Literature DB >> 17803898

Molecular understanding and modern application of traditional medicines: triumphs and trials.

Timothy W Corson1, Craig M Crews.   

Abstract

Traditional medicines provide fertile ground for modern drug development, but first they must pass along a pathway of discovery, isolation, and mechanistic studies before eventual deployment in the clinic. Here, we highlight the challenges along this route, focusing on the compounds artemisinin, triptolide, celastrol, capsaicin, and curcumin.

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Year:  2007        PMID： 17803898      PMCID： PMC2507744          DOI： 10.1016/j.cell.2007.08.021

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  23 in total

1.  The capsaicin receptor: a heat-activated ion channel in the pain pathway.

Authors:  M J Caterina; M A Schumacher; M Tominaga; T A Rosen; J D Levine; D Julius
Journal:  Nature       Date:  1997-10-23       Impact factor: 49.962

2.  Chillies: from antiquity to urology.

Authors:  P Dasgupta; C J Fowler
Journal:  Br J Urol       Date:  1997-12

Review 3.  The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F.

Authors:  X Tao; P E Lipsky
Journal:  Rheum Dis Clin North Am       Date:  2000-02       Impact factor: 2.670

Review 4.  Curcumin: the story so far.

Authors:  R A Sharma; A J Gescher; W P Steward
Journal:  Eur J Cancer       Date:  2005-09       Impact factor: 9.162

5.  Determination of triptolide in root extracts of Tripterygium wilfordii by solid-phase extraction and reverse-phase high-performance liquid chromatography.

Authors:  Anita M Brinker; Ilya Raskin
Journal:  J Chromatogr A       Date:  2005-04-08       Impact factor: 4.759

6.  Identification of an antimalarial synthetic trioxolane drug development candidate.

Authors:  Jonathan L Vennerstrom; Sarah Arbe-Barnes; Reto Brun; Susan A Charman; Francis C K Chiu; Jacques Chollet; Yuxiang Dong; Arnulf Dorn; Daniel Hunziker; Hugues Matile; Kylie McIntosh; Maniyan Padmanilayam; Josefina Santo Tomas; Christian Scheurer; Bernard Scorneaux; Yuanqing Tang; Heinrich Urwyler; Sergio Wittlin; William N Charman
Journal:  Nature       Date:  2004-08-19       Impact factor: 49.962

7.  Artemisinins target the SERCA of Plasmodium falciparum.

Authors:  U Eckstein-Ludwig; R J Webb; I D A Van Goethem; J M East; A G Lee; M Kimura; P M O'Neill; P G Bray; S A Ward; S Krishna
Journal:  Nature       Date:  2003-08-21       Impact factor: 49.962

Review 8.  TRP channels and pain.

Authors:  Daniel N Cortright; James E Krause; Daniel C Broom
Journal:  Biochim Biophys Acta       Date:  2007-03-19

9.  Reaction of antimalarial endoperoxides with specific parasite proteins.

Authors:  W Asawamahasakda; I Ittarat; Y M Pu; H Ziffer; S R Meshnick
Journal:  Antimicrob Agents Chemother       Date:  1994-08       Impact factor: 5.191

10.  The quinine connection.

Authors:  D Greenwood
Journal:  J Antimicrob Chemother       Date:  1992-10       Impact factor: 5.790
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  177 in total

1.  Effect of Dan Hong injection on PON1, SOD activity and MDA levels in elderly patients with coronary heart disease.

Authors:  Xianming Su; Yajun He; Wei Yang; Ying Wang; Wei Zhang; Ying Wang
Journal:  Int J Clin Exp Med       Date:  2014-12-15

2.  Western healers in traditional Chinese medicine.

Authors:  Xue-Juan Li; Hong-Yu Zhang
Journal:  EMBO Rep       Date:  2008-02       Impact factor: 8.807

3.  Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?

Authors:  Hong-Fang Ji; Xue-Juan Li; Hong-Yu Zhang
Journal:  EMBO Rep       Date:  2009-02-20       Impact factor: 8.807

4.  Xenohormesis: sensing the chemical cues of other species.

Authors:  Konrad T Howitz; David A Sinclair
Journal:  Cell       Date:  2008-05-02       Impact factor: 41.582

5.  Curcumin derivatives promote Schwann cell differentiation and improve neuropathy in R98C CMT1B mice.

Authors:  Agnes Patzkó; Yunhong Bai; Mario A Saporta; István Katona; Xingyao Wu; Domenica Vizzuso; M Laura Feltri; Suola Wang; Lisa M Dillon; John Kamholz; Daniel Kirschner; Fazlul H Sarkar; Lawrence Wrabetz; Michael E Shy
Journal:  Brain       Date:  2012-12       Impact factor: 13.501

6.  Curcumin (diferuloylmethane) inhibits cell proliferation, induces apoptosis, and decreases hormone levels and secretion in pituitary tumor cells.

Authors:  Matthew Miller; Shenglin Chen; Jeffrey Woodliff; Sanjay Kansra
Journal:  Endocrinology       Date:  2008-05-01       Impact factor: 4.736

Review 7.  21st century natural product research and drug development and traditional medicines.

Authors:  Linh T Ngo; Joseph I Okogun; William R Folk
Journal:  Nat Prod Rep       Date:  2013-04       Impact factor: 13.423

8.  Modulation of Lipid Metabolism by Celastrol.

Authors:  Ting Zhang; Qi Zhao; Xuerong Xiao; Rui Yang; Dandan Hu; Xu Zhu; Frank J Gonzalez; Fei Li
Journal:  J Proteome Res       Date:  2019-02-12       Impact factor: 4.466

Review 9.  Phytochemicals in Ischemic Stroke.

Authors:  Joonki Kim; David Yang-Wei Fann; Raymond Chee Seong Seet; Dong-Gyu Jo; Mark P Mattson; Thiruma V Arumugam
Journal:  Neuromolecular Med       Date:  2016-05-18       Impact factor: 3.843

10.  Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies.

Authors:  Lynnie Trzoss; Jing Xu; Michelle H Lacoske; William C Mobley; Emmanuel A Theodorakis
Journal:  Chemistry       Date:  2013-03-22       Impact factor: 5.236
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