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Literature DB >> 30890764

In vivo ways to unveil off-targets.

Guigen Zhang¹, Zhuo Zhou¹, Wensheng Wei².

Abstract

Mesh：

Substances：
Nucleotides
Cytosine

Year: 2019 PMID： 30890764 PMCID： PMC6796904 DOI： 10.1038/s41422-019-0159-2

Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617

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10 in total

1. Genome-wide target specificities of CRISPR RNA-guided programmable deaminases.

Authors: Daesik Kim; Kayeong Lim; Sang-Tae Kim; Sun-Heui Yoon; Kyoungmi Kim; Seuk-Min Ryu; Jin-Soo Kim
Journal: Nat Biotechnol Date: 2017-04-10 Impact factor: 54.908

2. Genome-wide target specificity of CRISPR RNA-guided adenine base editors.

Authors: Daesik Kim; Da-Eun Kim; Gyeorae Lee; Sung-Ik Cho; Jin-Soo Kim
Journal: Nat Biotechnol Date: 2019-03-04 Impact factor: 54.908

3. Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos.

Authors: Erwei Zuo; Yidi Sun; Wu Wei; Tanglong Yuan; Wenqin Ying; Hao Sun; Liyun Yuan; Lars M Steinmetz; Yixue Li; Hui Yang
Journal: Science Date: 2019-02-28 Impact factor: 47.728

4. Increased spontaneous mutation frequency in human cells expressing the phage PBS2-encoded inhibitor of uracil-DNA glycosylase.

Authors: E H Radany; K J Dornfeld; R J Sanderson; M K Savage; A Majumdar; M M Seidman; D W Mosbaugh
Journal: Mutat Res Date: 2000-09-15 Impact factor: 2.433

1 in total

Review 1. CRISPR/Cas Systems in Genome Editing: Methodologies and Tools for sgRNA Design, Off-Target Evaluation, and Strategies to Mitigate Off-Target Effects.

Authors: Hakim Manghwar; Bo Li; Xiao Ding; Amjad Hussain; Keith Lindsey; Xianlong Zhang; Shuangxia Jin
Journal: Adv Sci (Weinh) Date: 2020-02-06 Impact factor: 16.806

1 in total

In vivo ways to unveil off-targets.

1. Genome-wide target specificities of CRISPR RNA-guided programmable deaminases.

2. Genome-wide target specificity of CRISPR RNA-guided adenine base editors.

3. Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos.

4. Increased spontaneous mutation frequency in human cells expressing the phage PBS2-encoded inhibitor of uracil-DNA glycosylase.

5. Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells.

6. Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems.

7. APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages.

8. Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage.

9. Genome-wide profiling of adenine base editor specificity by EndoV-seq.

10. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage.

Review 1. CRISPR/Cas Systems in Genome Editing: Methodologies and Tools for sgRNA Design, Off-Target Evaluation, and Strategies to Mitigate Off-Target Effects.