Orestis Lyros1, Yusef Moulla1, Matthias Mehdorn1, Katrin Schierle2, Robert Sucher1, Arne Dietrich3,4,5. 1. Division of Bariatric Surgery, Clinic of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital, Liebigstrasse. 20, D-4015, Leipzig, Germany. 2. Institute of Pathology, University Hospital Leipzig, Leipzig, Germany. 3. Division of Bariatric Surgery, Clinic of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital, Liebigstrasse. 20, D-4015, Leipzig, Germany. arne.dietrich@medizin.uni-leipzig.de. 4. Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig, Germany. arne.dietrich@medizin.uni-leipzig.de. 5. Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital, Liebigstr. 20, D-04103, Leipzig, Germany. arne.dietrich@medizin.uni-leipzig.de.
Abstract
INTRODUCTION: Intraoperative pathologic findings during bariatric surgery are relatively rare. Gastrointestinal stromal tumors (GISTs) are commonly located in the stomach and account for < 1% of all neoplasms of the alimentary tract. Coincidental detection of GISTs during bariatric surgery has been reported around 0.8%. We analyzed the incidence of GISTs in bariatric patients and investigated whether simultaneous resection can be oncologically adequate. MATERIAL/ METHODS: A single-center retrospective study of 707 morbidly obese patients, who underwent bariatric surgery (either Roux-en-Y gastric bypass (RYGB), One Anastomosis Gastric Bypass (OAGB), or sleeve resection (LSG) between January 2012 and August 2018). Intraoperative incidental GISTs were recorded and documented for tumor size, localization, immunoreactivity, and mitotic index. RESULTS: Nine (1.27%) patients were identified with GISTs. Seven (78%) tumors were detected in women; mean age 55.6 (range 27-74), mean BMI 51.7 mg/m2 (range 38-71). GISTs were predominantly located in the stomach (78%) and two (22%) within the small bowel; six were found during RYGB vs. three during LSG. No abort of surgery or change of the intended procedure was necessary. All tumors (0.2-3.7 cm) were resected with disease-free surgical margins and displayed low malignancy. No adjuvant therapy was necessary. CONCLUSIONS: The incidence of incidental GISTs in our series was higher to what has already been reported. Risk of malignancy was low and resection as part of the bariatric procedure was considered as definitive treatment. Suspicious tumors should be removed and confirmed by histology. In case of GIST histology, tumor resection with negative margins may be weighed as complete oncological treatment if there is low risk of malignancy.
INTRODUCTION: Intraoperative pathologic findings during bariatric surgery are relatively rare. Gastrointestinal stromal tumors (GISTs) are commonly located in the stomach and account for < 1% of all neoplasms of the alimentary tract. Coincidental detection of GISTs during bariatric surgery has been reported around 0.8%. We analyzed the incidence of GISTs in bariatric patients and investigated whether simultaneous resection can be oncologically adequate. MATERIAL/ METHODS: A single-center retrospective study of 707 morbidly obesepatients, who underwent bariatric surgery (either Roux-en-Y gastric bypass (RYGB), One Anastomosis Gastric Bypass (OAGB), or sleeve resection (LSG) between January 2012 and August 2018). Intraoperative incidental GISTs were recorded and documented for tumor size, localization, immunoreactivity, and mitotic index. RESULTS: Nine (1.27%) patients were identified with GISTs. Seven (78%) tumors were detected in women; mean age 55.6 (range 27-74), mean BMI 51.7 mg/m2 (range 38-71). GISTs were predominantly located in the stomach (78%) and two (22%) within the small bowel; six were found during RYGB vs. three during LSG. No abort of surgery or change of the intended procedure was necessary. All tumors (0.2-3.7 cm) were resected with disease-free surgical margins and displayed low malignancy. No adjuvant therapy was necessary. CONCLUSIONS: The incidence of incidental GISTs in our series was higher to what has already been reported. Risk of malignancy was low and resection as part of the bariatric procedure was considered as definitive treatment. Suspicious tumors should be removed and confirmed by histology. In case of GIST histology, tumor resection with negative margins may be weighed as complete oncological treatment if there is low risk of malignancy.
Authors: Zachary E Stiles; Tyler M Rist; Paxton V Dickson; Evan S Glazer; Martin D Fleming; David Shibata; Jeremiah L Deneve Journal: J Surg Res Date: 2017-05-10 Impact factor: 2.192
Authors: Kjetil Søreide; Oddvar M Sandvik; Jon Arne Søreide; Vanja Giljaca; Andrea Jureckova; V Ramesh Bulusu Journal: Cancer Epidemiol Date: 2015-11-24 Impact factor: 2.984
Authors: Marinos C Makris; Andreas Alexandrou; Efstathios G Papatsoutsos; George Malietzis; Diamantis I Tsilimigras; Alfredo D Guerron; Demetrios Moris Journal: In Vivo Date: 2017 Nov-Dec Impact factor: 2.155