Aik Hao Ng1,2, Mohammed S Alqahtani3,4, Layal K Jambi3,5, Sarah L Bugby3, John E Lees3, Alan C Perkins1,6. 1. 1 Radiological Sciences and Precision Imaging Beacon, School of Medicine, University of Nottingham , UK. 2. 2 National Cancer Institute , Putrajaya , Malaysia. 3. 3 Space Research Centre, Michael Atiyah Building, Department of Physics and Astronomy, University of Leicester , UK. 4. 4 Radiological Sciences Department, College of Applied Medical Sciences, King Khalid University , Abha , Saudi Arabia. 5. 5 Radiological Sciences Department, College of Applied Medical Sciences, King Saud University , Riyadh , Saudi Arabia. 6. 6 Medical Physics and Clinical Engineering, Nottingham University Hospitals NHS Trust , Nottingham , UK.
Abstract
OBJECTIVE: To examine the imaging capability of a novel small field of view hybrid gamma camera (HGC) using 125I seeds prior to surgical use. METHODS: The imaging performance of the camera system was assessed quantitatively and qualitatively at different source depths, source to collimator distances (SCD), activity levels, acquisition times and source separations, utilising bespoke phantoms. RESULTS: The system sensitivity and spatial resolution of the HGC for 125I were 0.41 cps/MBq (at SCD 48 mm) and 1.53 ± 0.23 mm (at SCD 10 mm) respectively. The camera was able to detect the 125I seed at a SCD of 63 mm (with no scattering material in place) in images recorded within a 1-min acquisition time. The detection of the seeds beneath scattering material (simulating deep-seated tumours) was limited to depths of less than 20 mm beneath the skin surface with a SCD of 63 mm and seed activity of 2.43 MBq. Subjective assessments of the hybrid images acquired showed the capability of the HGC for localising the 125I seeds. CONCLUSION: This preliminary ex vivo study demonstrates that the HGC is capable of detecting 125I seeds and could be a useful tool in radioactive seed localisation with the added benefit of providing hybrid optical γ images for guiding breast conserving surgery. ADVANCES IN KNOWLEDGE: The SFOV HGC could provide high resolution fused optical-gamma images of 125I radioactive seeds indicating the potential use in intraoperative surgical procedure such as RSL.
OBJECTIVE: To examine the imaging capability of a novel small field of view hybrid gamma camera (HGC) using 125I seeds prior to surgical use. METHODS: The imaging performance of the camera system was assessed quantitatively and qualitatively at different source depths, source to collimator distances (SCD), activity levels, acquisition times and source separations, utilising bespoke phantoms. RESULTS: The system sensitivity and spatial resolution of the HGC for 125I were 0.41 cps/MBq (at SCD 48 mm) and 1.53 ± 0.23 mm (at SCD 10 mm) respectively. The camera was able to detect the 125I seed at a SCD of 63 mm (with no scattering material in place) in images recorded within a 1-min acquisition time. The detection of the seeds beneath scattering material (simulating deep-seated tumours) was limited to depths of less than 20 mm beneath the skin surface with a SCD of 63 mm and seed activity of 2.43 MBq. Subjective assessments of the hybrid images acquired showed the capability of the HGC for localising the 125I seeds. CONCLUSION: This preliminary ex vivo study demonstrates that the HGC is capable of detecting 125I seeds and could be a useful tool in radioactive seed localisation with the added benefit of providing hybrid optical γ images for guiding breast conserving surgery. ADVANCES IN KNOWLEDGE: The SFOV HGC could provide high resolution fused optical-gamma images of 125I radioactive seeds indicating the potential use in intraoperative surgical procedure such as RSL.
Authors: Bas Pouw; Linda J de Wit-van der Veen; Marcel P M Stokkel; Claudette E Loo; Marie-Jeanne T F D Vrancken Peeters; Renato A Valdés Olmos Journal: J Surg Oncol Date: 2014-09-05 Impact factor: 3.454
Authors: R J Gray; C Salud; K Nguyen; E Dauway; J Friedland; C Berman; E Peltz; G Whitehead; C E Cox Journal: Ann Surg Oncol Date: 2001-10 Impact factor: 5.344
Authors: B Pouw; I M C van der Ploeg; S H Muller; R A Valdés Olmos; L K Janssen-Pinkse; H S A Oldenburg; M T F D Vrancken Peeters Journal: Eur J Surg Oncol Date: 2014-10-27 Impact factor: 4.424
Authors: Bas Pouw; Linda J de Wit-van der Veen; Daan Hellingman; Oscar R Brouwer; Marie-Jeanne Tfd Vrancken Peeters; Marcel Pm Stokkel; Renato A Valdés Olmos Journal: EJNMMI Res Date: 2014-05-03 Impact factor: 3.138