Literature DB >> 3083813

Affinity isolation of the interleukin-3 surface receptor.

W S May, J N Ihle.   

Abstract

Interleukin-3 (IL-3) is a pluripotent hematopoietic growth factor which can stimulate both proliferation and differentiation of progenitor cells. Using the factor dependent NSF-60 and FDC-P1 cells, which possess specific, high affinity binding sites for 125I-IL-3 (i.e. KD 9.5 and 10.7 X 10(-11)M, respectively) the IL-3 surface receptor has been isolated. Using two separate affinity techniques the IL-3 receptor identified from both cell types was invariant. The IL-3 receptor is a protein of molecular weight 65-70,000 daltons.

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Year:  1986        PMID： 3083813     DOI： 10.1016/0006-291x(86)91009-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  Interleukin 3 binds to a 140-kDa phosphotyrosine-containing cell surface protein.

Authors:  R J Isfort; D Stevens; W S May; J N Ihle
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

2.  Insertion and truncation of c-myb by murine leukemia virus in a myeloid cell line derived from cultures of normal hematopoietic cells.

Authors:  Y Weinstein; J L Cleveland; D S Askew; U R Rapp; J N Ihle
Journal:  J Virol       Date:  1987-07       Impact factor: 5.103

3.  The v-fms oncogene induces factor-independent growth and transformation of the interleukin-3-dependent myeloid cell line FDC-P1.

Authors:  E F Wheeler; D Askew; S May; J N Ihle; C J Sherr
Journal:  Mol Cell Biol       Date:  1987-05       Impact factor: 4.272

4.  v-rasH induces non-small cell phenotype, with associated growth factors and receptors, in a small cell lung cancer cell line.

Authors:  J P Falco; S B Baylin; R Lupu; M Borges; B D Nelkin; R K Jasti; N E Davidson; M Mabry
Journal:  J Clin Invest       Date:  1990-06       Impact factor: 14.808

5.  Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

Authors:  K Hayashida; T Kitamura; D M Gorman; K Arai; T Yokota; A Miyajima
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

6.  Hematopoietic growth factor receptors.

Authors:  J H Shieh; M A Moore
Journal:  Cytotechnology       Date:  1989-12       Impact factor: 2.058

7.  Two distinct functional high affinity receptors for mouse interleukin-3 (IL-3).

Authors:  T Hara; A Miyajima
Journal:  EMBO J       Date:  1992-05       Impact factor: 11.598

8.  Interleukin 3-specific tyrosine phosphorylation of a membrane glycoprotein of Mr 150,000 in multi-factor-dependent myeloid cell lines.

Authors:  S Koyasu; A Tojo; A Miyajima; T Akiyama; M Kasuga; A Urabe; J Schreurs; K Arai; F Takaku; I Yahara
Journal:  EMBO J       Date:  1987-12-20       Impact factor: 11.598
  8 in total

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