Literature DB >> 30835923

pH-Responsive Polymer Nanoparticles for Drug Delivery.

Nayeleh Deirram1, Changhe Zhang1, Sarah S Kermaniyan1, Angus P R Johnston2, Georgina K Such1.   

Abstract

Stimuli-responsive nanoparticles have the potential to improve the delivery of therapeutics to a specific cell or region within the body. There are many stimuli that have shown potential for specific release of cargo, including variation of pH, redox potential, or the presence of enzymes. pH variation has generated significant interest for the synthesis of stimuli-responsive nanoparticles because nanoparticles are internalized into cells via vesicles that are acidified. Additionally, the tumor microenvironment is known to have a lower pH than the surrounding tissue. In this review, different strategies to design pH-responsive nanoparticles are discussed, focusing on the use of charge-shifting polymers, acid labile linkages, and crosslinking.
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  charge shifting; drug delivery; pH-cleavable; pH-responsive nanoparticles; stimuli-responsive

Mesh：

Substances：

Year:  2019        PMID： 30835923     DOI： 10.1002/marc.201800917

Source DB:  PubMed          Journal:  Macromol Rapid Commun        ISSN： 1022-1336            Impact factor:   5.734


  41 in total

Review 1.  Targeting neuroinflammation by intranasal delivery of nanoparticles in neurological diseases: a comprehensive review.

Authors:  Fatemeh Moradi; Nasrin Dashti
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2022-01-04       Impact factor: 3.000

Review 2.  Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: a comprehensive review on targeting and recent advances.

Authors:  Khaled Mahmoud; Shady Swidan; Mohamed El-Nabarawi; Mahmoud Teaima
Journal:  J Nanobiotechnology       Date:  2022-03-05       Impact factor: 10.435

Review 3.  Polymeric Coatings and Antimicrobial Peptides as Efficient Systems for Treating Implantable Medical Devices Associated-Infections.

Authors:  Irina Negut; Bogdan Bita; Andreea Groza
Journal:  Polymers (Basel)       Date:  2022-04-15       Impact factor: 4.967

4.  pH- and Ultrasound-Responsive Paclitaxel-Loaded Carboxymethyl Chitosan Nanodroplets for Combined Imaging and Synergistic Chemoradiotherapy.

Authors:  Mengmeng Shang; Xiao Sun; Lu Guo; Dandan Shi; Ping Liang; Dong Meng; Xiaoying Zhou; Xinxin Liu; Yading Zhao; Jie Li
Journal:  Int J Nanomedicine       Date:  2020-01-24

Review 5.  Emerging Approaches to Functionalizing Cell Membrane-Coated Nanoparticles.

Authors:  Xiangzhao Ai; Shuyan Wang; Yaou Duan; Qiangzhe Zhang; Maggie S Chen; Weiwei Gao; Liangfang Zhang
Journal:  Biochemistry       Date:  2020-06-02       Impact factor: 3.162

6.  Mechano-Nanoswitches for Ultrasound-Controlled Drug Activation.

Authors:  Shuaidong Huo; Zhihuan Liao; Pengkun Zhao; Yu Zhou; Robert Göstl; Andreas Herrmann
Journal:  Adv Sci (Weinh)       Date:  2022-02-23       Impact factor: 17.521

7.  Combinatorial Library of Cyclic Benzylidene Acetal-Containing pH-Responsive Lipidoid Nanoparticles for Intracellular mRNA Delivery.

Authors:  Yamin Li; Raissa Li; Anirban Chakraborty; Roza Ogurlu; Xuewei Zhao; Jinjin Chen; Qiaobing Xu
Journal:  Bioconjug Chem       Date:  2020-06-24       Impact factor: 6.069

8.  Photosensitive Supramolecular Micelle-Mediated Cellular Uptake of Anticancer Drugs Enhances the Efficiency of Chemotherapy.

Authors:  Yihalem Abebe Alemayehu; Wen-Lu Fan; Fasih Bintang Ilhami; Chih-Wei Chiu; Duu-Jong Lee; Chih-Chia Cheng
Journal:  Int J Mol Sci       Date:  2020-06-30       Impact factor: 5.923

9.  TMTP1-Modified, Tumor Microenvironment Responsive Nanoparticles Co-Deliver Cisplatin and Paclitaxel Prodrugs for Effective Cervical Cancer Therapy.

Authors:  Guiying Jiang; Xueqian Wang; Ying Zhou; Chenming Zou; Ling Wang; Wei Wang; Danya Zhang; Hanjie Xu; Jie Li; Fei Li; Danfeng Luo; Xiangyi Ma; Ding Ma; Songwei Tan; Rui Wei; Ling Xi
Journal:  Int J Nanomedicine       Date:  2021-06-15

10.  Poly Lactic-Co-Glycolic Acid- (PLGA-) Loaded Nanoformulation of Cisplatin as a Therapeutic Approach for Breast Cancers.

Authors:  Saad Alkahtani; Saud Alarifi; Gadah Albasher; Mohammed Al-Zharani; Nada H Aljarba; Mohammed H Almarzoug; Norah M Alhoshani; Norah S Al-Johani; Hani Alothaid; Abdullah A Alkahtane
Journal:  Oxid Med Cell Longev       Date:  2021-06-28       Impact factor: 6.543
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