| Literature DB >> 24813513 |
Edaire Cheng1, Rhonda F Souza2, Stuart Jon Spechler2.
Abstract
Gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) are not mutually exclusive. The notion that GERD and EoE can be distinguished by the response to proton pump inhibitor (PPI) treatment is based on the mistaken assumption that gastric acid suppression is the only important therapeutic effect of PPIs, and therefore only GERD can respond to PPIs. We believe that a clinical or histologic response to PPIs does not rule in GERD or rule out EoE. We recommend a trial of PPI therapy for patients with symptomatic esophageal eosinophilia, even if the diagnosis of EoE seems clear-cut.Entities:
Keywords: Eosinophilic esophagitis; Gastroesophageal reflux disease; PPI-responsive esophageal eosinophilia; Proton pump inhibitors
Mesh:
Substances:
Year: 2014 PMID: 24813513 PMCID: PMC4019936 DOI: 10.1016/j.gtc.2014.02.004
Source DB: PubMed Journal: Gastroenterol Clin North Am ISSN: 0889-8553 Impact factor: 3.806