Silvia Alonso-Lana1,2, Noemí Moro3,4, Peter J McKenna1,2, Salvador Sarró1,2, Anna Romaguera1,5, Gemma C Monté1,6, Teresa Maristany7, José M Goikolea2,8, Eduard Vieta2,8, Raymond Salvador1,2, Edith Pomarol-Clotet1,2. 1. FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain. 2. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain. 3. Benito Menni Complex Assistencial en Salut Mental, Barcelona, Spain. 4. Department of Psychiatry and Forensic medicine, Universitat Autònoma de Barcelona, Spain. 5. CSMIA Gràcia La Mercè Hermanas Hospitalarias, Barcelona, Spain. 6. Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain. 7. Hospital Sant Joan de Déu Infantil, Barcelona, Spain. 8. Bipolar Disorder Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, Barcelona, Spain.
Abstract
OBJECTIVES: While widespread cortical and subcortical brain functional abnormalities have been found in bipolar disorder, the changes that take place between illness phases and recovery are less clearly documented. Only a small number of longitudinal studies of manic patients, in particular, have been carried out. METHODS: Twenty-six bipolar patients underwent fMRI during performance of the n-back working memory task when manic and again after recovery. Twenty-six matched healthy controls were also scanned on two occasions. Task-related activations and de-activations were examined. RESULTS: When manic, the patients showed clusters of significantly reduced activation in the left dorsolateral prefrontal cortex (DLPFC)/precentral cortex and the parietal cortex/superior precuneus bilaterally. They also showed failure of de-activation in the ventromedial frontal cortex (vmPFC). After recovery, activation in the left DLPFC/precentral cortex and in the bilateral parietal cortex/superior precuneus clusters increased significantly. However, failure of de-activation remained present in the vmPFC. CONCLUSIONS: Recovery from mania is associated with normalization of DLPFC and parietal hypoactivation, but not with vmPFC failure of de-activation, which accordingly appears to represent a trait abnormality in the disorder.
OBJECTIVES: While widespread cortical and subcortical brain functional abnormalities have been found in bipolar disorder, the changes that take place between illness phases and recovery are less clearly documented. Only a small number of longitudinal studies of manicpatients, in particular, have been carried out. METHODS: Twenty-six bipolarpatients underwent fMRI during performance of the n-back working memory task when manic and again after recovery. Twenty-six matched healthy controls were also scanned on two occasions. Task-related activations and de-activations were examined. RESULTS: When manic, the patients showed clusters of significantly reduced activation in the left dorsolateral prefrontal cortex (DLPFC)/precentral cortex and the parietal cortex/superior precuneus bilaterally. They also showed failure of de-activation in the ventromedial frontal cortex (vmPFC). After recovery, activation in the left DLPFC/precentral cortex and in the bilateral parietal cortex/superior precuneus clusters increased significantly. However, failure of de-activation remained present in the vmPFC. CONCLUSIONS: Recovery from mania is associated with normalization of DLPFC and parietal hypoactivation, but not with vmPFC failure of de-activation, which accordingly appears to represent a trait abnormality in the disorder.
Authors: Jay C Fournier; Michele Bertocci; Cecile D Ladouceur; Lisa Bonar; Kelly Monk; Halimah Abdul-Waalee; Amelia Versace; João Paulo Lima Santos; Satish Iyengar; Boris Birmaher; Mary L Phillips Journal: Neuropsychopharmacology Date: 2021-03-29 Impact factor: 8.294
Authors: Amy S Garrett; Kiki D Chang; Manpreet K Singh; Casey C Armstrong; Patricia D Walshaw; David J Miklowitz Journal: Bipolar Disord Date: 2021-01-26 Impact factor: 5.345
Authors: Michele A Bertocci; Jeffrey Bergman; Joao Paulo Lima Santos; Satish Iyengar; Lisa Bonar; Mary Kay Gill; Halimah Abdul-Waalee; Genna Bebko; Richelle Stiffler; Jeanette Lockovich; Haris Aslam; Cecile Ladouceur; John Merranko; Rasim Diler; Boris Birmaher; Amelia Versace; Mary L Phillips Journal: Transl Psychiatry Date: 2020-11-02 Impact factor: 6.222