Literature DB >> 30877487

Factors associated with willingness to provide biospecimens for genetics research among African American cancer survivors.

Altovise T Ewing1, Nnenna Kalu2, Gloria Cain2, Lori H Erby3, Luisel J Ricks-Santi4, Eva Tetteyfio-Kidd Telemaque5, Denise M Scott2.   

Abstract

This study evaluated factors associated with willingness to provide biospecimens for cancer genetic research among African American cancer survivors. A total of 200 African American adults diagnosed with breast, colon, and/or prostate cancers completed a self-administered survey. Family history information, beliefs about cancer research, cancer genetics and disparities knowledge, willingness to provide a biospecimen, and demographics were obtained. Chi-square, independent samples t tests, and logistic regression analyses were performed. Overall, 79% of this sample was willing to provide a biospecimen for cancer genetics research. Independent associations of willingness to provide a biospecimen existed among demographics (males (p = 0.041)), those who believed in the importance of genetic causes of cancer (p < 0.001), individuals who believe it is important to participate in genetics research (p < 0.001), and those who indicated they would participate in genetics research to help future generations (p = 0.026). Overall, 12.5-56% of participants demonstrated some level of genetics and cancer disparities. This study identified factors that may be incorporated into future research interventions to engage the African American cancer population in cancer genetics biobanking research.

Entities:  

Keywords:  African American cancer survivors; Biospecimens; Cancer genetics research; Cancer health disparities; Willingness to participate

Year:  2019        PMID: 30877487      PMCID: PMC6754482          DOI: 10.1007/s12687-019-00411-0

Source DB:  PubMed          Journal:  J Community Genet        ISSN: 1868-310X


  52 in total

1.  The emergence of biobanks: practical design considerations for large population-based studies of gene-environment interactions.

Authors:  Robert L Davis; Muin J Khoury
Journal:  Community Genet       Date:  2007

2.  A new initiative on precision medicine.

Authors:  Francis S Collins; Harold Varmus
Journal:  N Engl J Med       Date:  2015-01-30       Impact factor: 91.245

3.  Knowledge about genetic risk for breast cancer and perceptions of genetic testing in a sociodemographically diverse sample.

Authors:  K A Donovan; D C Tucker
Journal:  J Behav Med       Date:  2000-02

4.  Racial and ethnic differences in willingness to participate in psychiatric genetic research.

Authors:  Eleanor J Murphy; Priya Wickramaratne; Myrna M Weissman
Journal:  Psychiatr Genet       Date:  2009-08       Impact factor: 2.458

5.  Understanding participation by African Americans in cancer genetics research.

Authors:  Jasmine A McDonald; Frances K Barg; Benita Weathers; Carmen E Guerra; Andrea B Troxel; Susan Domchek; Deborah Bowen; Judy A Shea; Chanita Hughes Halbert
Journal:  J Natl Med Assoc       Date:  2012 Jul-Aug       Impact factor: 1.798

6.  Colorectal cancer knowledge, perceptions, and behaviors in African Americans.

Authors:  Pauline M Green; Beatrice Adderley Kelly
Journal:  Cancer Nurs       Date:  2004 May-Jun       Impact factor: 2.592

7.  Asking the right questions: views on genetic variation research among black and white research participants.

Authors:  Jada Bussey-Jones; Gail Henderson; Joanne Garrett; Mairead Moloney; Connie Blumenthal; Giselle Corbie-Smith
Journal:  J Gen Intern Med       Date:  2008-12-20       Impact factor: 5.128

8.  A collaborative study of the etiology of breast cancer subtypes in African American women: the AMBER consortium.

Authors:  Julie R Palmer; Christine B Ambrosone; Andrew F Olshan
Journal:  Cancer Causes Control       Date:  2013-12-17       Impact factor: 2.506

9.  Low rates of acceptance of BRCA1 and BRCA2 test results among African American women at increased risk for hereditary breast-ovarian cancer.

Authors:  Chanita Hughes Halbert; Lisa Kessler; Jill E Stopfer; Susan Domchek; E Paul Wileyto
Journal:  Genet Med       Date:  2006-09       Impact factor: 8.822

Review 10.  Biobanks in the era of personalized medicine: objectives, challenges, and innovation: Overview.

Authors:  Judita Kinkorová
Journal:  EPMA J       Date:  2016-02-22       Impact factor: 6.543

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