Literature DB >> 3087751

Benzo(a)pyrene hydroxylase activity in human bronchial mucus.

A Kapoor, J K Batra, U K Luthra, R C Jain, T A Venkitasubramanian, H G Raj.   

Abstract

Sputum collected from patients with respiratory diseases were examined for presence of benzo(a)pyrene hydroxylase (BPH) activity. The human bronchial mucus used in these studies had significant capability to metabolize benzo(a)pyrene. Clarification of the sputum by agents such as N-acetylcysteine or pancreatin in presence of antibiotics was found to be essential for the detection of BPH activity. In vitro incubation of the clarified human bronchial mucus with benzoflavone caused inhibition, while 7,8-dimethyl-benzanthracene induced BPH enzyme activity.

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Year:  1986        PMID： 3087751     DOI： 10.1007/BF03189773

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  16 in total

1.  A reliable, sensitive, and convenient radioactive assay for benzpyrene monooxygenase.

Authors:  J W DePierre; M S Moron; K A Johannesen; L Ernster
Journal:  Anal Biochem       Date:  1975-02       Impact factor: 3.365

2.  The role of disulfide bonds in maintaining the gel structure of bronchial mucus.

Authors:  G P Roberts
Journal:  Arch Biochem Biophys       Date:  1976-04       Impact factor: 4.013

Review 3.  Chemical aspects of respiratory mucus.

Authors:  G P Roberts
Journal:  Br Med Bull       Date:  1978-01       Impact factor: 4.291

4.  Aryl hydrocarbon (benzopyrene) hydroxylase is stimulated in human lymphocytes by mitogens and benz(a)anthracene.

Authors:  J P Whitlock; H L Cooper; V H Gelboin
Journal:  Science       Date:  1972-08-18       Impact factor: 47.728

5.  Metabolism of drugs and carcinogens by human liver enzymes.

Authors:  R Kuntzman; L C Mark; L C Brand; B M Jacobson; W Levin; A H Conney
Journal:  J Pharmacol Exp Ther       Date:  1966-04       Impact factor: 4.030

6.  Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma.

Authors:  G Kellermann; C R Shaw; M Luyten-Kellerman
Journal:  N Engl J Med       Date:  1973-11-01       Impact factor: 91.245

Review 7.  Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse.

Authors:  D W Nebert; J R Robinson; A Niwa; K Kumaki; A P Poland
Journal:  J Cell Physiol       Date:  1975-04       Impact factor: 6.384

8.  Value of sputum cytology in the differential diagnosis of alveolar cell carcinoma from bronchogenic adenocarcinoma.

Authors:  R K Gupta
Journal:  Acta Cytol       Date:  1981 May-Jun       Impact factor: 2.319

9.  The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states.

Authors:  D W Nebert; H V Gelboin
Journal:  Arch Biochem Biophys       Date:  1969-10       Impact factor: 4.013

10.  Induction of aryl hydrocarbon hydroxylase in human pulmonary alveolar macrophages by cigarette smoking.

Authors:  E T Cantrell; G A Warr; D L Busbee; R R Martin
Journal:  J Clin Invest       Date:  1973-08       Impact factor: 14.808
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