberg2, Ned C Sacktor1, Andrew Levine4, Victor G Valcour5, Mary A Young6, James T Becker7, Pauline M Maki8. 1. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD. 2. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. 3. Department of Psychiatry, Rush University Medical Center, Chicago, IL. 4. Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA. 5. Department of Neurology, University of California San Francisco, San francisco, CA. 6. Department of Medicine, Georgetown University, Washington, DC. 7. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA. 8. Departments of Psychiatry and Psychology, University of Illinois at Chicago College of Medicine, Chicago, IL.
Abstract
BACKGROUND: HIV-infected (HIV+) women seem to be more vulnerable to neurocognitive impairment (NCI) than HIV+ men, perhaps in part due to mental health factors. We assessed the association between elevated depressive symptoms and NCI among HIV+ and HIV-uninfected (HIV-) women and men. SETTING: Women's Interagency HIV Study and Multicenter AIDS Cohort Study. METHODS: Eight hundred fifty-eight HIV+ (429 women; 429 men) and 562 HIV- (281 women; 281 men) completed the Center for Epidemiologic Studies Depression (16 cutoff) Scale and measures of psychomotor speed/attention, executive, and motor function over multiple visits (or time points). Women's Interagency HIV Study and Multicenter AIDS Cohort Study participants were matched according to HIV status, age, race/ethnicity, and education. Generalized linear mixed models were used to examine interactions between biological sex, HIV serostatus, and depression on impairment (T-scores <40) after covariate adjustment. RESULTS: Despite a higher frequency of depression among men, the association between depression and executive function differed by sex and HIV serostatus. HIV+ women with depression had 5 times the odds of impairment on a measure of executive control and inhibition versus HIV- depressed women and 3 times the odds of impairment on that measure versus HIV+ depressed men. Regardless of group status, depression was associated with greater impairment on processing speed, executive (mental flexibility), and motor function (P's < 0.05). CONCLUSIONS: Depression contributes to NCI across a broad range of cognitive domains in HIV+ and HIV- individuals, but HIV+ depressed women show greater vulnerabilities in executive function. Treating depression may help to improve cognition in patients with HIV infection.
BACKGROUND:HIV-infected (HIV+) women seem to be more vulnerable to neurocognitive impairment (NCI) than HIV+ men, perhaps in part due to mental health factors. We assessed the association between elevated depressive symptoms and NCI among HIV+ and HIV-uninfected (HIV-) women and men. SETTING:Women's Interagency HIV Study and Multicenter AIDS Cohort Study. METHODS: Eight hundred fifty-eight HIV+ (429 women; 429 men) and 562 HIV- (281 women; 281 men) completed the Center for Epidemiologic Studies Depression (16 cutoff) Scale and measures of psychomotor speed/attention, executive, and motor function over multiple visits (or time points). Women's Interagency HIV Study and Multicenter AIDS Cohort Study participants were matched according to HIV status, age, race/ethnicity, and education. Generalized linear mixed models were used to examine interactions between biological sex, HIV serostatus, and depression on impairment (T-scores <40) after covariate adjustment. RESULTS: Despite a higher frequency of depression among men, the association between depression and executive function differed by sex and HIV serostatus. HIV+ women with depression had 5 times the odds of impairment on a measure of executive control and inhibition versus HIV- depressed women and 3 times the odds of impairment on that measure versus HIV+ depressedmen. Regardless of group status, depression was associated with greater impairment on processing speed, executive (mental flexibility), and motor function (P's < 0.05). CONCLUSIONS:Depression contributes to NCI across a broad range of cognitive domains in HIV+ and HIV- individuals, but HIV+ depressedwomen show greater vulnerabilities in executive function. Treating depression may help to improve cognition in patients with HIV infection.
Authors: Sara E Looby; Kathleen V Fitch; Suman Srinivasa; Janet Lo; Danielle Rafferty; Amanda Martin; Judith C Currier; Steven Grinspoon; Markella V Zanni Journal: AIDS Date: 2016-01-28 Impact factor: 4.177
Authors: Pauline M Maki; Leah H Rubin; Victor Valcour; Eileen Martin; Howard Crystal; Mary Young; Kathleen M Weber; Jennifer Manly; Jean Richardson; Christine Alden; Kathryn Anastos Journal: Neurology Date: 2014-12-24 Impact factor: 9.910
Authors: Joyce T Bromberger; Susan F Assmann; Nancy E Avis; Miriam Schocken; Howard M Kravitz; Adriana Cordal Journal: Am J Epidemiol Date: 2003-08-15 Impact factor: 4.897
Authors: Jyoti S Mathad; Nikhil Gupte; Ashwin Balagopal; David Asmuth; James Hakim; Breno Santos; Cynthia Riviere; Mina Hosseinipour; Patcharaphan Sugandhavesa; Rosa Infante; Sandy Pillay; Sandra W Cardoso; Noluthando Mwelase; Jyoti Pawar; Sima Berendes; Nagalingeswaran Kumarasamy; Bruno B Andrade; Thomas B Campbell; Judith S Currier; Susan E Cohn; Amita Gupta Journal: J Acquir Immune Defic Syndr Date: 2016-10-01 Impact factor: 3.731
Authors: Leah H Rubin; Scott A Langenecker; K Luan Phan; Sheila M Keating; Gretchen N Neigh; Kathleen M Weber; Pauline M Maki Journal: Psychoneuroendocrinology Date: 2020-02-07 Impact factor: 4.905
Authors: Alyssa C Vecchio; Dionna W Williams; Yanxun Xu; Danyang Yu; Deanna Saylor; Sarah Lofgren; Riley O'Toole; David R Boulware; Noeline Nakasujja; Gertrude Nakigozi; Alice Kisakye; James Batte; Richard Mayanja; Aggrey Anok; Steven J Reynolds; Thomas C Quinn; Ronald H Gray; Maria J Wawer; Ned Sacktor; Leah H Rubin Journal: Brain Behav Immun Date: 2020-12-24 Impact factor: 7.217
Authors: Jordan N Kohn; Matthew Shane Loop; Julie J Kim-Chang; Patricia A Garvie; John W Sleasman; Bernard Fischer; H Jonathon Rendina; Steven Paul Woods; Sharon L Nichols; Suzi Hong Journal: J Acquir Immune Defic Syndr Date: 2021-06-01 Impact factor: 3.771
Authors: Raha M Dastgheyb; Alison S Buchholz; Kathryn C Fitzgerald; Yanxun Xu; Dionna W Williams; Gayle Springer; Kathryn Anastos; Deborah R Gustafson; Amanda B Spence; Adaora A Adimora; Drenna Waldrop; David E Vance; Joel Milam; Hector Bolivar; Kathleen M Weber; Norman J Haughey; Pauline M Maki; Leah H Rubin Journal: Front Neurol Date: 2021-02-11 Impact factor: 4.003
Authors: Emily W Paolillo; Elizabeth C Pasipanodya; Raeanne C Moore; Brian W Pence; Joseph Hampton Atkinson; David J Grelotti; Igor Grant; Robert K Heaton; David J Moore Journal: J Acquir Immune Defic Syndr Date: 2020-07-01 Impact factor: 3.731
Authors: R C Basil; T T Brown; S Haberlen; L H Rubin; M Plankey; J T Becker; J E Lake; F J Palella; S Sarkar Journal: HIV Med Date: 2020-09-24 Impact factor: 3.180
Authors: Leah H Rubin; Erin E Sundermann; Raha Dastgheyb; Alison S Buchholz; Elizabeth Pasipanodya; Robert K Heaton; Igor Grant; Ronald Ellis; David J Moore Journal: Front Neurol Date: 2020-11-23 Impact factor: 4.086