Literature DB >> 3086556

The lysine pathway as a target for a new genera of synthetic antibacterial antibiotics?

J M Girodeau, C Agouridas, M Masson, R Pineau, F Le Goffic.   

Abstract

Unsaturated analogues of diaminopimelic acid have been synthesized. The amino acids were designed so that they would be reversible or irreversible inhibitors of both of the two last enzymes of the lysine pathway. The compounds were tested with meso-diaminopimelate decarboxylase. trans-3,4-Didehydrodiaminopimelic acid (2) was found to be the most potent inhibitor. The antibacterial activities did not correlate with enzyme inhibiting activities. 4-Methylenediaminopimelic acid 4 showed strong antibacterial properties. It is suggested that L,L-diaminopimelate epimerase could be the target enzyme.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3086556     DOI： 10.1021/jm00156a021

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  15 in total

1.  Purification, crystallization and preliminary X-ray analysis of the regulatory subunit of aspartate kinase from Thermus thermophilus.

Authors:  Ayako Yoshida; Takeo Tomita; Tomohisa Kuzuyama; Makoto Nishiyama
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2007-01-17

2.  Synthesis of (E)-δ-hydroxy-β,γ-dehydroα-amino acids, a new class of vinylglycines by the rearrangement ofβ acetoxyallylglycine derivatives.

Authors:  M Kirihata; M Fukuari; T Izukawa; I Ichimoto
Journal:  Amino Acids       Date:  1995-12       Impact factor: 3.520

3.  Molecular cloning, characterization, and chromosomal localization of dapF, the Escherichia coli gene for diaminopimelate epimerase.

Authors:  C Richaud; W Higgins; D Mengin-Lecreulx; P Stragier
Journal:  J Bacteriol       Date:  1987-04       Impact factor: 3.490

4.  Structural characterization of Zn(II)-, Co(II)-, and Mn(II)-loaded forms of the argE-encoded N-acetyl-L-ornithine deacetylase from Escherichia coli.

Authors:  Ye Tao; Jacob E Shokes; Wade C McGregor; Robert A Scott; Richard C Holz
Journal:  J Inorg Biochem       Date:  2012-02-14       Impact factor: 4.155

5.  Kinetic and spectroscopic characterization of the E134A- and E134D-altered dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae.

Authors:  Ryan Davis; David Bienvenue; Sabina I Swierczek; Danuta M Gilner; Lakshman Rajagopal; Brian Bennett; Richard C Holz
Journal:  J Biol Inorg Chem       Date:  2006-01-19       Impact factor: 3.358

6.  Structural basis for catalysis by the mono- and dimetalated forms of the dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase.

Authors:  Boguslaw P Nocek; Danuta M Gillner; Yao Fan; Richard C Holz; Andrzej Joachimiak
Journal:  J Mol Biol       Date:  2010-02-04       Impact factor: 5.469

Review 7.  Lysine biosynthesis in bacteria: a metallodesuccinylase as a potential antimicrobial target.

Authors:  Danuta M Gillner; Daniel P Becker; Richard C Holz
Journal:  J Biol Inorg Chem       Date:  2012-12-08       Impact factor: 3.358

8.  Replacement of diaminopimelic acid by cystathionine or lanthionine in the peptidoglycan of Escherichia coli.

Authors:  D Mengin-Lecreulx; D Blanot; J van Heijenoort
Journal:  J Bacteriol       Date:  1994-07       Impact factor: 3.490

9.  Incorporation of LL-diaminopimelic acid into peptidoglycan of Escherichia coli mutants lacking diaminopimelate epimerase encoded by dapF.

Authors:  D Mengin-Lecreulx; C Michaud; C Richaud; D Blanot; J van Heijenoort
Journal:  J Bacteriol       Date:  1988-05       Impact factor: 3.490

10.  The dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae contains two active-site histidine residues.

Authors:  Danuta M Gillner; David L Bienvenue; Boguslaw P Nocek; Andrzej Joachimiak; Vincentos Zachary; Brian Bennett; Richard C Holz
Journal:  J Biol Inorg Chem       Date:  2008-08-19       Impact factor: 3.358
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.