| Literature DB >> 30872492 |
Svetoslav Chakarov1, Hwee Ying Lim2, Leonard Tan1, Sheau Yng Lim2, Peter See1, Josephine Lum1, Xiao-Meng Zhang1, Shihui Foo1, Satoshi Nakamizo1, Kaibo Duan1, Wan Ting Kong1, Rebecca Gentek3, Akhila Balachander1, Daniel Carbajo1, Camille Bleriot1, Benoit Malleret1,2, John Kit Chung Tam4, Sonia Baig5, Muhammad Shabeer5, Sue-Anne Ee Shiow Toh5, Andreas Schlitzer6, Anis Larbi1, Thomas Marichal7,8,9, Bernard Malissen3,10, Jinmiao Chen1, Michael Poidinger1, Kenji Kabashima1,11, Marc Bajenoff3, Lai Guan Ng1, Veronique Angeli2, Florent Ginhoux12.
Abstract
Macrophages are a heterogeneous cell population involved in tissue homeostasis, inflammation, and various pathologies. Although the major tissue-resident macrophage populations have been extensively studied, interstitial macrophages (IMs) residing within the tissue parenchyma remain poorly defined. Here we studied IMs from murine lung, fat, heart, and dermis. We identified two independent IM subpopulations that are conserved across tissues: Lyve1loMHCIIhiCX3CR1hi (Lyve1loMHCIIhi) and Lyve1hiMHCIIloCX3CR1lo (Lyve1hiMHCIIlo) monocyte-derived IMs, with distinct gene expression profiles, phenotypes, functions, and localizations. Using a new mouse model of inducible macrophage depletion (Slco2b1 flox/DTR), we found that the absence of Lyve1hiMHCIIlo IMs exacerbated experimental lung fibrosis. Thus, we demonstrate that two independent populations of IMs coexist across tissues and exhibit conserved niche-dependent functional programming.Entities:
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Year: 2019 PMID： 30872492 DOI： 10.1126/science.aau0964
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728