| Literature DB >> 31107246 |
Satoshi Watanabe1,2, Michael Alexander1, Alexander V Misharin1, G R Scott Budinger1.
Abstract
Macrophages are tissue-resident or infiltrated immune cells critical for innate immunity, normal tissue development, homeostasis, and repair of damaged tissue. Macrophage function is a sum of their ontogeny, the local environment in which they reside, and the type of injuries or pathogen to which they are exposed. In this Review, we discuss the role of macrophages in the restoration of tissue function after injury, highlighting important questions about how they respond to and modify the local microenvironment to restore homeostasis.Entities:
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Year: 2019 PMID: 31107246 PMCID: PMC6597225 DOI: 10.1172/JCI124615
Source DB: PubMed Journal: J Clin Invest ISSN: 0021-9738 Impact factor: 14.808