Max-Joseph Grimm1,2, Gesine Respondek1,2, Maria Stamelou3, Thomas Arzberger2,4,5, Leslie Ferguson6, Ellen Gelpi7,8, Armin Giese4, Murray Grossman9, David J Irwin9, Alexander Pantelyat10, Alex Rajput6, Sigrun Roeber4, John C van Swieten11, Claire Troakes12, Angelo Antonini13, Kailash P Bhatia14, Carlo Colosimo15, Thilo van Eimeren16, Jan Kassubek17, Johannes Levin2,18, Wassilios G Meissner19,20,21, Christer Nilsson22, Wolfgang H Oertel23, Ines Piot1,2, Werner Poewe24, Gregor K Wenning24, Adam Boxer25, Lawrence I Golbe26, Keith A Josephs27, Irene Litvan28, Huw R Morris29, Jennifer L Whitwell30, Yaroslau Compta31, Jean-Christophe Corvol32, Anthony E Lang33, James B Rowe34, Günter U Höglinger1,2. 1. Department of Neurology, Technische Universität München, Munich, Germany. 2. German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. 3. Second Department of Neurology, Attikon University Hospital, University of Athens, Athens, Greece. 4. Center for Neuropathology and Prion Research, Ludwig-Maximilians-Universität, Munich, Germany. 5. Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany. 6. Division of Neurology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. 7. Neurological Tissue Bank and Neurology Department, Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CERCA, Barcelona, Catalonia, Spain. 8. Institute of Neurology, Medical University of Vienna, Vienna, Austria. 9. Frontotemporal Degeneration Center, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 10. Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA. 11. Department of Neurology, Erasmus Medical Centre, Rotterdam, The Netherlands. 12. London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK. 13. Parkinson and Movement Disorders Unit, IRCCS Hospital San Camillo, Venice, and Department of Neurosciences, Padova University, Padova, Italy. 14. Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, UK. 15. Department of Neurology, Santa Maria University Hospital of Terni, Terni, Italy. 16. Departments of Nuclear Medicine and Neurology, University of Cologne, Cologne, Germany. 17. Department of Neurology, University of Ulm, Ulm, Germany. 18. Department of Neurology, Ludwig-Maximilians-Universität, Munich, Germany. 19. Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France. 20. Service de Neurologie, Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France. 21. Dept. Medicine, University of Otago, Christchurch, and New Zealand Brain Research Institute, Christchurch, New Zealand. 22. Department of Clinical Sciences, Division of Neurology, Lund University, Lund, Sweden. 23. Department of Neurology, Philipps Universität, Marburg, Germany. 24. Department of Neurology, Medical University Innsbruck, Innsbruck, Austria. 25. Memory and Aging Center, Department of Neurology, University of California, San Francisco, California, USA. 26. Department of Neurology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA. 27. Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA. 28. Department of Neurology, University of California, San Diego, California, USA. 29. Department of Clinical Neuroscience, UCL Institute of Neurology, Queen Square, London, UK. 30. Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA. 31. Parkinson's Disease & Movement Disorders Unit, Hospital Clínic/IDIBAPS/CIBERNED/European Reference Network for Rare Neurological Diseases (ERN-RND)/Institut de Neurociències, Universitat de Barcelona, Barcelona, Catalonia, Spain. 32. Sorbonne Université, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, ICM, Hôpital Pitié-Salpêtrière, Department of Neurology, Paris, France. 33. The Edmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Ontario, Canada. 34. Department of Clinical Neurosciences and Cambridge Centre for Parkinson-Plus, Cambridge University, Cambridge, UK.
Abstract
BACKGROUND: The Movement Disorder Society criteria for progressive supranuclear palsy define diagnostic allocations, stratified by certainty levels and clinical predominance types. We aimed to study the frequency of ambiguous multiple allocations and to develop rules to eliminate them. METHODS: We retrospectively collected standardized clinical data by chart review in a multicenter cohort of autopsy-confirmed patients with progressive supranuclear palsy, to classify them by diagnostic certainty level and predominance type and to identify multiple allocations. RESULTS: Comprehensive data were available from 195 patients. More than one diagnostic allocation occurred in 157 patients (80.5%). On average, 5.4 allocations were possible per patient. We developed four rules for Multiple Allocations eXtinction (MAX). They reduced the number of patients with multiple allocations to 22 (11.3%), and the allocations per patient to 1.1. CONCLUSIONS: The proposed MAX rules help to standardize the application of the Movement Disorder Society criteria for progressive supranuclear palsy.
BACKGROUND: The Movement Disorder Society criteria for progressive supranuclear palsy define diagnostic allocations, stratified by certainty levels and clinical predominance types. We aimed to study the frequency of ambiguous multiple allocations and to develop rules to eliminate them. METHODS: We retrospectively collected standardized clinical data by chart review in a multicenter cohort of autopsy-confirmed patients with progressive supranuclear palsy, to classify them by diagnostic certainty level and predominance type and to identify multiple allocations. RESULTS: Comprehensive data were available from 195 patients. More than one diagnostic allocation occurred in 157 patients (80.5%). On average, 5.4 allocations were possible per patient. We developed four rules for Multiple Allocations eXtinction (MAX). They reduced the number of patients with multiple allocations to 22 (11.3%), and the allocations per patient to 1.1. CONCLUSIONS: The proposed MAX rules help to standardize the application of the Movement Disorder Society criteria for progressive supranuclear palsy.
Authors: Farwa Ali; Peter R Martin; Hugo Botha; J Eric Ahlskog; James H Bower; Joseph Y Masumoto; Demetrius Maraganore; Anhar Hassan; Scott Eggers; Bradley F Boeve; David S Knopman; Daniel Drubach; Ronald C Petersen; Erika Driver Dunkley; Jay van Gerpen; Ryan Uitti; Jennifer L Whitwell; Dennis W Dickson; Keith A Josephs Journal: Mov Disord Date: 2019-02-06 Impact factor: 10.338
Authors: Gesine Respondek; Carolin Kurz; Thomas Arzberger; Yaroslau Compta; Elisabet Englund; Leslie W Ferguson; Ellen Gelpi; Armin Giese; David J Irwin; Wassilios G Meissner; Christer Nilsson; Alexander Pantelyat; Alex Rajput; John C van Swieten; Claire Troakes; Keith A Josephs; Anthony E Lang; Brit Mollenhauer; Ulrich Müller; Jennifer L Whitwell; Angelo Antonini; Kailash P Bhatia; Yvette Bordelon; Jean-Christophe Corvol; Carlo Colosimo; Richard Dodel; Murray Grossman; Jan Kassubek; Florian Krismer; Johannes Levin; Stefan Lorenzl; Huw Morris; Peter Nestor; Wolfgang H Oertel; Gil D Rabinovici; James B Rowe; Thilo van Eimeren; Gregor K Wenning; Adam Boxer; Lawrence I Golbe; Irene Litvan; Maria Stamelou; Günter U Höglinger Journal: Mov Disord Date: 2017-05-13 Impact factor: 10.338
Authors: Jennifer L Whitwell; Günter U Höglinger; Angelo Antonini; Yvette Bordelon; Adam L Boxer; Carlo Colosimo; Thilo van Eimeren; Lawrence I Golbe; Jan Kassubek; Carolin Kurz; Irene Litvan; Alexander Pantelyat; Gil Rabinovici; Gesine Respondek; Axel Rominger; James B Rowe; Maria Stamelou; Keith A Josephs Journal: Mov Disord Date: 2017-05-13 Impact factor: 10.338
Authors: Günter U Höglinger; Gesine Respondek; Maria Stamelou; Carolin Kurz; Keith A Josephs; Anthony E Lang; Brit Mollenhauer; Ulrich Müller; Christer Nilsson; Jennifer L Whitwell; Thomas Arzberger; Elisabet Englund; Ellen Gelpi; Armin Giese; David J Irwin; Wassilios G Meissner; Alexander Pantelyat; Alex Rajput; John C van Swieten; Claire Troakes; Angelo Antonini; Kailash P Bhatia; Yvette Bordelon; Yaroslau Compta; Jean-Christophe Corvol; Carlo Colosimo; Dennis W Dickson; Richard Dodel; Leslie Ferguson; Murray Grossman; Jan Kassubek; Florian Krismer; Johannes Levin; Stefan Lorenzl; Huw R Morris; Peter Nestor; Wolfgang H Oertel; Werner Poewe; Gil Rabinovici; James B Rowe; Gerard D Schellenberg; Klaus Seppi; Thilo van Eimeren; Gregor K Wenning; Adam L Boxer; Lawrence I Golbe; Irene Litvan Journal: Mov Disord Date: 2017-05-03 Impact factor: 10.338
Authors: Gesine Respondek; Maria Stamelou; Carolin Kurz; Leslie W Ferguson; Alexander Rajput; Wan Zheng Chiu; John C van Swieten; Claire Troakes; Safa Al Sarraj; Ellen Gelpi; Carles Gaig; Eduardo Tolosa; Wolfgang H Oertel; Armin Giese; Sigrun Roeber; Thomas Arzberger; Stefan Wagenpfeil; Günter U Höglinger Journal: Mov Disord Date: 2014-11-05 Impact factor: 10.338
Authors: Gesine Respondek; Max-Joseph Grimm; Ines Piot; Thomas Arzberger; Yaroslau Compta; Elisabet Englund; Leslie W Ferguson; Ellen Gelpi; Sigrun Roeber; Armin Giese; Murray Grossman; David J Irwin; Wassilios G Meissner; Christer Nilsson; Alexander Pantelyat; Alex Rajput; John C van Swieten; Claire Troakes; Günter U Höglinger Journal: Mov Disord Date: 2019-09-30 Impact factor: 10.338
Authors: Sarah M Bower; Stephen D Weigand; Farwa Ali; Heather M Clark; Hugo Botha; Julie A Stierwalt; Jennifer L Whitwell; Keith A Josephs Journal: Mov Disord Clin Pract Date: 2021-12-31
Authors: Zeynep Idil Seckin; Joseph R Duffy; Edythe A Strand; Heather M Clark; Rene L Utianski; Mary M Machulda; Hugo Botha; Farwa Ali; Nha Trang Thu Pham; Val J Lowe; Jennifer L Whitwell; Keith A Josephs Journal: Parkinsonism Relat Disord Date: 2020-10-07 Impact factor: 4.891
Authors: Ali Shoeibi; Irene Litvan; Jorge L Juncos; Yvette Bordelon; David Riley; David Standaert; Stephen G Reich; David Shprecher; Deborah Hall; Connie Marras; Benzi Kluger; Nahid Olfati; Joseph Jankovic Journal: Parkinsonism Relat Disord Date: 2019-10-14 Impact factor: 4.891
Authors: Jennifer L Whitwell; Chase A Stevens; Joseph R Duffy; Heather M Clark; Mary M Machulda; Edythe A Strand; Peter R Martin; Rene L Utianski; Hugo Botha; Anthony J Spychalla; Matthew L Senjem; Christopher G Schwarz; Clifford R Jack; Farwa Ali; Anhar Hassan; Keith A Josephs Journal: Mov Disord Clin Pract Date: 2019-05-29
Authors: Maria Stamelou; Gesine Respondek; Nikolaos Giagkou; Jennifer L Whitwell; Gabor G Kovacs; Günter U Höglinger Journal: Nat Rev Neurol Date: 2021-08-23 Impact factor: 42.937