Outcome of surgical repair of adult digital nerve injury: a systematic review.

OBJECTIVES: A systematic review to assess the evidence supporting surgical repair of digital nerve injury versus no repair in adults in terms of clinical outcomes.
DESIGN: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses-compliant systematic review with methodology based on the Cochrane Handbook of Systematic Reviews of Interventions. DATA SOURCES: Databases included OvidMEDLINE, EMBASE, AMED, clinicaltrials.gov and the Cochrane Database of Systematic Reviews, searched from inception until 10 November 2018. ELIGIBILITY CRITERIA: Adult digital nerve injury in which either direct repair or no repair was undertaken and an outcome measure was recorded. DATA EXTRACTION AND SYNTHESIS: Study data extracted included demographics, injury type and extent, timing, treatment details, outcome data and time points, adverse outcomes, hand therapy and return to work. The National Institute of Health quality assessment tool for case series was used to assess risk of bias.
RESULTS: Thirty studies were included. One compared surgical repair with non-repair. All studies were case series of between 15 and 110 nerve injuries, with heterogeneous patient, injury and treatment characteristics. Two studies detailed nerve repair without magnification. Static 2-point discrimination (s2PD) was the most commonly reported outcome measure. Return of protective sensation was achieved in most cases in the nerve repair and no nerve repair groups. Repair resulted in better s2PD than no repair, but <25% repaired nerves achieved normal levels. Adverse outcomes were similar between repair and no repair groups.
CONCLUSIONS: Only level IV evidence is available to support surgical repair of digital nerves in adults. Return of normal sensibility is uncommon and almost all unrepaired nerves regained protective sensation by 6 months and all patients declined further surgery. There was no difference in adverse outcomes. There is currently a lack of high-quality evidence to support surgical repair of digital nerve injuries in adults and further research is needed. PROSPERO REGISTRATION NUMBER: CRD42017065092. © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, using methodology based on the Cochrane Handbook for Systematic Reviews of Interventions.

Using a comprehensive search strategy, all available and relevant published literature on this topic was included for evaluation.

The quality of the included studies was low and were at high risk of bias.

Surgical techniques, including the use of magnification have evolved since some of the earlier studies.

Outcome data were incompletely and variably reported across the included studies.

Introduction

The incidence of digital nerve injuries in a typical European urban district is 6.2 per 100 000 inhabitants per year.1 They arise from a mixture of domestic and work-related accidents and occur in all age groups. They most commonly occur in the working age population and are 2–5 times more common in men compared with women.1–6 Standard practice following digital nerve injury is direct end-to-end surgical repair of the nerve using microsutures, with alternative techniques described if a nerve gap prevents direct repair.7–11

A conservative estimated cost to the UK National Health Service of digital nerve injury and repair is £10 million per year. This does not consider patient-related costs of time off work and loss of income.12 The perceived advantage of performing surgical repair is that direct coaptation of the nerve endings is more likely to result in a better outcome for the patient and a lower incidence of neuroma than not repairing it. The most commonly reported outcome measures following repair include static or moving 2-point discrimination (s2PD or m2PD), pressure threshold detection and pain or temperature sensitivity.13–16 Less commonly reported measures include return to work, patient satisfaction and incidence of complications. Patient reported outcome measures are sparsely used in studies of digital nerve repair. Potential common complications from either repair or non-repair include neuroma and cold intolerance.3 4

Objective

The aim of this systematic review is to rigorously evaluate the quality of the evidence for surgical repair of unilateral adult digital nerve injury compared with no surgical repair; and to determine whether the outcomes and complications following surgical repair of a digital nerve injury in adults are superior when compared with no surgical repair.

Methods

This review was produced and reported in accordance to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines with methodology based on the Cochrane Handbook for Systematic Reviews of Interventions.17 A protocol was developed and locally peer-reviewed a priori and registered in concordance with best practice in systematic reviews.

Search strategy

The primary author (RLED) carried out a full systematic literature search of all records in the following databases: OvidMEDLINE (including OvidMEDLINE In-Process and Other Non-Indexed Citations), EMBASE, AMED, clinicaltrials.gov and the Cochrane Database of Systematic Reviews. The search strategy (online supplementary appendix 1) was developed in conjunction with a medical information specialist. Both ‘free-text term’ and ‘MeSH term’ searches were completed, using variations of the keywords ‘digital nerve’, ‘injury’, ‘nerve injury’, ‘nerve repair’, ‘nerve surgery’ and were combined using Boolean operators.18 All languages were considered. The databases were searched from inception until 13 November 2018. All search results were merged and duplicate citations were discarded. Two authors screened titles and abstracts independently (RLED and JCRW) and studies unrelated to the research objective were discarded. The full texts of the relevant papers were retrieved and examined by each author independently for consideration for inclusion/exclusion based on predefined stratified criteria (figure 1—study attrition algorithm). The final list of the included studies was compared and discussed between all authors. The reference lists of the included papers and previous reviews were examined to ensure relevant studies had been considered. Any disparities regarding inclusion of articles were discussed between the authors and a joint decision was made based on the inclusion criteria. The published data from included studies were scrutinised for reporting of outcomes. If some relevant data were not available for extraction, then the authors of the study were contacted by email with a specific data request. If there was no reply, a reminder email was sent after 2 weeks. If we received no response, then we sent a further email and waited for 8 weeks for reply. If we still received no response, then the study was excluded and the authors notified.

Figure 1

Preferred Reporting Items for Systematic Reviews and Meta-Analyses study attrition algorithm.

Data extraction and analysis

Data collection and analysis was performed in accordance with the Cochrane Handbook of Systematic Reviews of Interventions, where applicable.17 Data were extracted onto a predefined electronic data extraction form by author (RLED), which was checked by the other authors separately. Data extracted from each paper included patient and injury demographics (gender, age, smoking status, injury type and extent including arterial injury), the timing and details of treatment (neurorrhaphy, other surgical techniques and no nerve repair) including suture gauge, use of magnification, experience level of surgeon, aftercare including hand therapy provision, outcome measures (any) and time of outcome measurement, plus any complications or negative outcomes. Descriptive statistics were performed for patient demographics and key outcomes where possible to allow for narrative synthesis. Formal meta-analysis was not performed due to a lack of comparative studies, variable outcome reporting and a consistently high risk of bias based on study design.

Risk of bias

The review authors (RLED and JCRW) assessed risk of bias for each study using National Institute of Health (NIH) tool for appraisal of case series. The tool was developed by the National Heart, Lung and Blood Institute and Research Triangle Institute International.19 This tool is designed specifically for methodological quality assessment in case series and as such was the most appropriate tool for use in this systematic review. Based on nine domains, each case series is assessed and given an overall rating: good, fair or poor (online supplementary appendix 2). We appraised the quality of evidence for each outcome based on the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach.20

Public and patient involvement

Patient and public involvement was not part of this systematic review but has been undertaken subsequently.

Results

Study selection

A total of 4036 records were screened using a study attrition algorithm (figure 1). Following step 3 of the algorithm, 73 full-text records were retrieved. One record in a Turkish language publication and two in Russian could not be obtained. Of the 73 records obtained, 15 were excluded since they detailed studies using only nerve graft or nerve wrap techniques rather than direct nerve repair. Three were excluded as being descriptive, non-clinical studies and one because there was insufficient detail to include. The corresponding author of this paper did not respond to a request for further information. A further 26 were excluded for other reasons (reporting of neuroma treatments, insufficient outcome measures recorded, not possible to distinguish mixed nerve repair results from digital nerve repairs). These left 28 studies from the original search which met the inclusion criteria and were suitable for data extraction and analysis. During review of the 73 records, the reference lists were scrutinised and those that appeared potentially relevant were obtained and screened. On this basis, one further study was included. One extra study was identified later, during manuscript write-up, which had been published since the original search. The total number of studies therefore included in this review was 30.

As per rigorous systematic review methodology, the terms of the original search were to scrutinise the databases from inception to the present day and therefore some historical articles were identified and included in our analysis. No papers were excluded based on publication date as this would have introduced selection bias and compromises methodology. Of course, certain aspects of surgical technique have evolved since the earlier articles were published and so we have ensured that the results are presented clearly to show results from different eras.

Study characteristics

Data were extracted from these 30, level IV studies to detail injury mechanisms, patient demographics, surgical intervention and timing of outcome measurements (table 1).

Table 1

Characteristics of included studies

Author	Year	Study type	Attrition rate	Number of digital nerve repairs analysed	Other structures injured	Injury mechanism	Intervention(s) and control	Timing of intervention (acute, delayed, mixed and unknown)	Average age of patient (years)	Children included (age<18)	Male:female ratio (rounded up)
Bunnell et al21	1928	Retrospective	Unknown	45	Yes	Various	Repair or graft	Delayed	Unknown	Unknown	Unknown
Shaffer and Cleveland32	1950	Prospective	None at 3 months	36	Yes	Unknown	Repair	Delayed	Unknown	Unknown	Unknown
Nemethi20	1956	Retrospective	Unknown	Not documented	Yes	Various	Repair	Acute	Unknown	Unknown	Unknown
Buncke50	1972	Retrospective	Unknown	20	Unknown	Various	Repair	Unknown	32	Yes	2:1
Holst51	1975	Retrospective	27%	Not documented	Yes	Sharp	Repair	Delayed	Unknown	Yes	Unknown
Poppen et al44	1979	Retrospective	50%	74	Yes	Sharp	Repair	Delayed	29	Yes	2:1
Young et al47	1981	Prospective	Unknown	34	Yes	Various	Epineural vs fascicular repair	Delayed	29	Yes	2:1
Khuc et al33	1982	Retrospective	32%	110	Yes	Various	Repair, neurolysis or graft	Mixed	32	Yes	2:1
Sullivan52	1985	Retrospective	None	42	Yes	Various	Repair (three patients with no repair)	Mixed	Unknown	No	Unknown
Mailander et al43	1988	Retrospective	17%	107	Yes	Various	Repair	Acute	Unknown	Unknown	Unknown
Altissimi et al39	1991	Retrospective	None	54	Yes	Various	Repair	Acute	35	Yes	4:1
Pereira et al30	1991	Retrospective	None	30	Yes	Sharp	Repair or graft	Mixed	Unknown	Yes	3:1
Goldie et al29	1992	Retrospective	Unknown	30	Yes	Unknown	Repair	Mixed	40	No	Unknown
Chaise et al25	1993	Retrospective	Unknown	110	No	Sharp	Repair	Acute	31	Yes	Unknown
Chow and Ng49	1993	Prospective	35%	72	Yes	Unknown	Repair vs non-repair	Acute	Unknown	Unknown	3:1
Kallio 41	1993	Retrospective	20%	151	Yes	Various	Repair or graft	Delayed	29	Yes	3:1
Al-Ghazal et al38	1994	Retrospective	15%	88	Yes	Various	Repair	Acute	Unknown	Yes	2:1
Elias et al26	1994	Retrospective	Unknown	83	Unknown	Various	Repair	Unknown	30	Yes	5:1
Vertruyen et al45	1994	Retrospective	42%	65	Yes	Various	Repair	Unknown	23	Unknown	3:1
Efstathopoulos et al31	1995	Retrospective	10%	64	Yes	Various	Repair	Acute	Unknown	Yes	5:1
Tadjalli et al27	1995	Retrospective	83%	37	Yes	Various	Repair	Unknown	33	Unknown	2:1
Wang et al46	1996	Retrospective	Unknown	76	No	Various	Repair or graft	Unknown	Unknown	No	Unknown
Cheng et al40	2001	Prospective	18%	65	Yes	Unknown	Repair±early sensory re-education	Acute	40	Unknown	3:1
Segalman53	2001	Retrospective	80%	19	Yes	Various	Repair	Unknown	64	No	1:1
Portincasa54	2007	Retrospective	Unknown	Not documented	Yes	Unknown	Repair or graft	Mixed	Unknown	Unknown	Unknown
Hohendorff et al3	2009	Retrospective	26%	57	Yes	Various	Repair of nerve±digital artery repair	Delayed	39	No	3:1
Lohmeyer et al4	2009	Retrospective	75%	58	Yes	Various	Repair or graft	Unknown	41	Yes	3:1
Thomas et al5	2015	Retrospective	5%	25	Yes	Sharp	Repair with loupe vs microscope	Acute	45	No	3:1
Fakin et al2	2016	Retrospective	46%	93	Yes	Various	Repair	Acute	43	No	2:1
Huber et al36	2017	Retrospective	77%	15	Yes	Various	Repair or conduit	Mixed	39	Unknown	4:1

In total, 26 studies were retrospective case series and four were prospective. Seven included data on non-digital nerve injuries, but the results from the digital nerve repairs specifically could mostly be distinguished from the results in general. Eight studies included graft or conduit use as well as direct nerve repair, but again the nerve repair results could be distinguished from the other results. In 28 studies, other injuries were present, such as tendon injury or fracture, though the study attrition algorithm excluded studies where all cases were revascularisation and replantation injuries. Three studies did not document the number of digital nerve injuries included, the others ranged from 15 to 110 digital nerve injuries, in patients with an age range of 1–88 years, though age was not documented in six studies. There were significantly more male than female patients in 19 out of 20 studies that documented patient gender (up to 5:1 ratio).

Injury types were mixed in 20 studies, sharp in five studies and not documented in five studies. Time from injury to surgical repair varied from 0 to 30 months, though 17 studies had all, or nearly all, immediate repairs. Nerve repair sutures used included 6–0 or 7–0 silk in the earlier studies (Bunnell described his suture as ‘finest silk’) and nylon in later studies, ranging from 8-0 gauge to 10–0 gauge. Magnification was used in 20 studies, either loupes or microscope, not specified or not always used in eight studies and not used in two, which were both written prior to the introduction of the operating microscope.21 22

Outcome measures

s2PD first described by Weber in 1835 was the most widely recorded outcome measure (26 studies). Ideally, this was recorded as an absolute value, with comparison to the corresponding portion of the contralateral, uninjured finger. Normal values in an uninjured finger-tip range from 2 to 6 mm. Classification schemes such as Medical Research Council scoring system from 1954, modified by MacKinnon and Dellon (often referred to as Modified Highet (figure 2), group a range of values into subjective headings.23–25 This scoring system was frequently used in the studies to report results following nerve repair. Using the Modified Highet classification, ‘Grade 4’ or ‘Excellent’ recovery may have an s2PD of 6 mm, which could be up to 4 mm wider than preinjury or the contralateral digit. Equally, a ‘Poor’ outcome according to Highet could have a large s2PD of >15 mm but with no pain or functional loss. The way in which s2PD was recorded varied between studies, making comparisons difficult. We have attempted to simplify comparisons by extracting only the Highet grade 4 results from each paper, where s2PD was 6 mm or less following nerve repair (table 2). The range of Highet grade 4 results achieved was between 8% and 60% following nerve repair, with an average across the studies of 24%.

Figure 2

Modified Highet classification of nerve recovery.

Table 2

Primary outcome of s2PD for digital nerve repair

Primary author and year	Number of digital nerve repairs analysed	Timing of results measurement (m=months y=years)	Number of nerve repairs with s2PD 6 mm or less: Highet grade 4	Children (age<18) included
Bunnell 192821	45	Unknown	Unknown	Unknown
Shaffer and Cleveland et al 195032	36	3–12 m	Unknown	Unknown
Nemethi 195620	Unknown	Unknown	Unknown	Unknown
Buncke 197250	20	Unknown	12 (60%)	Yes
Holst 197551	Unknown	26 m	Unknown	Yes
Poppen et al 197944	74	5y	12 (16%)	Yes
Young et al 198147	34	Unknown	11 (32%)	Yes
Khuc et al 198233	110	6m	9 (8%)	Yes
Sullivan 198552	42	6.5-8y	9 (21%)	No
Mailander et al 198843	107	6–60 m	25 (23%)	Unknown

s2PD, static 2-point discrimination.

Other objective recorded outcome measures recorded included m2PD as described by Dellon, pressure threshold testing, sharp/dull discrimination (protective sensation), temperature discrimination, stereognosis, sweating and nerve conduction.15 23

Documentation of patient recorded outcome measures was much less common. Three of the more recent studies recorded the Disability of the Arm, Shoulder and Hand score, one recorded return to work as well as a score of leisure, self-care and productivity and eight further studies recorded the patients’ opinion of their treatment. All eight had a different method for recording patient opinion. In six, this was in the form of a rating of outcome for example, ‘excellent, good, fair, poor’ or ‘grade 1–4’ or ‘very happy, reasonable, unhappy’ and in two, the patient was asked to subjectively express their return of sensation.

Predictive factors

Using s2PD as the prime outcome measure, the degree of nerve recovery following repair was influenced by other factors in several studies. These included uncontrollable variables such as the age of patient, the severity, mechanism or level of the original injury and controllable variables such as the experience level of the operating surgeon (table 3). The effects of these predictive factors were inconsistent across studies, with the notable exception of patient age and surgical experience level. Certain factors historically thought to influence outcome such as the smoking status of the patient, the presence of a concomitant digital artery injury and the time interval between injury and repair of the nerve were not consistently shown to have an impact.

Table 3

Predictive factors for sensory recovery following nerve repair

Author and year	Positive predictive factors for sensory recovery	Factors with no impact on sensory recovery
Shaffer and Cleveland 195032	Level of injury	Timing of repair
Poppen et al 197944	Age<20	Timing of repair, injury severity
Young et al 198147	Age<20<40
Mailänder et al 198843	Age<10…<60, injury severityExperience level of surgeon	Injury mechanism
Altissimi et al 199139	Age<10<40	Digital artery injury, injury mechanism
Chaise et al 199325	Age
Kallio 199341	Age<15<40 Timing of repair<3 months<12 months	Level of injury, injury mechanism
Al-Ghazal et al 199438	Age<12, smoking status (favouring non-smokers) Injury mechanism	Injury severity
Elias et al 199426	Age<40, injury mechanism, timing of repairExperience level of surgeon	Injury severity, digital artery injury
Vertruyen et al 199445	Age<30, injury severity
Efstathopoulos et al 199531	Age<10 <40
Tadjalli et al 199527	Injury severity (score, combining injury mechanism, severity and other factors)
Wang et al 199646	Age<40, injury mechanism
Cheng et al 200140	Age, early sensory re-education
Hohendorff et al 20093		Smoking status, injury mechanism, Digital artery repair
Lohmeyer et al 20094	Age<20	Injury severity, smoking statusSystemic disease for example, diabetes
Fakin et al 20162	Experience level of surgeon	Smoking status, age (study used adults only) Injury mechanism, digital artery injury Postoperative immobilisation

Factors in italics variously described as ‘predictive’ and ‘not predictive’ across different papers.

Adverse outcomes

Eight studies documented the neuroma incidence after digital nerve repair (table 4) and one further study mentioned neuroma without giving the incidence. Neuroma was reported in 22 out of 475 patients across these eight studies, giving an incidence of 4.6%. The range was from 0% to 20%. In the two studies that each had a cohort of unrepaired nerves, the neuroma incidence in their combined cohort was in 2 in 39 patients (5%). Five studies documented cold intolerance in repaired nerves, with incidences of 2%, 8%, 39%, 44% and 53%.3 4 26–28 It is possible that this problem was under-reported across the other 25 studies, as cold intolerance is known to be very common even 2 years after hand injuries.29

Table 4

Neuroma incidence following nerve repair

Author and year	Number of repaired digital nerves in study	Neuroma incidence
Shaffer and Cleveland 195032	71	3 (4%)
Buncke 197250	20	4 (20%)
Khuc et al 198233	110	4 (4%)
Sullivan 198552	42	3 (7%)
Pereira et al 199130	30	5 (17%)
Chow and Ng 199349	72	0%
Tadjalli et al 199527	37	1 (3%)
Fakin et al 20162	93	2 (2%)
8/30 studies reported a neuroma incidence	Total number of cases: 475	Pooled incidence (22/475): 4.6%

Hyperaesthesia or unpleasant sensory disturbance had a high incidence in two studies of repaired nerves, with 67% and 40% patients affected for up to 2 years.30 31 Three other nerve repair papers give an incidence of unpleasant sensory disturbance of 8%, 12% and 1%.3 32 Chronic regional pain syndrome was also mentioned following nerve repair.33

Infection was only mentioned in two papers, one with an incidence of 8% and the other 3.6%.28 34 This is likely due to the retrospective nature of most studies, where the patients were recalled for testing often long after their initial discharge from hospital care and the paper focused on mid- to long-term test results rather than self-limiting or treated complications. No study reported any cases of iatrogenic injury or other hospital error and none explored whether patients had symptoms relating to their surgical scar as opposed to the scar from their original injury.

Assessment of risk of bias

All of the included studies were case series; they attract a Centre for Evidence Based Medicine level IV classification, and therefore an inherently high risk of bias.35 Based on the NIH Quality Assessment Tool for Case Series, nine studies were deemed to have a ‘Good’ quality rating, 15 ‘Fair’ and six ‘Poor’ (online supplementary appendix 2).19 The most common reasons for a ‘Fair’ or ‘Poor’ rating were the non-consecutive nature of cases, high attrition rates, lack of clearly defined objectives other than a simple reporting of a series and opaque results lacking in detail. According to the GRADE criteria, no recommendations for either repair or no repair can be made based on the currently available evidence for any of our primary or secondary outcomes.20

Discussion

Summary of evidence

This systematic review assessed the quality of the evidence supporting surgical repair of digital nerve injuries in adults and aimed to determine differences in outcomes between surgical repair and no repair. Thirty published series of results were identified from different centres around the world since 1928, predominantly retrospective case series. Criticism could be made against including historical studies from the 1920s and 1950s, where surgical techniques, in particular the use of magnification has since evolved; however, the stated use of magnification is not ubiquitous even among the much later studies, for example from 2017.36

To selectively exclude studies which do not expressly state magnification was used (10 studies) would make assumptions that magnification has a significant impact on outcome, introducing selection bias. This would be counter to established systematic review methodology and would reduce the validity of this review. Furthermore, it was not actually possible to extract the most important data (Highet grade 4 s2PD) from these papers for comparison and therefore their inclusion does not affect the conclusions of the review with regard to outcomes. The same argument can be used for the inclusion of studies where the timing of repair, though mostly acute, was somewhat variable, in particular since timing of repair was not found to affect outcome in this review. Other studies, however, that did not meet the criteria for inclusion in this review have suggested that early repair is beneficial.37

s2PD was the primary outcome measure selected. S2PD results were often grouped according to the Modified Highet Classification Grade 0 (no sensory recovery) to Grade 4 (excellent sensory recovery). There was a wide range of s2PD results after surgical repair: one study of 20 patients reported 60% achieving s2PD similar to expected preinjury levels (Grade 4) and one study of 110 patients reported only 8% achieving this level. Grouping together the 19 studies that showed this information, the overall Grade 4 s2PD result after nerve repair was only 24%. Ten of these studies included children (age <18) and a further six may have done. Younger age is associated with better outcomes and therefore it is possible that the ‘excellent’ results seen in some studies was influenced by patient age.4 26 27 32 38–47 It is therefore clear that despite surgical repair, very few patients actually achieve ‘normal’ preinjury levels of sensation and in fact the data may be skewed in favour of a better outcome due to younger patients being included in studies.

The 30 papers were scrutinised for the incidence of nerve-related complications such as neuroma and cold intolerance. Formation of a clinically problematic neuroma is often quoted by surgeons to justify digital nerve repair yet the incidence of neuroma and cold intolerance was inconsistently reported. The neuroma incidence varied from 0% to 20% with a pooled incidence of 4.6% in the repaired group and 5% in the unrepaired group. For cold intolerance, this varied from 2% to 53%. Therefore, there is no evidence to suggest that these complications are reduced by surgical repair of digital nerve injuries.

The age of the patient was a significant predictive factor for s2PD outcome following nerve repair in 14 studies.4 26 27 32 38–47 Although this systematic review evaluated adult digital nerve injury, it was apparent from the literature that children got much better results than adults.48 Indeed, younger adults got better outcomes than older adults, with the results gradually worsening with an older cohort. The experience level of the surgeon was also shown to improve outcomes.3 27 43 Other possible predictive factors were significant in some studies and not significant in others. These factors included injury mechanism, injury extent, the timing of surgical repair, smoking status and digital artery injury.

Four studies compared different techniques of repair or rehabilitation. One compared the results between loupe and microscope magnification,6 one between patients treated with and without early tactile stimulation,40 one between epineural and fascicular nerve repairs,47 and one between patients with or without repair of the digital artery.4 From these studies, only early tactile stimulation was shown to have a beneficial effect on outcome.40

The study that compared nerve repair with no repair was a prospective case series with 72 repaired nerves and 36 unrepaired nerves.49 From the original sample of 132 patients, 47 were lost to follow-up. The study showed a significant difference in the s2PD achieved between repair and non-repair patients. Highet grade 4 sensory recovery was achieved in 25% of the repaired group and in none of the unrepaired group. However, none of the unrepaired group of patients chose to undergo further surgery to improve their outcome and 94% had achieved restoration of protective sensibility. This study also showed that in the unrepaired group, sensory recovery plateaued at 6 months post surgery whereas in the repaired group it continued to improve up to 24 months post repair.

Limitations

This systematic review aimed to assess the quality of the evidence for surgical repair of unilateral adult digital nerve injury compared with no surgical repair and to explore differences in outcomes. We were limited by the methodological quality of the included studies, which were exclusively case series (level 4 evidence). This inevitably introduces high risk of bias and the data reported should be interpreted with this in mind. There was heterogeneous and incomplete outcome data reporting across the included studies, which also limits the strength of conclusions. Finally, despite rigorous systematic review methodology and comprehensive literature retrieval measures, it is possible that studies may have been missed from this review.

Conclusion

There is weak evidence to support digital nerve repair in adults with isolated digital nerve injury, in terms of return of normal sensibility and prevention of neuroma. Return of normal sensibility is uncommon and almost all unrepaired nerves regained protective sensation by 6 months and all patients declined further surgery. There was no difference in adverse outcomes. Some of the published literature is old and heterogeneous, with variability in surgical technique and outcome reporting and is limited to observational case series. There is also insufficient evidence not to support the current practice of carrying out surgical repair; however, further research is required to improve the justification for the treatment of this injury.