Laura Perna1, H W Wahl2,3, J Weberpals4, L Jansen4, U Mons4,5, B Schöttker4,3, H Brenner4,3. 1. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581/TP4, 69120, Heidelberg, Germany. l.perna@dkfz-heidelberg.de. 2. Department of Psychological Aging Research, Institute of Psychology, Heidelberg University, Hauptstrasse 47-51, 69117, Heidelberg, Germany. 3. Network Aging Research (NAR), Heidelberg University, Bergheimer Straße 20, 69115, Heidelberg, Germany. 4. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581/TP4, 69120, Heidelberg, Germany. 5. Cancer Prevention Unit, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Abstract
PURPOSE: The aim of this study was to investigate the independent and combined association of incident depression and dementia with mortality and to explore whether the magnitude of the association varies according to different types of dementia, including Alzheimer's disease and vascular dementia. METHODS AND DESIGN: The study was based on a population-based longitudinal cohort consisting of 9940 participants at baseline and followed for over 14 years. The sample used for the analyses included 6114 participants with available information on diagnosis of incident dementia and depression. For survival analyses, Cox regression models with incident dementia (n = 293; 5%) and incident depression (n = 746; 12%) as time-dependent variables were used. RESULTS: Cox models adjusted for relevant confounders indicated that comorbidity of incident vascular dementia and incident depression was associated with a much higher mortality risk (HR 6.99; 95% CI 3.84-12.75) than vascular dementia in the absence of depression (HR 2.80; 95% CI 1.92-4.08). In contrast, estimates for comorbidity of Alzheimer's disease and depression were slightly lower than those for Alzheimer in absence of depression (HR 3.56; 95% CI 1.83-6.92 and HR 4.19; 95% CI 2.97-5.90, respectively). Incident depression in the absence of incident dementia was only weakly associated with mortality. CONCLUSIONS: These findings indicate that depression and vascular dementia might have synergistic effects on mortality. The results have relevant public health implications for prevention, routine screening for and early treatment of depression among older people, especially those at risk of vascular dementia.
PURPOSE: The aim of this study was to investigate the independent and combined association of incident depression and dementia with mortality and to explore whether the magnitude of the association varies according to different types of dementia, including Alzheimer's disease and vascular dementia. METHODS AND DESIGN: The study was based on a population-based longitudinal cohort consisting of 9940 participants at baseline and followed for over 14 years. The sample used for the analyses included 6114 participants with available information on diagnosis of incident dementia and depression. For survival analyses, Cox regression models with incident dementia (n = 293; 5%) and incident depression (n = 746; 12%) as time-dependent variables were used. RESULTS:Cox models adjusted for relevant confounders indicated that comorbidity of incident vascular dementia and incident depression was associated with a much higher mortality risk (HR 6.99; 95% CI 3.84-12.75) than vascular dementia in the absence of depression (HR 2.80; 95% CI 1.92-4.08). In contrast, estimates for comorbidity of Alzheimer's disease and depression were slightly lower than those for Alzheimer in absence of depression (HR 3.56; 95% CI 1.83-6.92 and HR 4.19; 95% CI 2.97-5.90, respectively). Incident depression in the absence of incident dementia was only weakly associated with mortality. CONCLUSIONS: These findings indicate that depression and vascular dementia might have synergistic effects on mortality. The results have relevant public health implications for prevention, routine screening for and early treatment of depression among older people, especially those at risk of vascular dementia.
Authors: J H Park; S B Lee; T J Lee; D Y Lee; J H Jhoo; J C Youn; I H Choo; E A Choi; J W Jeong; J Y Choe; J I Woo; K W Kim Journal: Dement Geriatr Cogn Disord Date: 2006-11-15 Impact factor: 2.959
Authors: Stephen R Cole; Robert W Platt; Enrique F Schisterman; Haitao Chu; Daniel Westreich; David Richardson; Charles Poole Journal: Int J Epidemiol Date: 2009-11-19 Impact factor: 7.196
Authors: Carl Salzman; Dilip V Jeste; Roger E Meyer; Jiska Cohen-Mansfield; Jeffrey Cummings; George T Grossberg; Lissy Jarvik; Helena C Kraemer; Barry D Lebowitz; Katie Maslow; Bruce G Pollock; Murray Raskind; Susan K Schultz; Philip Wang; Julie M Zito; George S Zubenko Journal: J Clin Psychiatry Date: 2008-06 Impact factor: 4.384
Authors: Thi Ngoc Mai Nguyen; Li-Ju Chen; Kira Trares; Hannah Stocker; Bernd Holleczek; Konrad Beyreuther; Hermann Brenner; Ben Schöttker Journal: Alzheimers Res Ther Date: 2022-05-28 Impact factor: 8.823
Authors: H Stocker; L Perna; K Weigl; T Möllers; B Schöttker; H Thomsen; B Holleczek; D Rujescu; H Brenner Journal: Mol Psychiatry Date: 2020-05-13 Impact factor: 15.992