| Literature DB >> 3085949 |
T M Griffith, D H Edwards, A C Newby, M J Lewis, A H Henderson.
Abstract
The production (synthesis or release or both) of endothelium derived relaxant factor was studied in rabbit aortic strip preparations and an aortic-coronary artery bioassay system. Production of endothelium derived relaxant factor was rapidly inhibited by agents that inhibit mitochondrial electron transport or F1-ATPase, or which uncouple oxidative phosphorylation, but was only slowly impaired by inhibition of glycolysis. It was dependent also on the presence of extracellular calcium with a rapid on-off response time. This study shows that production of endothelium derived relaxant factor appears to be dependent on both oxidative phosphorylation and extracellular calcium.Entities:
Mesh：
Substances：
Year: 1986 PMID： 3085949 DOI： 10.1093/cvr/20.1.7
Source DB: PubMed Journal: Cardiovasc Res ISSN： 0008-6363 Impact factor: 10.787