BACKGROUND/AIMS: To compare the prevalence and characteristics of depression in vascular dementia (VaD) and Alzheimer's disease (AD) after adjusting for dementia severity and gender. METHODS: One hundred and eight pairs of VaD and AD patients matched for dementia severity and gender were assessed. RESULTS: Major depressive disorder (MDD) was more prevalent in the VaD group than in the AD group (20.4% in VaD, 10.2% in AD, p = 0.04, Cochran-Mantel-Haenszel, CMH, test) regardless of the dementia severity and gender. The odds ratio for developing MDD in the VaD group versus the AD group was estimated to be 2.20 (95% confidence interval = 1.02-4.74). Neurovegetative symptoms such as 'felt tired and weak all the time' (30.6% in VaD, 13.9% in AD, p = 0.003, CMH test) and 'changed weight without trying' (16.7% in VaD, 6.5% in AD, p = 0.02, CMH test) were more prevalent in the VaD group than in the AD group. CONCLUSION: Depression in VaD was quantitatively and qualitatively different from that in AD regardless of the severity of dementia and gender; depression was more prevalent, severer and more retarded and vegetative in VaD than in AD. Copyright (c) 2007 S. Karger AG, Basel.
BACKGROUND/AIMS: To compare the prevalence and characteristics of depression in vascular dementia (VaD) and Alzheimer's disease (AD) after adjusting for dementia severity and gender. METHODS: One hundred and eight pairs of VaD and ADpatients matched for dementia severity and gender were assessed. RESULTS: Major depressive disorder (MDD) was more prevalent in the VaD group than in the AD group (20.4% in VaD, 10.2% in AD, p = 0.04, Cochran-Mantel-Haenszel, CMH, test) regardless of the dementia severity and gender. The odds ratio for developing MDD in the VaD group versus the AD group was estimated to be 2.20 (95% confidence interval = 1.02-4.74). Neurovegetative symptoms such as 'felt tired and weak all the time' (30.6% in VaD, 13.9% in AD, p = 0.003, CMH test) and 'changed weight without trying' (16.7% in VaD, 6.5% in AD, p = 0.02, CMH test) were more prevalent in the VaD group than in the AD group. CONCLUSION:Depression in VaD was quantitatively and qualitatively different from that in AD regardless of the severity of dementia and gender; depression was more prevalent, severer and more retarded and vegetative in VaD than in AD. Copyright (c) 2007 S. Karger AG, Basel.
Authors: David C Steffens; Gwenith G Fisher; Kenneth M Langa; Guy G Potter; Brenda L Plassman Journal: Int Psychogeriatr Date: 2009-06-12 Impact factor: 3.878
Authors: Ahsan Habib; R Douglas Shytle; Darrell Sawmiller; Selina Koilraj; Sadia Afrin Munna; David Rongo; Huayan Hou; Cesario V Borlongan; Glenn Currier; Jun Tan Journal: J Neurosci Res Date: 2019-05-17 Impact factor: 4.164
Authors: Laura Perna; H W Wahl; J Weberpals; L Jansen; U Mons; B Schöttker; H Brenner Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2019-03-06 Impact factor: 4.328
Authors: Deborah E Barnes; Kristine Yaffe; Amy L Byers; Mark McCormick; Catherine Schaefer; Rachel A Whitmer Journal: Arch Gen Psychiatry Date: 2012-05
Authors: Meryl A Butters; Jeffrey B Young; Oscar Lopez; Howard J Aizenstein; Benoit H Mulsant; Charles F Reynolds; Steven T DeKosky; James T Becker Journal: Dialogues Clin Neurosci Date: 2008 Impact factor: 5.986