Literature DB >> 3086483

Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor.

R L Nachman, K A Hajjar, R L Silverstein, C A Dinarello.   

Abstract

Human endothelial cells activated with IL-1 express a surface membrane-oriented procoagulant generating system characterized by increased tissue factor synthesis and decreased thrombomodulin activity. We now report that IL-1 also stimulates endothelial cell synthesis of plasminogen activator inhibitor. This array of IL-1-induced activities shifts the balance at the endothelial cell surface to a prothrombotic influence and may reflect an early response of the blood vessel wall to injury.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3086483      PMCID： PMC2188126          DOI： 10.1084/jem.163.6.1595

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  22 in total

1.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

Review 2.  Human plasma proteinase inhibitors.

Authors:  J Travis; G S Salvesen
Journal:  Annu Rev Biochem       Date:  1983       Impact factor: 23.643

3.  Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells.

Authors:  D J Loskutoff; J A van Mourik; L A Erickson; D Lawrence
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205

4.  The dexamethasone-induced inhibitor of fibrinolytic activity in hepatoma cells. A cellular product which specifically inhibits plasminogen activation.

Authors:  P L Coleman; P A Barouski; T D Gelehrter
Journal:  J Biol Chem       Date:  1982-04-25       Impact factor: 5.157

5.  Purification of human fibroblast urokinase proenzyme and analysis of its regulation by proteases and protease nexin.

Authors:  D L Eaton; R W Scott; J B Baker
Journal:  J Biol Chem       Date:  1984-05-25       Impact factor: 5.157

6.  Thrombin induction of plasminogen activator-inhibitor in cultured human endothelial cells.

Authors:  T D Gelehrter; R Sznycer-Laszuk
Journal:  J Clin Invest       Date:  1986-01       Impact factor: 14.808

7.  Latent tissue plasminogen activator produced by human endothelial cells in culture: evidence for an enzyme-inhibitor complex.

Authors:  E G Levin
Journal:  Proc Natl Acad Sci U S A       Date:  1983-11       Impact factor: 11.205

8.  Serial propagation of human endothelial cells in vitro.

Authors:  T Maciag; G A Hoover; M B Stemerman; R Weinstein
Journal:  J Cell Biol       Date:  1981-11       Impact factor: 10.539

9.  Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells.

Authors:  M P Bevilacqua; J S Pober; G R Majeau; R S Cotran; M A Gimbrone
Journal:  J Exp Med       Date:  1984-08-01       Impact factor: 14.307

10.  Cultured bovine endothelial cells produce both urokinase and tissue-type plasminogen activators.

Authors:  E G Levin; D J Loskutoff
Journal:  J Cell Biol       Date:  1982-09       Impact factor: 10.539
View more
  52 in total

1.  IL-1-induced procoagulant and fibrinolytic activities of human endothelium grown on carbodiimide crosslinked proteins.

Authors:  R Warocquier-Clérout; J Penhoat; M F Sigot-Luizard
Journal:  Cytotechnology       Date:  1991-11       Impact factor: 2.058

2.  Pathophysiologic effect of interleukin-1b in the rabbit retina.

Authors:  J A Martiney; M Litwak; J W Berman; J C Arezzo; C F Brosnan
Journal:  Am J Pathol       Date:  1990-12       Impact factor: 4.307

3.  Regulation of the fibrinolytic system of cultured human vascular endothelium by interleukin 1.

Authors:  M P Bevilacqua; R R Schleef; M A Gimbrone; D J Loskutoff
Journal:  J Clin Invest       Date:  1986-08       Impact factor: 14.808

4.  Inducible release of an endothelial cell-specific protein.

Authors:  C W Carson; G G Hunder; K L Kaplan; C M Johnson
Journal:  Am J Pathol       Date:  1991-07       Impact factor: 4.307

Review 5.  Smoking, the oral contraceptive pill, and Crohn's disease.

Authors:  A J Wakefield; A M Sawyerr; M Hudson; A P Dhillon; R E Pounder
Journal:  Dig Dis Sci       Date:  1991-08       Impact factor: 3.199

6.  Differential regulation of fibrinogen γ chain splice isoforms by interleukin-6.

Authors:  Chantelle M Rein-Smith; Nathan W Anderson; David H Farrell
Journal:  Thromb Res       Date:  2012-10-01       Impact factor: 3.944

7.  Provocation of pulmonary vascular endothelial injury in rabbits by human recombinant interleukin-1 beta.

Authors:  S E Goldblum; K Yoneda; D A Cohen; C J McClain
Journal:  Infect Immun       Date:  1988-09       Impact factor: 3.441

8.  Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition.

Authors:  D J Pinsky; H Liao; C A Lawson; S F Yan; J Chen; P Carmeliet; D J Loskutoff; D M Stern
Journal:  J Clin Invest       Date:  1998-09-01       Impact factor: 14.808

9.  Antidiabetic effects of interleukin 1.

Authors:  A del Rey; H Besedovsky
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

10.  Immunologic effects of national cholesterol education panel step-2 diets with and without fish-derived N-3 fatty acid enrichment.

Authors:  S N Meydani; A H Lichtenstein; S Cornwall; M Meydani; B R Goldin; H Rasmussen; C A Dinarello; E J Schaefer
Journal:  J Clin Invest       Date:  1993-07       Impact factor: 14.808
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.