| Literature DB >> 30848447 |
Takashi Owaki1,2, Hiroki Sato3,4, Ryoko Horigome1, Satoru Hashimoto2, Terasu Honma1, Shuji Terai2.
Abstract
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disorder in the esophagus characterized by symptoms related to esophageal dysfunction and eosinophil-predominant inflammation. EoE and Gastro Esophageal Reflux Disease (GERD) are known not to be mutually exclusive and share a complex relationship. Proton pump inhibitors (PPIs), which are generally used in the treatment of GERD, could be used to treat esophageal eosinophilia in suspected EoE. We report a rare case of EoE after total gastrectomy that responded to PPIs. Our case indicates that the onset of EoE does not necessarily require an acid reflux-induced antigen-mediated drive, and the action of PPIs in patients with active EoE is unrelated to gastric acid suppression.Entities:
Keywords: Eosinophilic esophagitis; Gastrectomy; Gastro esophageal reflux disease; PPI-responsive esophageal eosinophilia; Proton pump inhibitor
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Year: 2019 PMID： 30848447 DOI： 10.1007/s12328-019-00960-4
Source DB: PubMed Journal: Clin J Gastroenterol ISSN： 1865-7265