Literature DB >> 2460860

Interleukin 3 binds to a 140-kDa phosphotyrosine-containing cell surface protein.

R J Isfort1, D Stevens, W S May, J N Ihle.   

Abstract

Interleukin 3 (IL-3) is a hematopoietic growth factor that supports the proliferation and differentiation of early hematopoietic-lineage progenitors. By using growth factor-dependent cell lines, IL-3 has been shown to induce the appearance of several phosphotyrosine-containing proteins, including a 140-kDa cell surface phosphoprotein. Here we demonstrate that the 140-kDa phosphoprotein binds IL-3 and forms a stable complex with an apparent molecular mass of 170 kDa. The possible relationship of the 140-kDa phosphoprotein to the previously described 65-kDa IL-3-binding protein is discussed.

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Year:  1988        PMID： 2460860      PMCID： PMC282337          DOI： 10.1073/pnas.85.21.7982

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

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4.  Evidence for specific receptors for interleukin 3 on lymphokine-dependent cell lines established from long-term bone marrow cultures.

Authors:  E W Palaszynski; J N Ihle
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Authors:  W L Farrar; T P Thomas; W B Anderson
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  16 in total

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