BACKGROUND:Standard wire localization (WL) and excision of nonpalpable breast lesions has several shortcomings. METHODS:Ninety-seven women with nonpalpable breast lesions were prospectively randomized to radioactive seed localization (RSL) or WL. For RSL, a titanium seed containing 125I was placed at the site of the lesion by using radiographical guidance. The surgeon used a handheld gamma detector to locate and excise the seed and lesion. RESULTS: Both techniques resulted in 100% retrieval of the lesions. Fewer RSL patients required resection of additional margins than WL patients (26% vs. 57%, respectively, P = .02). There were no significant differences in mean times for operative excision (5.4 vs. 6.1 minutes) or radiographical localization (13.9 vs. 13.2 minutes). There were also no significant differences in the subjective ease of the procedures as rated by surgeons, radiologists, and patients. All WLs were carried out on the same day as the excision, whereas RSL was performed up to 5 days before the operative procedure. CONCLUSIONS:RSL is as effective as WL for the excision of nonpalpable breast lesions and reduces the incidence of pathologically involved margins of excision. RSL also reduces scheduling conflicts and may allow elimination of intraoperative specimen mammography. RSL is an attractive alternative to WL.
RCT Entities:
BACKGROUND: Standard wire localization (WL) and excision of nonpalpable breast lesions has several shortcomings. METHODS: Ninety-seven women with nonpalpable breast lesions were prospectively randomized to radioactive seed localization (RSL) or WL. For RSL, a titanium seed containing 125I was placed at the site of the lesion by using radiographical guidance. The surgeon used a handheld gamma detector to locate and excise the seed and lesion. RESULTS: Both techniques resulted in 100% retrieval of the lesions. Fewer RSLpatients required resection of additional margins than WLpatients (26% vs. 57%, respectively, P = .02). There were no significant differences in mean times for operative excision (5.4 vs. 6.1 minutes) or radiographical localization (13.9 vs. 13.2 minutes). There were also no significant differences in the subjective ease of the procedures as rated by surgeons, radiologists, and patients. All WLs were carried out on the same day as the excision, whereas RSL was performed up to 5 days before the operative procedure. CONCLUSIONS:RSL is as effective as WL for the excision of nonpalpable breast lesions and reduces the incidence of pathologically involved margins of excision. RSL also reduces scheduling conflicts and may allow elimination of intraoperative specimen mammography. RSL is an attractive alternative to WL.
Authors: P Paredes; S Vidal-Sicart; G Zanón; N Roé; S Rubí; S Lafuente; J Pavía; F Pons Journal: Eur J Nucl Med Mol Imaging Date: 2007-11-28 Impact factor: 9.236
Authors: Hillary W Garner; Joseph M Bestic; Jeffrey J Peterson; Steven Attia; Daniel E Wessell Journal: Skeletal Radiol Date: 2016-11-24 Impact factor: 2.199
Authors: Nidal İflazoğlu; Orhan Üreyen; Murat Kemal Atahan; Ulvi Mehmet Meral; Gülten Sezgin; Ercüment Tarcan Journal: J Breast Health Date: 2015-07-01
Authors: Jennifer M Racz; Amy E Glasgow; Gary L Keeney; Amy C Degnim; Tina J Hieken; James W Jakub; John C Cheville; Elizabeth B Habermann; Judy C Boughey Journal: Ann Surg Oncol Date: 2020-07-04 Impact factor: 5.344
Authors: Erica V Bloomquist; Nicolas Ajkay; Sujata Patil; Abigail E Collett; Thomas G Frazier; Andrea V Barrio Journal: Breast J Date: 2015-12-23 Impact factor: 2.431
Authors: Rick G Pleijhuis; Maurits Graafland; Jakob de Vries; Joost Bart; Johannes S de Jong; Gooitzen M van Dam Journal: Ann Surg Oncol Date: 2009-07-17 Impact factor: 5.344