Jonathan González-García1, Fernando Gutiérrez-Nicolás2, Gloria Julia Nazco-Casariego3, María Micaela Viña-Romero4. 1. Servicio de Farmacia, Complejo Hospitalario Universitario de Canarias, San Cristóbal de La Laguna, Tenerife.. jonathangnz@gmail.com. 2. Servicio de Farmacia, Complejo Hospitalario Universitario de Canarias, San Cristóbal de La Laguna, Tenerife.. fgunico@gmail.com. 3. Servicio de Farmacia, Complejo Hospitalario Universitario de Canarias, San Cristóbal de La Laguna, Tenerife.. jnazcas@gobiernodecanarias.org. 4. Servicio de Farmacia, Hospital Universitario Nuestra Señora de La Candelaria, Santa Cruz de Tenerife, Tenerife.. kellyviro@gmail.com.
Abstract
OBJECTIVE: The present work analyzed the stability of trastuzumab concentrations in blood and plasma samples stored at 4 °C and -20 °C. METHOD: Blood samples of patients treated with trastuzumab (Herceptin ®) were analyzed. Stability of trastuzumab was analyzed under different conditions: whole blood stored at 4 °C during 72 hours, blood plasma stored at 4 °C during 120 hours and blood plasma stored at -20 °C during 365 days. RESULTS: In whole blood trastuzumab concentration at 72 hours was 99.01 ± 0.02%, and in plasma samples at 120 hours it was 98.6 ± 2.0%. The concentration of trastuzumab was 95.22 ± 3.20% after 12 months' storage at -20 ºC. CONCLUSIONS: The concentration of trastuzumab remains stable for at least 72 hours in whole blood stored at 4 °C, five days in plasma stored at 4 °C and one year in plasma stored at -20 °C. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
OBJECTIVE: The present work analyzed the stability of trastuzumab concentrations in blood and plasma samples stored at 4 °C and -20 °C. METHOD: Blood samples of patients treated with trastuzumab (Herceptin ®) were analyzed. Stability of trastuzumab was analyzed under different conditions: whole blood stored at 4 °C during 72 hours, blood plasma stored at 4 °C during 120 hours and blood plasma stored at -20 °C during 365 days. RESULTS: In whole blood trastuzumab concentration at 72 hours was 99.01 ± 0.02%, and in plasma samples at 120 hours it was 98.6 ± 2.0%. The concentration of trastuzumab was 95.22 ± 3.20% after 12 months' storage at -20 ºC. CONCLUSIONS: The concentration of trastuzumab remains stable for at least 72 hours in whole blood stored at 4 °C, five days in plasma stored at 4 °C and one year in plasma stored at -20 °C. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.