Literature DB >> 3087355

Selective inhibition of leukotriene C4 synthesis in human neutrophils by ethacrynic acid.

K H Leung.   

Abstract

Addition of glutathione S-transferase inhibitors, ethyacrynic acid (ET), caffeic acid (CA), and ferulic acid (FA) to human neutrophils led to inhibition of leukotriene C4 (LTC4) synthesis induced by calcium ionophore A23187. ET is the most specific of these inhibitors for it had little effect on LTB4, PGE2 and 5-HETE synthesis. The inhibition of LTC4 was irreversible and time dependent. ET also had little effect on 3H-AA release from A23187-stimulated neutrophils.

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Year:  1986        PMID： 3087355     DOI： 10.1016/0006-291x(86)91195-2

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Respective role of lipoxygenase and nitric oxide-synthase pathways in plasma histamine-induced macromolecular leakage in conscious hamsters.

Authors:  G Gimeno; P H Carpentier; S Desquand-Billiald; M Finet; R Hanf
Journal:  Br J Pharmacol       Date:  1999-04       Impact factor: 8.739

2.  The effects of 5-lipoxygenase inhibitors and leukotriene antagonists on the development of gastric lesions induced by nonsteroidal antiinflammatory drugs in mice.

Authors:  K D Rainsford
Journal:  Agents Actions       Date:  1987-08

3.  Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve.

Authors:  G Le Filliatre; S Sayah; V Latournerie; J F Renaud; M Finet; R Hanf
Journal:  Br J Pharmacol       Date:  2001-04       Impact factor: 8.739

4.  Glutathione analogues as novel inhibitors of rat and human glutathione S-transferase isoenzymes, as well as of glutathione conjugation in isolated rat hepatocytes and in the rat in vivo.

Authors:  S Ouwerkerk-Mahadevan; J H van Boom; M C Dreef-Tromp; J H Ploemen; D J Meyer; G J Mulder
Journal:  Biochem J       Date:  1995-05-15       Impact factor: 3.857

5.  Inhibition of cell proliferation and glutathione S-transferase by ascorbyl esters and interferon in mouse glioma.

Authors:  A K Naidu; M Wiranowska; S H Kori; K C Roetzheim; A P Kulkarni
Journal:  J Neurooncol       Date:  1993-04       Impact factor: 4.130

6.  Human epidermis transforms exogenous leukotriene A4 into peptide leukotrienes: possible role in transcellular metabolism.

Authors:  L Iversen; P Kristensen; B Grøn; V A Ziboh; K Kragballe
Journal:  Arch Dermatol Res       Date:  1994       Impact factor: 3.017
  6 in total

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