Camilla Jerlang Christiani1,2, Jens R M Jepsen1,2,3,4, Anne Thorup1,2, Nicoline Hemager1,2,3, Ditte Ellersgaard1,2, Katrine S Spang2,3, Birgitte K Burton2,3, Maja Gregersen1,2, Anne Søndergaard1,2, Aja N Greve2,5, Ditte L Gantriis2,5, Gry Poulsen2,6, Md Jamal Uddin2,6, Larry J Seidman7, Ole Mors2,5, Kerstin J Plessen2,3,8, Merete Nordentoft1,2,9. 1. Mental Health Centre, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark. 2. The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark. 3. Child and Adolescent Mental Health Centre, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark. 4. Center for Neuropsychiatric Schizophrenia Research and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark. 5. Psychosis Research Unit, Aarhus University Hospital, Aarhus, Denmark. 6. Department of Public Health, Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark. 7. Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, Boston, MA. 8. Services of Child and Adolescent Psychiatry, Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland. 9. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Abstract
OBJECTIVE: To characterize social cognition, language, and social behavior as potentially shared vulnerability markers in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP). METHODS: The Danish High-Risk and Resilience Study VIA7 is a multisite population-based cohort of 522 7-year-old children extracted from the Danish registries. The population-based controls were matched to the FHR-SZ children on age, sex, and municipality. The FHR-BP group followed same inclusion criteria. Data were collected blinded to familial high-risk status. Outcomes were social cognition, language, and social behavior. RESULTS: The analysis included 202 FHR-SZ children (girls: 46%), 120 FHR-BP children (girls: 46.7%), and 200 controls (girls: 46.5%). FHR-SZ children displayed significant deficits in language (receptive: d = -0.27, P = .006; pragmatic: d = -0.51, P < .001), social responsiveness (d = -0.54, P < .001), and adaptive social functioning (d = -0.47, P < .001) compared to controls after Bonferroni correction. Compared to FHR-BP children, FHR-SZ children performed significantly poorer on adaptive social functioning (d = -0.29, P = .007) after Bonferroni correction. FHR-BP and FHR-SZ children showed no significant social cognitive impairments compared to controls after Bonferroni correction. CONCLUSION: Language, social responsiveness, and adaptive social functioning deficits seem associated with FHR-SZ but not FHR-BP in this developmental phase. The pattern of results suggests adaptive social functioning impairments may not be shared between FHR-BP and FHR-SZ in this developmental phase and thus not reflective of the shared risk factors for schizophrenia and bipolar disorder.
OBJECTIVE: To characterize social cognition, language, and social behavior as potentially shared vulnerability markers in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP). METHODS: The Danish High-Risk and Resilience Study VIA7 is a multisite population-based cohort of 522 7-year-old children extracted from the Danish registries. The population-based controls were matched to the FHR-SZ children on age, sex, and municipality. The FHR-BP group followed same inclusion criteria. Data were collected blinded to familial high-risk status. Outcomes were social cognition, language, and social behavior. RESULTS: The analysis included 202 FHR-SZ children (girls: 46%), 120 FHR-BP children (girls: 46.7%), and 200 controls (girls: 46.5%). FHR-SZ children displayed significant deficits in language (receptive: d = -0.27, P = .006; pragmatic: d = -0.51, P < .001), social responsiveness (d = -0.54, P < .001), and adaptive social functioning (d = -0.47, P < .001) compared to controls after Bonferroni correction. Compared to FHR-BP children, FHR-SZ children performed significantly poorer on adaptive social functioning (d = -0.29, P = .007) after Bonferroni correction. FHR-BP and FHR-SZ children showed no significant social cognitive impairments compared to controls after Bonferroni correction. CONCLUSION: Language, social responsiveness, and adaptive social functioning deficits seem associated with FHR-SZ but not FHR-BP in this developmental phase. The pattern of results suggests adaptive social functioning impairments may not be shared between FHR-BP and FHR-SZ in this developmental phase and thus not reflective of the shared risk factors for schizophrenia and bipolar disorder.
Authors: Larry J Seidman; Anthony J Giuliano; Christopher W Smith; William S Stone; Stephen J Glatt; Eric Meyer; Stephen V Faraone; Ming T Tsuang; Barbara Cornblatt Journal: Schizophr Bull Date: 2006-05-17 Impact factor: 9.306
Authors: Michael F Green; David L Penn; Richard Bentall; William T Carpenter; Wolfgang Gaebel; Ruben C Gur; Ann M Kring; Sohee Park; Steven M Silverstein; Robert Heinssen Journal: Schizophr Bull Date: 2008-01-08 Impact factor: 9.306
Authors: Lucy Riglin; Stephan Collishaw; Alexander Richards; Ajay K Thapar; Barbara Maughan; Michael C O'Donovan; Anita Thapar Journal: Lancet Psychiatry Date: 2016-12-06 Impact factor: 27.083
Authors: Anne Amalie Elgaard Thorup; Nicoline Hemager; Vibeke Fuglsang Bliksted; Aja Neergaard Greve; Jessica Ohland; Martin Wilms; Sinnika Birkehøj Rohd; Merete Birk; Anette Faurskov Bundgaard; Andreas Færgemand Laursen; Oskar Hougaard Jefsen; Nanna Lawaetz Steffensen; Anna Krogh Andreassen; Lotte Veddum; Christina Bruun Knudsen; Mette Enevoldsen; Marie Nymand; Julie Marie Brandt; Anne Søndergaard; Line Carmichael; Maja Gregersen; Mette Falkenberg Krantz; Birgitte Klee Burton; Martin Dietz; Ron Nudel; Line Korsgaard Johnsen; Kit Melissa Larsen; David Meder; Oliver James Hulme; William Frans Christiaan Baaré; Kathrine Skak Madsen; Torben Ellegaard Lund; Leif Østergaard; Anders Juul; Troels Wesenberg Kjær; Carsten Hjorthøj; Hartwig Roman Siebner; Ole Mors; Merete Nordentoft Journal: Front Psychiatry Date: 2022-04-04 Impact factor: 5.435