Prabha H Andraweera1, Zohra S Lassi2. 1. Adelaide Medical School and The Robinson Research Institute, The University of Adelaide, Adelaide, Australia. Electronic address: prabha.andraweera@adelaide.edu.au. 2. Adelaide Medical School and The Robinson Research Institute, The University of Adelaide, Adelaide, Australia.
Abstract
OBJECTIVE: To evaluate evidence for increased cardiovascular disease (CVD) risk factors in children exposed to preeclampsia in utero. STUDY DESIGN: PubMed, the Cumulative Index to Nursing and Allied Health Literature, the Cochrane Library, and EMBASE electronic databases were searched with an end of search date of June 4, 2018. Prospective and retrospective studies that compared CVD risk factors in those exposed to preeclampsia in utero with controls were eligible. Information was extracted on established CVD risk factors, including blood pressure, lipid profile, blood glucose, fasting insulin, body mass index, and endothelial/microvascular function. RESULTS: Thirty-six studies provided cumulated data on 53 029 individuals. In utero exposure to preeclampsia was associated with 5.17 mm Hg (95% CI 1.60-8.73) greater mean systolic, 4.06 mm Hg (95% CI 0.67-7.44) greater mean diastolic blood pressure, and 0.36 kg/m2 (95% CI 0.04-0.68) greater mean body mass index during childhood or young adulthood. No significant association was seen between exposure to preeclampsia in utero and other CVD risk factors. CONCLUSIONS: Offspring of preeclamptic pregnancies demonstrate risk factors for CVD during childhood and young adult life. Early blood pressure screening of children born after preeclamptic pregnancies may identify those that require interventions or preventive strategies to reduce later life CVD risk.
OBJECTIVE: To evaluate evidence for increased cardiovascular disease (CVD) risk factors in children exposed to preeclampsia in utero. STUDY DESIGN: PubMed, the Cumulative Index to Nursing and Allied Health Literature, the Cochrane Library, and EMBASE electronic databases were searched with an end of search date of June 4, 2018. Prospective and retrospective studies that compared CVD risk factors in those exposed to preeclampsia in utero with controls were eligible. Information was extracted on established CVD risk factors, including blood pressure, lipid profile, blood glucose, fasting insulin, body mass index, and endothelial/microvascular function. RESULTS: Thirty-six studies provided cumulated data on 53 029 individuals. In utero exposure to preeclampsia was associated with 5.17 mm Hg (95% CI 1.60-8.73) greater mean systolic, 4.06 mm Hg (95% CI 0.67-7.44) greater mean diastolic blood pressure, and 0.36 kg/m2 (95% CI 0.04-0.68) greater mean body mass index during childhood or young adulthood. No significant association was seen between exposure to preeclampsia in utero and other CVD risk factors. CONCLUSIONS: Offspring of preeclamptic pregnancies demonstrate risk factors for CVD during childhood and young adult life. Early blood pressure screening of children born after preeclamptic pregnancies may identify those that require interventions or preventive strategies to reduce later life CVD risk.
Authors: Laura E Coats; Gwendolyn K Davis; Ashley D Newsome; Norma B Ojeda; Barbara T Alexander Journal: Curr Hypertens Rep Date: 2019-06-21 Impact factor: 5.369
Authors: Priya M Freaney; Katharine Harrington; Rebecca Molsberry; Amanda M Perak; Michael C Wang; William Grobman; Philip Greenland; Norrina B Allen; Simon Capewell; Martin O'Flaherty; Donald M Lloyd-Jones; Sadiya S Khan Journal: J Am Heart Assoc Date: 2022-05-18 Impact factor: 6.106
Authors: Vesna D Garovic; Ralf Dechend; Thomas Easterling; S Ananth Karumanchi; Suzanne McMurtry Baird; Laura A Magee; Sarosh Rana; Jane V Vermunt; Phyllis August Journal: Hypertension Date: 2021-12-15 Impact factor: 9.897
Authors: Amanda M Perak; Nicola Lancki; Alan Kuang; Darwin R Labarthe; Norrina B Allen; Svati H Shah; Lynn P Lowe; William A Grobman; Jean M Lawrence; Donald M Lloyd-Jones; William L Lowe; Denise M Scholtens Journal: JAMA Date: 2021-02-16 Impact factor: 56.272
Authors: Camilo Espinosa; Martin Becker; Ivana Marić; Ronald J Wong; Gary M Shaw; Brice Gaudilliere; Nima Aghaeepour; David K Stevenson Journal: Trends Mol Med Date: 2021-02-08 Impact factor: 15.272
Authors: Jennifer R Meeks; Arvind B Bambhroliya; Katie M Alex; Sunil A Sheth; Sean I Savitz; Eliza C Miller; Louise D McCullough; Farhaan S Vahidy Journal: JAMA Netw Open Date: 2020-04-01