Literature DB >> 29102924

Ghrelin and Obesity: Identifying Gaps and Dispelling Myths. A Reappraisal.

Marinos C Makris1,2, Andreas Alexandrou3, Efstathios G Papatsoutsos4, George Malietzis5, Diamantis I Tsilimigras3, Alfredo D Guerron6, Demetrios Moris7.   

Abstract

The etiology of obesity is complex. Environmental and genetic causes have been implicated in the development of this disease. Ghrelin is a hormone known to stimulate appetite. There are numerous possible actions through which ghrelin exerts its effect in the body: a) Overproduction of ghrelin, b) reduced ghrelin following meals, and c) increased receptor sensitivity to ghrelin action. Sleeve gastrectomy, a bariatric procedure, leads to reduction of ghrelin levels and subsequently to weight loss. However, there are many limitations to measurement of the fasting plasma level of the active form of ghrelin. The establishment of the exact correlation between ghrelin, appetite and obesity could be vital for the fight against obesity. Copyright
© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Entities:  

Keywords:  Ghrelin; appetite; bariatric surgery; diet; hormone levels; obesity; review

Mesh：

Substances：

Year:  2017        PMID： 29102924      PMCID： PMC5756630          DOI： 10.21873/invivo.11168

Source DB:  PubMed          Journal:  In Vivo        ISSN： 0258-851X            Impact factor:   2.155


  27 in total

1.  Prospective controlled study of effect of laparoscopic sleeve gastrectomy on small bowel transit time and gastric emptying half-time in morbidly obese patients with type 2 diabetes mellitus.

Authors:  Shashank Shah; Poonam Shah; Jayashree Todkar; Michel Gagner; S Sonar; S Solav
Journal:  Surg Obes Relat Dis       Date:  2009-12-22       Impact factor: 4.734

2.  The disease burden associated with overweight and obesity.

Authors:  A Must; J Spadano; E H Coakley; A E Field; G Colditz; W H Dietz
Journal:  JAMA       Date:  1999-10-27       Impact factor: 56.272

3.  Ghrelin induces adiposity in rodents.

Authors:  M Tschöp; D L Smiley; M L Heiman
Journal:  Nature       Date:  2000-10-19       Impact factor: 49.962

4.  Laparoscopic sleeve gastrectomy with staple line buttress reinforcement in 116 consecutive morbidly obese patients.

Authors:  Richdeep S Gill; Noah Switzer; Mike Driedger; Xinzhe Shi; Andrey Vizhul; Arya M Sharma; Daniel W Birch; Shahzeer Karmali
Journal:  Obes Surg       Date:  2012-04       Impact factor: 4.129

5.  Ghrelin and adipose tissue regulatory peptides: effect of gastric bypass surgery in obese humans.

Authors:  Camilla Holdstock; Britt Edén Engström; Margareta Ohrvall; Lars Lind; Magnus Sundbom; F Anders Karlsson
Journal:  J Clin Endocrinol Metab       Date:  2003-07       Impact factor: 5.958

Review 6.  Dysfunctions of leptin, ghrelin, BDNF and endocannabinoids in eating disorders: beyond the homeostatic control of food intake.

Authors:  Palmiero Monteleone; Mario Maj
Journal:  Psychoneuroendocrinology       Date:  2013-01-11       Impact factor: 4.905

7.  Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity.

Authors:  Joan Vendrell; Montserrat Broch; Nuria Vilarrasa; Ana Molina; Jose Manuel Gómez; Cristina Gutiérrez; Immaculada Simón; Joan Soler; Cristóbal Richart
Journal:  Obes Res       Date:  2004-06

Review 8.  Actions and therapeutic pathways of ghrelin for gastrointestinal disorders.

Authors:  Michael Camilleri; Athanasios Papathanasopoulos; Suwebatu T Odunsi
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2009-06       Impact factor: 46.802

9.  Ghrelin: a gut-brain hormone: effect of gastric bypass surgery.

Authors:  Bruno Geloneze; Marcos A Tambascia; Victor F Pilla; Sylka R Geloneze; Enrico M Repetto; José C Pareja
Journal:  Obes Surg       Date:  2003-02       Impact factor: 4.129

Review 10.  Changes in gut hormones after bariatric surgery.

Authors:  R P Vincent; C W le Roux
Journal:  Clin Endocrinol (Oxf)       Date:  2007-12-20       Impact factor: 3.478
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  20 in total

1.  The Association Between Salivary Ghrelin Levels with Anthropometric Measures in Underweight, Normal, Overweight and Obese Healthy Adult Males.

Authors:  Mona Mohamed Ibrahim Abdalla; Soon Siew Choo
Journal:  Eur Endocrinol       Date:  2020-02-28

2.  Plasma ghrelin levels after laparoscopic sleeve gastrectomy in obese individuals.

Authors:  Garima Sharma; Prabhdeep S Nain; Pulkit Sethi; Ashish Ahuja; Sarit Sharma
Journal:  Indian J Med Res       Date:  2019-04       Impact factor: 2.375

3.  Coincidental Detection of Gastrointestinal Stromal Tumors During Laparoscopic Bariatric Procedures-Data and Treatment Strategy of a German Reference Center.

Authors:  Orestis Lyros; Yusef Moulla; Matthias Mehdorn; Katrin Schierle; Robert Sucher; Arne Dietrich
Journal:  Obes Surg       Date:  2019-06       Impact factor: 4.129

4.  Female obesity and infertility: outcomes and regulatory guidance.

Authors:  Susanna Marinelli; Gabriele Napoletano; Marco Straccamore; Giuseppe Basile
Journal:  Acta Biomed       Date:  2022-08-31

Review 5.  Obesity I: Overview and molecular and biochemical mechanisms.

Authors:  Robert H Lustig; David Collier; Christopher Kassotis; Troy A Roepke; Min Ji Kim; Etienne Blanc; Robert Barouki; Amita Bansal; Matthew C Cave; Saurabh Chatterjee; Mahua Choudhury; Michael Gilbertson; Dominique Lagadic-Gossmann; Sarah Howard; Lars Lind; Craig R Tomlinson; Jan Vondracek; Jerrold J Heindel
Journal:  Biochem Pharmacol       Date:  2022-04-05       Impact factor: 6.100

Review 6.  Beyond the Calories-Is the Problem in the Processing?

Authors:  Janese Laster; Leigh A Frame
Journal:  Curr Treat Options Gastroenterol       Date:  2019-12

7.  Long-Term Changes in Leptin, Chemerin, and Ghrelin Levels Following Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy.

Authors:  Mohamed Abdalla Salman; Mohamed El-Ghobary; Ahmed Soliman; Mohammad El Sherbiny; Tarek Elsayed Abouelregal; Amr Albitar; Ahmed Abdallah; Hani Maurice Sabri Mikhail; Mohammed A Nafea; Ahmed Abd El Aal Sultan; Hossam E Elshafey; Hossam El-Din Shaaban; Ayman Azzam; Ghada M K GabAllah; Ahmed Abdallah Salman
Journal:  Obes Surg       Date:  2020-03       Impact factor: 4.129

8.  Randomized trial of weight loss on circulating ghrelin levels among breast cancer survivors.

Authors:  Leah Puklin; Brenda Cartmel; Maura Harrigan; Lingeng Lu; Fang-Yong Li; Tara Sanft; Melinda L Irwin
Journal:  NPJ Breast Cancer       Date:  2021-05-11

9.  Effects of acyl-coenzyme A binding protein (ACBP)/diazepam-binding inhibitor (DBI) on body mass index.

Authors:  Hui Chen; Gerasimos Anagnostopoulos; Léa Montégut; Adrien Joseph; Antoine Lafarge; Omar Motiño; Maria Castedo; Maria Chiara Maiuri; Karine Clément; Safae Terrisse; Anne Laure Martin; Ines Vaz-Luis; Fabrice Andre; Franziska Grundler; Françoise Wilhelmi de Toledo; Frank Madeo; Laurence Zitvogel; François Goldwasser; Benoit Blanchet; Frédéric Fumeron; Ronan Roussel; Isabelle Martins; Guido Kroemer
Journal:  Cell Death Dis       Date:  2021-06-09       Impact factor: 8.469

Review 10.  Diabetes remission after bariatric surgery.

Authors:  Maryna Chumakova-Orin; Carolina Vanetta; Dimitrios P Moris; Alfredo D Guerron
Journal:  World J Diabetes       Date:  2021-07-15
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