BACKGROUND: Apathy and depression commonly occur in patients with progressive supranuclear palsy (PSP)-Richardson's syndrome variant; depression often requiring treatment. Little is known, however, about apathy and depression among other PSP variants. METHODS: We prospectively studied 97 newly diagnosed PSP patients. All were classified into a PSP variant using the 2017 Movement Disorder Society-PSP criteria and administered the Geriatric Depression and Apathy Evaluation Scales. Differences in apathy and depression frequency and severity across six variants, and secondarily across PSP-Richardson's syndrome, PSP-Cortical and PSP-Subcortical, were analyzed using ANCOVA and linear regression adjusting for disease severity. RESULTS: Depression (55%) was more common than apathy (12%). PSP-Speech/Language (PSP-SL) variant had the lowest depression frequency (13%) and lower depression scores than the other variants. No differences in apathy frequency/severity were identified. CONCLUSION: PSP-SL patients may have less depression compared to PSP-Richardson's syndrome and other PSP variants.
BACKGROUND: Apathy and depression commonly occur in patients with progressive supranuclear palsy (PSP)-Richardson's syndrome variant; depression often requiring treatment. Little is known, however, about apathy and depression among other PSP variants. METHODS: We prospectively studied 97 newly diagnosed PSP patients. All were classified into a PSP variant using the 2017 Movement Disorder Society-PSP criteria and administered the Geriatric Depression and Apathy Evaluation Scales. Differences in apathy and depression frequency and severity across six variants, and secondarily across PSP-Richardson's syndrome, PSP-Cortical and PSP-Subcortical, were analyzed using ANCOVA and linear regression adjusting for disease severity. RESULTS: Depression (55%) was more common than apathy (12%). PSP-Speech/Language (PSP-SL) variant had the lowest depression frequency (13%) and lower depression scores than the other variants. No differences in apathy frequency/severity were identified. CONCLUSION: PSP-SL patients may have less depression compared to PSP-Richardson's syndrome and other PSP variants.
Authors: Farwa Ali; Peter R Martin; Hugo Botha; J Eric Ahlskog; James H Bower; Joseph Y Masumoto; Demetrius Maraganore; Anhar Hassan; Scott Eggers; Bradley F Boeve; David S Knopman; Daniel Drubach; Ronald C Petersen; Erika Driver Dunkley; Jay van Gerpen; Ryan Uitti; Jennifer L Whitwell; Dennis W Dickson; Keith A Josephs Journal: Mov Disord Date: 2019-02-06 Impact factor: 10.338
Authors: Gesine Respondek; Max-Joseph Grimm; Ines Piot; Thomas Arzberger; Yaroslau Compta; Elisabet Englund; Leslie W Ferguson; Ellen Gelpi; Sigrun Roeber; Armin Giese; Murray Grossman; David J Irwin; Wassilios G Meissner; Christer Nilsson; Alexander Pantelyat; Alex Rajput; John C van Swieten; Claire Troakes; Günter U Höglinger Journal: Mov Disord Date: 2019-09-30 Impact factor: 10.338
Authors: John C Morgan; Xiaolan Ye; Jennifer A Mellor; Keisha J Golden; Jorge Zamudio; Louis A Chiodo; Yanjun Bao; Tao Xie Journal: J Neurol Sci Date: 2020-12-25 Impact factor: 3.181
Authors: Keith A Josephs; Jennifer L Whitwell; Scott D Eggers; Matthew L Senjem; Clifford R Jack Journal: Mov Disord Date: 2011-01-12 Impact factor: 10.338