Kyouhei Akisato1, Reisuke Nishihara2, Hajime Okazaki2, Takanori Masuda3, Ayako Hironobe2, Hiromi Ishizaki2, Kondo Shota2, Hiroshi Yamaguchi1, Yoshinori Funama4. 1. Department of Radiology, JA Hiroshima General Hospital, Hatsukaichi-shi, Hiroshima, Japan. 2. Department of Diagnostic Imaging, JA Hiroshima General Hospital, Hatsukaichi-shi, Hiroshima, Japan. 3. Department of Radiological Technology, Tsuchiya General Hospital, 3-30 Nakajima-cho, Naka-ku, Hiroshima 730-8655, Japan. Electronic address: takanorimasuda@yahoo.co.jp. 4. Department of Medical Physics, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Abstract
RATIONALE AND OBJECTIVES: This study investigated detecting bone marrow edema (BME) in patients with vertebral compression fractures. We compared dual-energy material density analysis images to magnetic resonance imaging (MRI), which is considered the gold standard. MATERIALS AND METHODS: In this retrospective study, 260 vertebral bodies from 30 patients (11 males, 19 females, mean age of 81) were assessed by MRI and dual-energy material density analysis. Diagnostic accuracy was assessed using the receiver operating characteristic (ROC) curve. Fifty-two of the 260 vertebral bodies were considered to have BME based on the dual-energy material density analysis images; 50 were deemed to have BME by MRI. RESULTS: ROC analysis of the dual-energy material density analysis values revealed an area under the ROC curve of 0.95 for radiologist 1, 0.97 for radiologist 2, and 0.96 for radiologist 3. A mean cutoff value of 1032.6 mg/cm3 provided an overall sensitivity of 93.0% (95% confidence intervals [CI]: 86.0%-99.9%), specificity of 98.0% (95% CI: 95.5%-99.0%), accuracy of 97.0% (95% CI: 95.2%-99.0%), positive predictive value of 95.0% (95% CI: 81.0%-97.5%), and negative predictive value of 98.0% (95% CI: 93.0%-99.9%). CONCLUSION: BME in patients with vertebral compression fractures can be detected using dual-energy material density analysis images.
RATIONALE AND OBJECTIVES: This study investigated detecting bone marrow edema (BME) in patients with vertebral compression fractures. We compared dual-energy material density analysis images to magnetic resonance imaging (MRI), which is considered the gold standard. MATERIALS AND METHODS: In this retrospective study, 260 vertebral bodies from 30 patients (11 males, 19 females, mean age of 81) were assessed by MRI and dual-energy material density analysis. Diagnostic accuracy was assessed using the receiver operating characteristic (ROC) curve. Fifty-two of the 260 vertebral bodies were considered to have BME based on the dual-energy material density analysis images; 50 were deemed to have BME by MRI. RESULTS: ROC analysis of the dual-energy material density analysis values revealed an area under the ROC curve of 0.95 for radiologist 1, 0.97 for radiologist 2, and 0.96 for radiologist 3. A mean cutoff value of 1032.6 mg/cm3 provided an overall sensitivity of 93.0% (95% confidence intervals [CI]: 86.0%-99.9%), specificity of 98.0% (95% CI: 95.5%-99.0%), accuracy of 97.0% (95% CI: 95.2%-99.0%), positive predictive value of 95.0% (95% CI: 81.0%-97.5%), and negative predictive value of 98.0% (95% CI: 93.0%-99.9%). CONCLUSION: BME in patients with vertebral compression fractures can be detected using dual-energy material density analysis images.
Authors: Tommaso D'Angelo; Moritz H Albrecht; Danilo Caudo; Silvio Mazziotti; Thomas J Vogl; Julian L Wichmann; Simon Martin; Ibrahim Yel; Giorgio Ascenti; Vitali Koch; Giuseppe Cicero; Alfredo Blandino; Christian Booz Journal: Eur Radiol Exp Date: 2021-09-03
Authors: Marco Cavallaro; Tommaso D'Angelo; Moritz H Albrecht; Ibrahim Yel; Simon S Martin; Julian L Wichmann; Lukas Lenga; Silvio Mazziotti; Alfredo Blandino; Giorgio Ascenti; Marcello Longo; Thomas J Vogl; Christian Booz Journal: Eur Radiol Date: 2021-07-02 Impact factor: 5.315