Literature DB >> 30838636

Why is pancreatic cancer so deadly? The pathologist's view.

Ralph H Hruban1, Matthias M Gaida2, Elizabeth Thompson1, Seung-Mo Hong1,3, Michaël Noë1, Lodewijk Aa Brosens4,5, Martine Jongepier4, G Johan A Offerhaus4, Laura D Wood1.   

Abstract

The remarkable aggressiveness of pancreatic cancer has never been fully explained. Although clearly multifactorial, we postulate that venous invasion, a finding seen in most pancreatic cancers but not in most cancers of other organs, may be a significant, underappreciated contributor to the aggressiveness of this disease.
Copyright © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Entities:  

Keywords:  pancreas; pancreas cancer; pancreatic cancer; prognosis; tumor immune microenvironment; vein; venous invasion

Mesh：

Year:  2019        PMID： 30838636     DOI： 10.1002/path.5260

Source DB:  PubMed          Journal:  J Pathol        ISSN： 0022-3417            Impact factor:   7.996


  28 in total

1.  Accurate Nodal Staging in Pancreatic Cancer in the Era of Neoadjuvant Therapy.

Authors:  Ammar A Javed; Ding Ding; Erum Baig; Michael J Wright; Jonathan A Teinor; Daniyal Mansoor; Elizabeth Thompson; Ralph H Hruban; Amol Narang; William R Burns; Richard A Burkhart; Kelly Lafaro; Matthew J Weiss; John L Cameron; Christopher L Wolfgang; Jin He
Journal:  World J Surg       Date:  2022-01-07       Impact factor: 3.352

2.  Intact SMAD-4 is a predictor of increased locoregional recurrence in upfront resected pancreas cancer receiving adjuvant therapy.

Authors:  Hunter C Gits; Amy H Tang; William S Harmsen; William R Bamlet; Rondell P Graham; Gloria M Petersen; Thomas C Smyrk; Amit Mahipal; Roman O Kowalchuk; Jonathan B Ashman; William G Rule; Dawn Owen; Michelle A Neben Wittich; Robert R McWilliams; Thorvardur Halfdanarson; Wen Wee Ma; Terence T Sio; Sean P Cleary; Mark J Truty; Michael G Haddock; Christopher L Hallemeier; Kenneth W Merrell
Journal:  J Gastrointest Oncol       Date:  2021-10

3.  Proteogenomic characterization of pancreatic ductal adenocarcinoma.

Authors:  Liwei Cao; Chen Huang; Daniel Cui Zhou; Yingwei Hu; T Mamie Lih; Sara R Savage; Karsten Krug; David J Clark; Michael Schnaubelt; Lijun Chen; Felipe da Veiga Leprevost; Rodrigo Vargas Eguez; Weiming Yang; Jianbo Pan; Bo Wen; Yongchao Dou; Wen Jiang; Yuxing Liao; Zhiao Shi; Nadezhda V Terekhanova; Song Cao; Rita Jui-Hsien Lu; Yize Li; Ruiyang Liu; Houxiang Zhu; Peter Ronning; Yige Wu; Matthew A Wyczalkowski; Hariharan Easwaran; Ludmila Danilova; Arvind Singh Mer; Seungyeul Yoo; Joshua M Wang; Wenke Liu; Benjamin Haibe-Kains; Mathangi Thiagarajan; Scott D Jewell; Galen Hostetter; Chelsea J Newton; Qing Kay Li; Michael H Roehrl; David Fenyö; Pei Wang; Alexey I Nesvizhskii; D R Mani; Gilbert S Omenn; Emily S Boja; Mehdi Mesri; Ana I Robles; Henry Rodriguez; Oliver F Bathe; Daniel W Chan; Ralph H Hruban; Li Ding; Bing Zhang; Hui Zhang
Journal:  Cell       Date:  2021-09-16       Impact factor: 66.850

4.  The Impact of the COVID-19 Pandemic on Multidisciplinary Clinics: A High-Volume Pancreatic Cancer Center Experience.

Authors:  Ammar A Javed; Joseph R Habib; Benedict Kinny-Köster; Mary Hodgin; Lindsay Parish; Dea Cunningham; Amy Hacker-Prietz; Richard A Burkhart; William R Burns; Christopher R Shubert; John L Cameron; Atif Zaheer; Linda C H Chu; Satomi Kawamoto; Elizabeth D Thompson; Eun J Shin; Amol Narang; Lei Zheng; Daniel A Laheru; Ralph H Hruban; Jin He; Christopher L Wolfgang; Elliot K Fishman; Kelly Lafaro
Journal:  Curr Probl Diagn Radiol       Date:  2022-05-25

Review 5.  Circulating tumor cells as Trojan Horse for understanding, preventing, and treating cancer: a critical appraisal.

Authors:  Alexios-Fotios A Mentis; Petros D Grivas; Efthimios Dardiotis; Nicholas A Romas; Athanasios G Papavassiliou
Journal:  Cell Mol Life Sci       Date:  2020-04-24       Impact factor: 9.261

6.  Ovarian Metastasis from Pancreatic Ductal Adenocarcinoma.

Authors:  Elliot K Fishman; Ammar A Javed; Joseph R Habib; Shamsher Pasha; Subhan Khan; Benedict Kinny-Köster; Sami Shoucair; Elizabeth D Thompson; Jun Yu; Kelly Lafaro; Richard A Burkhart; William R Burns; Brigitte M Ronnett; Christopher L Wolfgang; Ralph H Hruban; Jin He
Journal:  World J Surg       Date:  2021-07-08       Impact factor: 3.352

7.  Desmoplastic Crosstalk in Pancreatic Ductal Adenocarcinoma Is Reflected by Different Responses of Panc-1, MIAPaCa-2, PaTu-8902, and CAPAN-2 Cell Lines to Cancer-associated/Normal Fibroblasts.

Authors:  Štepán Novák; Michal Kolář; Arpád Szabó; Zdena Vernerová; Lukáš Lacina; Hynek Strnad; Jana Šáchová; Miluše Hradilová; Jan Havránek; Michal Španko; Matúš Čoma; Lukáš Urban; Miriam Kaňuchová; Nikola Melegová; Robert Gürlich; Josef Dvořák; Karel Smetana; Peter Gál; Pavol Szabo
Journal:  Cancer Genomics Proteomics       Date:  2021 May-Jun       Impact factor: 4.069

Review 8.  The genetics of ductal adenocarcinoma of the pancreas in the year 2020: dramatic progress, but far to go.

Authors:  Elizabeth D Thompson; Nicholas J Roberts; Laura D Wood; James R Eshleman; Michael G Goggins; Scott E Kern; Alison P Klein; Ralph H Hruban
Journal:  Mod Pathol       Date:  2020-07-23       Impact factor: 7.842

9.  Prognostic Significance of Microvascular Invasion in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis.

Authors:  Huangbao Li; Weiwei Pan; Liu Xu; Dong Yin; Shuqun Cheng; Fengqing Zhao
Journal:  Med Sci Monit       Date:  2021-08-16

10.  Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium.

Authors:  Michael Goggins; Kasper Alexander Overbeek; Randall Brand; Sapna Syngal; Marco Del Chiaro; Detlef K Bartsch; Claudio Bassi; Alfredo Carrato; James Farrell; Elliot K Fishman; Paul Fockens; Thomas M Gress; Jeanin E van Hooft; R H Hruban; Fay Kastrinos; Allison Klein; Anne Marie Lennon; Aimee Lucas; Walter Park; Anil Rustgi; Diane Simeone; Elena Stoffel; Hans F A Vasen; Djuna L Cahen; Marcia Irene Canto; Marco Bruno
Journal:  Gut       Date:  2019-10-31       Impact factor: 23.059
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